Hostname: page-component-76fb5796d-wq484 Total loading time: 0 Render date: 2024-04-26T08:41:34.665Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of protein deprivation on insulin-like growth factor-binding proteins in rats

Published online by Cambridge University Press:  09 March 2007

Tsutomu Umezawa ,
Yukiko Ohsawa ,
Yutaka Miura ,
Hisanori Kato  and
Tadashi Noguchi
Tsutomu Umezawa
Affiliation:
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan
Yukiko Ohsawa
Affiliation:
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan
Yutaka Miura
Affiliation:
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan
Hisanori Kato
Affiliation:
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan
Tadashi Noguchi
Affiliation:
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The effect of protein deprivation on plasma concentration of insulin-like growth factor-binding proteins (IGFBP) was studied in rats. A significant decrease in the concentration of IGFBP of molecular weight (mass) approximately 40 kDa was observed in protein-deprived rats. There was no prominent effect of protein deprivation on the concentration of IGFBP with molecular weights of about 30 kDa or 22–24 kDa. The binding capacity to plasma IGFBP of exogenously-added 125I-labelled insulin-like growth factor-1 (125I-IGF-1) was also studied. IGFBP of molecular weight about 30 and 22–24 kDa (the native form of this protein is presumed to be 29 kDa) in protein-deprived rat plasma bound more 125I-IGF-1 than those in protein-fed rat plasma. This suggested that these IGFBP in protein-deprived rat plasma are relatively unsaturated by endogenous IGF-1. The response of IGFBP to protein deprivation which was elucidated in the present investigations add further evidence to our previous assumption that IGFBP play an important role in protein nutrition.

Keywords

Insulin-like growth factor-1IGF-binding proteinProtein deprivationRat
Type
Hormonal Effects of Dietary Deprivation
Information
British Journal of Nutrition , Volume 66 , Issue 1 , July 1991 , pp. 105 - 116
Copyright
Copyright © The Nutrition Society 1991

