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Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite

  • W. L. Hall (a1), D. J. Millward (a1), S. J. Long (a1) and L. M. Morgan (a1)
Abstract

Protein, generally agreed to be the most satiating macronutrient, may differ in its effects on appetite depending on the protein source and variation in digestion and absorption. We investigated the effects of two milk protein types, casein and whey, on food intake and subjective ratings of hunger and fullness, and on postprandial metabolite and gastrointestinal hormone responses. Two studies were undertaken. The first study showed that energy intake from a buffet meal ad libitum was significantly less 90 min after a 1700 kJ liquid preload containing 48 g whey, compared with an equivalent casein preload (P<0·05). In the second study, the same whey preload led to a 28 % increase in postprandial plasma amino acid concentrations over 3 h compared with casein (incremental area under the curve (iAUC), P<0·05). Plasma cholecystokinin (CCK) was increased by 60 % (iAUC, P<0·005), glucagon-like peptide (GLP)-1 by 65 % (iAUC, P<0·05) and glucose-dependent insulinotropic polypeptide by 36 % (iAUC, P<0·01) following the whey preload compared with the casein. Gastric emptying was influenced by protein type as evidenced by differing plasma paracetamol profiles with the two preloads. Greater subjective satiety followed the whey test meal (P<0·05). These results implicate post-absorptive increases in plasma amino acids together with both CCK and GLP-1 as potential mediators of the increased satiety response to whey and emphasise the importance of considering the impact of protein type on the appetite response to a mixed meal.

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Corresponding author
*Corresponding author: Dr W. L. Hall, fax +44 1483 576978, email w.hall@surrey.ac.uk
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AB Ballinger & ML Clark (1994) L-Phenylalanine releases chole-cystokinin (CCK) and is associated with reduced food intake in humans: evidence for a physiological role of CCK in control of eating. Metabolism 43, 735738.

K Beardshall , P Deprez , RJ Playford , M Alexander & J Calam (1992) Effect of chymotrypsin on human cholecystokinin release – use of clostripan in the validation of a new radio-immunoassay. Regulatory Peptides 40, 112.

Y Boirie , M Dangin , P Gachon , M Vasson , J Maubois & B Beaufrere (1997) Slow and fast dietary proteins differently modulate postprandial protein accretion. Proceedings of the National Academy of Sciences of the United States of America 94, 1493014935.

DA Booth , A Chase & AT Campbell (1970) Relative effectiveness of protein in the late stages of appetite suppression in man. Physiology and Behavior 5, 12991302.

JM De Castro (1987) Macronutrient relationships with meal patterns and mood in the spontaneous feeding behaviour of humans. Physiology and Behavior 39, 561569.

RM Elliott , LM Morgan , JA Tredger , S Deacon , J Wright & V Marks (1993) GLP-1 (7–36) amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24 h secretion patterns. Journal of Endocrinology 138, 159166.

A Flint , A Raben , JE Blundell & A Astrup (2000) Reproducibility, power and validity of visual analogue scales in assessment of appetite. International Journal of Obesity 24, 3848.

MC Gannon , FQ Nuttal , BJ Neil & SA Westphal (1988) The insulin and glucose responses to meals of glucose plus various proteins in type II diabetic subjects. Metabolism 37, 10811088.

VLW Go , AF Hofman & WHJ Summerskill (1970) Pancreozymin bioassay in man based on pancreatic enzyme secretion: potency of specific amino acids and other digestive products. Journal of Clinical Investigation 49, 15581564.

JP Gutzwiller , B Goke , J Drewe , P Hildebrand , S Ketterer , D Handschin , R Winterhalder , D Conen & C Beglinger (1999) Glucagon-like peptide-1: a potent regulator of food intake in humans. Gut 44, 8186.

RC Heading , J Nimmo , LF Prescott & P Tothill (1973) The dependence of paracetamol absorption on the rate of gastric emptying. British Journal of Pharmacology 47, 415421.

N Hrboticky , LA Leiter & GH Anderson (1985) Effects of L-tryptophan on short-term food-intake in lean men. Nutrition Research 5, 595607.

R Hubbard , CL Kosch , A Sanchez , J Sabate , L Berk & G Shavlik (1989) Effect of dietary protein on serum insulin and glucagon levels in hyper-and normocholesterolemic men. Atherosclerosis 76, 5561.

V Lang , F Bellisle , C Alamowitch , C Craplet , FRJ Bornet , G Slama & B Guy-Grand (1999) Varying the protein source in mixed meal modifies glucose, insulin and glucagon kinetics in healthy men, has weak effects on subjective satiety and fails to affect food intake. European Journal of Clinical Nutrition 53, 959965.

JD Latner & M Schwartz (1999) The effects of a high-carbohydrate, high-protein or balanced lunch upon later food intake and hunger ratings. Appetite 33, 119128.

RJ Lieverse , JBMJ Jansen , AAM Masclee & CBHW Lamers (1994) Satiety effects of cholecystokinin in humans. Gastro-enterology 106, 14511454.

SJ Long , AR Jeffcoat & DJ Millward (2000) Effect of habitual dietary-protein intake on appetite and satiety. Appetite 35, 7988.

M Porrini , A Santangelo , R Crovetti , P Riso , G Testolin & JE Blundell (1997) Weight, protein, fat and timing of preloads affect food intake. Physiology and Behavior 62, 563570.

PJ Rogers , VJ Burley , LA Alikhanizadeh & JE Blundell (1995) Postingestive inhibition of food intake by aspartame: importance of interval between aspartame administration and subsequent eating. Physiology and Behavior 57, 489493.

J Schirra , M Katschinski , C Weldmann , T Schafer , U Wank , R Arnold & B Goke (1996) Gastric emptying and release of incretin hormones after glucose ingestion in humans. Journal of Clinical Investigation 97, 92103.

K Vandewater & Z Vickers (1996) Higher protein foods produce greater sensory specific satiety. Physiology and Behavior 59, 579583.

T van Strien , JER Frijters , GPA Bergers & PB Defares (1986) The Dutch Eating Behaviour Questionnaire (DEBQ) for assessment of restrained, emotional, and external eating behaviour. International Journal of Eating Disorders 5, 295315.

C Verdich , A Flint , JP Gutzwiller , E Näslund , C Beglinger , PM Hellström , SJ Long , LM Morgan , JJ Holst & A Astrup (2001) A meta-analysis of the effect of glucagon-like peptide-1 (7–36) amide on ad libitum energy intake in humans. Journal of Clinical Endocrinology and Metabolism 86, 43824389.

SC Woods & D Porte Jr (1983) The role of insulin as a satiety factor in the central nervous system. Advances in Metabolic Disorders 10, 457467.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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