Skip to main content
×
Home
    • Aa
    • Aa

The effects of concentrated barley β-glucan on blood lipids in a population of hypercholesterolaemic men and women

  • Joseph M. Keenan (a1), Melanie Goulson (a2), Tatyana Shamliyan (a1), Nathan Knutson (a2), Lore Kolberg (a2) and Leslie Curry (a2)...
Abstract

Barley, like oats, is a rich source of the soluble fibre β-glucan, which has been shown to significantly lower LDL-cholesterol (LDL-C). However, barley foods have been less widely studied. Therefore, we evaluated the LDL-C-lowering effect of a concentrated barley β-glucan (BBG) extract as a vehicle to deliver this potential health benefit of barley. In a 10-week blinded controlled study, subjects were randomized to one of four treatment groups or control. Treatment groups included either high molecular weight (HMW) or low molecular weight (LMW) BBG at both 3 and 5 g doses. Treatment was delivered twice per day with meals in the form of two functional food products: a ready-to-eat cereal and a reduced-calorie fruit juice beverage. Levels of total cholesterol, LDL-C, HDL-cholesterol (HDL-C), and TAG were determined at baseline and after 6 weeks of treatment. The study group comprised 155 subjects. All treatments were well tolerated and after 6 weeks of treatment the mean LDL-C levels fell by 15 % in the 5 g HMW group, 13 % in the 5 g LMW group and 9 % in both the 3 g/d groups, versus baseline. Similar results were observed for total cholesterol. HDL-C levels were unchanged by treatment. Concentrated BBG significantly improves LDL-C and total cholesterol among moderately dyslipidaemic subjects. Food products containing concentrated BBG should be considered an effective option for improving blood lipids.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The effects of concentrated barley β-glucan on blood lipids in a population of hypercholesterolaemic men and women
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      The effects of concentrated barley β-glucan on blood lipids in a population of hypercholesterolaemic men and women
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      The effects of concentrated barley β-glucan on blood lipids in a population of hypercholesterolaemic men and women
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Joseph M. Keenan, MD, fax 612-625-0640, keena001@umn.edu
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

LA Bazzano , J He , LG Ogden , CM Loria & PK Whelton (2003) Dietary fiber intake and reduced risk of coronary heart disease in US men and women: the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Arch Intern Med 163, 18971904.

KM Behall , DJ Scholfield & J Hallfrisch (1997) Effect of beta-glucan level in oat fiber extracts on blood lipids in men and women. J Am Coll Nutr 16, 4651.

KM Behall , DJ Scholfield & J Hallfrisch (2004 b) Lipids significantly reduced by diets containing barley in moderately hypercholesterolemic men. J Am Coll Nutr 23, 5562.

DR Jacobs Jr & DD Gallaher (2004) Whole grain intake and cardiovascular disease: a review. Curr Atheroscler Rep 6, 415423.

JA Marlett , KB Hosig , NW Vollendorf , FL Shinnick , VS Haack & JA Story (1994) Mechanism of serum cholesterol reduction by oat bran. Hepatology 20, 14501457.

National Cholesterol Education Program (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285, 24862497.

AS Truswell (1995) Dietary fibre and blood lipids. Curr Opin Lipidol 6, 1419.

K Yamada , Y Tokunaga , A Ikeda , (1999) Dietary effect of guar gum and its partially hydrolyzed product on the lipid metabolism and immune function of Sprague-Dawley rats. Biosci Biotechnol Biochem 63, 21632167.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 25
Total number of PDF views: 152 *
Loading metrics...

Abstract views

Total abstract views: 243 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 25th July 2017. This data will be updated every 24 hours.