References

REFERENCES

Albiston, A. L. & Herington, A. C. (1990). Cloning and characterization of the growth hormone-dependent insulin-like growth factor binding protein (IGFBP-3) in the rat. Biochemical and Biophysical Research Communications 166, 892–897.CrossRefGoogle ScholarPubMed
Ballard, J., Baxter, R., Binoux, M., Clemmons, D., Drop, S., Hall, K., Hintz, R., Rechler, M., Rutanen, E. & Schwander, J. (1989). On the nomenclature of the IGF binding proteins. Acta Endocrinologica 121, 751–752.Google ScholarPubMed
Bar, R. S., Booth, B. A., Boes, M. & Dake, B. L. (1989). Insulin-like growth factor-binding proteins from vascular endothelial cells: purification, characterization, and intrinsic biological activities. Endocrinology 125, 1910–1920.CrossRefGoogle ScholarPubMed
Baxter, R. C. (1988). Characterization of the acid-labile subunit of the growth hormone-dependent insulin-like growth factor binding protein complex. Journal of Clinical Endocrinology and Metabolism 67, 265–272.CrossRefGoogle ScholarPubMed
Baxter, R. C. & Cowell, C. T. (1987). Diurnal rhythm of growth hormone-independent binding protein for insulin-like growth factors in human plasma. Journal of Clinical Endocrinology and Metabolism 65, 432–440.CrossRefGoogle ScholarPubMed
Baxter, R. C., Martin, J. L. & Beniac, V. A. (1989). High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum. Journal of Biological Chemistry 264, 11843–11848.CrossRefGoogle ScholarPubMed
Baxter, R. C., Martin, J. L. & Wood, M. H. (1987). Two immunoreactive binding proteins for insulin-like growth factors in human amniotic fluid: Relationship to fetal maturity. Journal of Clinical Endocrinology and Metabolism 65, 423–431.CrossRefGoogle ScholarPubMed
Binoux, M., Hardouin, S., Lassarre, C. & Hossenlopp, P. (1982). Evidence for production by the liver of two IGF binding proteins with similar molecular weights but different affinities for IGF I and IGF II. Their relations with serum and cerebrospinal fluid IGF binding proteins. Journal of Clinical Endocrinology and Metabolism 55, 600–602.CrossRefGoogle ScholarPubMed
Binoux, M., Hossenlopp, P., Lassarre, C. & Hardouin, N. (1981). Production of insulin-like growth factors and their carrier by rat pituitary gland and brain explants in culture. FEBS Letters 124, 178–184.CrossRefGoogle ScholarPubMed
Blum, W. F., Jenne, E. W., Reppin, F., Kietzmann, K., Ranke, M. B. & Bierich, J. R. (1989). Insulin-like growth factor I (IGF-I)-binding protein complex is a better mitogen than free IGF-1. Endocrinology 125, 766–772.CrossRefGoogle Scholar
Brewer, M. T., Stetler, G. L., Squires, C. H., Thompson, R. C., Busby, W. H. & Clemmons, D. R. (1988). Cloning, characterization, and expression of a human insulin-like growth factor binding protein. Biochemical and Biophysical Research Communications 152, 1289–1297.CrossRefGoogle ScholarPubMed
Brown, A. L., Chiariotti, L., Orlowski, C. C., Mehlman, T., Burgess, W. H., Ackerman, E. J., Bruni, C. B. & Rechler, M. M. (1989). Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors. Journal of Biological Chemistry 264, 5148–5154.CrossRefGoogle ScholarPubMed
Busby, W. H., Hossenlopp, P., Binoux, M. & Clemmons, D. R. (1989). Purified preparations of the amniotic fluid-derived insulin-like growth factor-binding protein contain multimeric forms that are biologically active. Endocrinology 125, 773–777.CrossRefGoogle ScholarPubMed
Busby, W. H. Jr, Klapper, D. G. & Clemmons, D. R. (1988 a). Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions. Journal of Biological Chemistry 263, 14203–14210.CrossRefGoogle ScholarPubMed
Busby, W. H., Snyder, D. K. & Clemmons, D. R. (1988 b). Radioimmunoassay of a 26,000-dalton plasma insulin-like growth factor-binding protein: Control by nutritional variables. Journal of Clinical Endocrinology and Metabolism 67, 1225–1230.CrossRefGoogle ScholarPubMed
Cohen, K. L. & Nissley, S. P. (1975). Comparison of somatomedin activity in rat serum and lymph. Endocrinology 97, 654–658.CrossRefGoogle ScholarPubMed
Cornell, H. J., Enberg, G. & Herington, A. C. (1987). Preferential association of the insulin-like growth factors I and II with metabolically inactive and active carrier-bound complexes in serum. Biochemical Journal 241, 745–750.CrossRefGoogle ScholarPubMed
DeMellow, J. S. M. & Baxter, R. C. (1988). Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblasts. Biochemical and Biophysical Research Communications 156, 199–204.CrossRefGoogle Scholar
