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Elevated erythrocyte phosphoribosylpyrophosphate and ATP concentrations in Japanese sumo wrestlers

Published online by Cambridge University Press:  09 March 2007

Y. Nishida ,
I. Akaoka ,
E. Hayashi  and
T. Miyamoto
Y. Nishida
Affiliation:
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan 113
I. Akaoka
Affiliation:
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan 113
E. Hayashi
Affiliation:
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan 113
T. Miyamoto
Affiliation:
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan 113
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Abstract

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1. Japanese sumo wrestlers have a diet rich in energy, which results in marked obesity. Their plasma urate and triglyceride levels were significantly elevated.

2. Erythrocyte phosphoribosylpyrophosphate (PRPP) and ATP concentrations in sumo wrestlers were significantly elevated when compared to the levels in control subjects.

3. There were no significant differences in erythrocyte PRPP synthetase (EC 2.7.6.1), purine nucleoside phosphorylase (EC 2.4.2.1) and hypoxanthine guanine phosphoribosyl transferase (EC 2.4.2.8) activities between sumo wrestlers and control subjects.

4. Erythrocyte adenosine kinase (EC 2.7.1.20), adenosine deaminase (EC 3.5.4.4) and adenine phosphoribosyl transferase (EC 2.4.2.7) activities in sumo wrestlers were significantly elevated.

5. It seems that sumo wrestlers have an increased turnover of adenine nucleotides which may contribute to hyperuricaemia.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 49 , Issue 1 , January 1983 , pp. 3 - 7
Copyright
Copyright © The Nutrition Society 1983

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