Drop, S. L. S., Kortleve, D. J. & Guyda, H. J. (1984). Isolation of a somatomedin-binding protein from preterm amniotic fluid. Development of a radioimmunoassay. Journal of Clinical Endocrinology and Metabolism 59, 899–907.CrossRefGoogle ScholarPubMed
Elgin, R. G., Busby, W. H. Jr. & Clemmons, D. R. (1987). An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I. Proceedings of National Academy of Sciences USA 84, 3254–3258.CrossRefGoogle ScholarPubMed
Froesch, E. R., Schmidt, C., Schwander, J. & Zapf, J. (1985). Actions of insulin-like growth factors. Annual Review of Physiology 47, 443–467.CrossRefGoogle ScholarPubMed
Furlanetto, R. W. (1980). The somatomedin C binding protein: Evidence for a heterologous subunit structure. Journal of Clinical Endocrinology and Metabolism 51, 12–19.CrossRefGoogle ScholarPubMed
Grant, M. B., Schmetz, I., Ressell, B., Harwood, H. J., Silverstein, J. Jr & Merimee, T. J. (1986). Changes in insulin-like growth factors I and II and their binding protein after a single intramuscular injection of growth hormone. Journal of Clinical Endocrinology and Metabolism 63, 981–984.CrossRefGoogle ScholarPubMed
Hardouin, S., Hossenlopp, P., Segovia, B., Seurin, D., Portolan, G., Lassarre, C. & Binoux, M. (1987). Heterogeneity of insulin-like growth factor binding proteins and relationships between structure and affinity. (1) Circulating forms in man. European Journal of Biochemistry 170, 121–132.CrossRefGoogle ScholarPubMed
Herington, A. C. & Kuffer, A. D. (1981). Identification of a specific inhibitor of nonsuppressible insulin-like activity in a partially purified human serum fraction. Endocrinology 109, 1634–1640.CrossRefGoogle Scholar
Hintz, R. L. & Liu, F. (1977). Demonstration of specific plasma protein binding sites for somatomedin. Journal of Clinical Endocrinology and Metabolism 45, 988–995.CrossRefGoogle ScholarPubMed
Hossenlopp, P., Seurin, D., Segovia-Quinson, B., Hardouin, S. & Binoux, M. (1986). Analysis of serum insulin-like growth factor binding proteins using western blotting: Use of the method for titration of the binding proteins and competitive binding studies. Analytical Biochemistry 154, 138–143.CrossRefGoogle ScholarPubMed
Kaufmann, U., Zapf, J. & Froesch, E. R. (1978). Growth-hormone dependence of non-suppressible insulin-like activity (NSILA) and of NSILA-carrier protein in rats. Acta Endocrinologica 87, 716–727.Google ScholarPubMed
Kaufmann, U., Zapf, J., Torretti, B. & Froesch, E. R. (1977). Demonstration of a specific serum carrier protein of non-suppressible insulin-like activity in vivo. Journal of Clinical Endocrinology and Metabolism 44, 160–166.CrossRefGoogle Scholar
Knauer, D. J. & Smith, G. L. (1980). Inhibition of biological activity of multiplication-stimulating activity by binding to its carrier protein. Proceedings of National Academy of Sciences USA 77, 7252–7256.CrossRefGoogle ScholarPubMed
Koistinen, R., Kalkkinen, N., Huhtala, M. L., Seppala, M., Bohn, H. & Rutanen, E. M. (1986). Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid. Endocrinology 118, 1375–1378.CrossRefGoogle ScholarPubMed
Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680–685.CrossRefGoogle ScholarPubMed
Lee, Y. L., Hintz, R. L., James, P. M., Lee, P. D. K., Shively, J. E. & Powell, D. R. (1988). Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: Predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors. Molecular Endocrinology 2, 404–411.CrossRefGoogle ScholarPubMed
LeRoith, D. & Raizada, M. K. (editors) (1989). Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. New York and London: Plenum Press.CrossRefGoogle Scholar
Martin, J. L. & Baxter, R. C. (1985). Antibody against acid-stable insulin-like growth factor binding protein detects 150,000 mol wt growth hormone-dependent complex in human plasma. Journal of Clinical Endocrinology and Metabolism 61, 799–801.CrossRefGoogle Scholar
Martin, J. L. & Baxter, R. C. (1986). Insulin-like growth factor-binding protein from human plasma. Purification and characterization. Journal of Biological Chemistry 261, 8754–8760.CrossRefGoogle ScholarPubMed
Moses, A. C., Nissley, S. P. & Cohen, K. L. (1976). Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone. Nature 263, 137–140.CrossRefGoogle ScholarPubMed
Moses, A. C., Nissley, S. P., Passamani, J. & White, R. M. (1979). Further characterization of growth hormone-dependent somatomedin-binding proteins in rat serum and demonstration of somatomedin-binding proteins produced by rat liver cells in culture. Endocrinology 104, 536–546.CrossRefGoogle ScholarPubMed
Ooi, G. T. & Herrington, A. C. (1986). Covalent cross-linking of insulin-like growth factor-I to a specific inhibitor from human serum. Biochemical and Biophysical Research Communications 137, 411–417.CrossRefGoogle ScholarPubMed
Ooi, G. T. & Herrington, A. C. (1988). Recognition of insulin-like growth factor (IGF) serum binding proteins by an antibody raised against a specific IGF-inhibitor. Biochemical and Biophysical Research Communications 156, 783–791.CrossRefGoogle ScholarPubMed
Povoa, G., Enberg, G., Jornvall, H. & Hall, K. (1984). Isolation and characterization of a somatomedin-binding protein from mid-term human amniotic fluid. European Journal of Biochemistry 144, 199–204.CrossRefGoogle ScholarPubMed
Rechler, M. W., Brown, A. L., Orlowski, C. C., Yang, Y. W. -H., Romanus, J. A., Chiariotti, L. & Bruni, C. B. (1989 a). Characterization and cloning of a rat insulin-like growth factor binding protein. In Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors, pp. 395–402 [LeRoith, D. and Raizada, M. K., editors]. New York and London: Plenum Press.CrossRefGoogle Scholar
Rechler, M. M., Yang, Y. W. -H., Brown, A. L., Orlowski, C. C. and Ooi, G. T. (1989 b). Molecular characterization of insulin-like growth factor binding proteins in the rat. In Insulin-like Growth Factor Binding Proteins, pp. 133–142 [Drop, S. L. S. and Hintz, R. L., editors]. Amsterdam–New York–Oxford: Excerpta Medica.Google Scholar
Ritvos, O., Ranta, T., Jalkanen, J., Suikkari, A. M., Voutilainen, R., Bohn, H. & Rutanen, E. M. (1988). Insulin-like growth factor (IGF) binding protein from human decidua inhibits the binding and biological action of IGF-I in cultured choriocarcinoma cells. Endocrinology 122, 2150–2157.CrossRefGoogle ScholarPubMed
Rosenfeld, R. G., Pham, H., Conover, C. A., Hintz, R. L. & Baxter, R. C. (1989). Structural and immunological comparison of insulin-like growth factor binding proteins of cerebrospinal and amniotic fluids. Journal of Clinical Endocrinology and Metabolism 68, 638–646.CrossRefGoogle ScholarPubMed
Rutanen, E. M., Koistinen, R., Sjoberg, J., Julkunen, M., Wahlstrom, T., Bohn, H. & Seppala, M. (1986). Synthesis of placental protein 12 by human endometrium. Endocrinology 118, 1067–1071.CrossRefGoogle ScholarPubMed
Rutanen, E. M., Koistinen, R., Wahlstrom, T., Bohn, H., Ranta, T. & Seppala, M. (1985). Synthesis of placental protein 12 by human decidua. Endocrinology 116, 1304–1309.CrossRefGoogle ScholarPubMed
Schmid, C., Ernst, M., Zapf, J. & Froesch, E. R. (1989). Release of insulin-like growth factor carrier proteins by osteoblasts: stimulation by estradiol and growth hormone. Biochemical and Biophysical Research Communications 160, 788–794.CrossRefGoogle ScholarPubMed
Snedecor, G. W. & Cochran, W. G. (1967). One-way classifications. Analysis of variance. In Statistical Methods, 6th ed., pp. 271–273. Ames Iowa: Iowa State University Press.Google Scholar
Takahashi, S., Kajikawa, M., Umezawa, T., Takahashi, S.-I., Kato, H., Miura, Y., Nam, T. J., Noguchi, T. & Naito, H. (1990). Effect of dietary proteins on the plasma immunoreactive insulin-like growth factor- 1/somatomedin C concentration in the rat. British Journal of Nutrition 63, 521–534.CrossRefGoogle ScholarPubMed
Van Wyk, J. J. (1984). The somatomedins: Biological actions and physiologic control mechanisms. In Hormonal Proteins and Peptides, vol. 12, pp. 81–125.Google Scholar
Wang, J. F., Hampton, B., Mehlman, T., Burgess, W. H. & Rechler, M. M. (1988). Isolation of a biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors. Biochemical and Biophysical Research Communications 157, 718–726.CrossRefGoogle ScholarPubMed
White, R. M., Nissley, S. P., Moses, A. C., Rechler, M. M. & Johnsonbaugh, R. E. (1981). The growth hormone dependence of a somatomedin-binding protein in human serum. Journal of Clinical Endocrinology and Metabolism 53, 49–57.CrossRefGoogle ScholarPubMed
Wilkins, J. R. & D'Ercole, A. J. (1985). Affinity-labeled plasma somatomedin-C/insulin-like growth factor I binding proteins. Journal of Clinical Investigation 75, 1350–1358.CrossRefGoogle Scholar
Yang, Y. W.-H., Wang, J.-F., Orlowski, C. C., Nissley, S. P. & Rechler, M. M. (1989). Structure, specificity, and regulation of the insulin-like growth factor-binding proteins in adult rat serum. Endocrinology 125, 1540–1555.CrossRefGoogle ScholarPubMed