Hostname: page-component-76fb5796d-qxdb6 Total loading time: 0 Render date: 2024-04-26T23:33:08.592Z Has data issue: false hasContentIssue false
  • English
  • Français

Experimental protein-energy malnutrition in baby baboons

2.* Liver pathology

Published online by Cambridge University Press:  09 March 2007

R. S. Patrick ,
A. M. Mackay ,
Dorothy G. Coward  and
R. G. Whitehead
R. S. Patrick
Affiliation:
Glasgow University Department of Pathology, Royal Infirmary, Glasgow, G4 oSF
A. M. Mackay
Affiliation:
Glasgow University Department of Pathology, Royal Infirmary, Glasgow, G4 oSF
Dorothy G. Coward
Affiliation:
Medical Research Coucil Child Nutrition Unit, PO Box 6717, Kampala, Uganda
R. G. Whitehead
Affiliation:
Medical Research Coucil Child Nutrition Unit, PO Box 6717, Kampala, Uganda
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Liver biopsies were performed through laparotomy wounds in six baby baboons during the development of a kwashiorkor-like illness induced by low-protein, high-carbohydrate diets similar to those consumed by many East African children. Up to six biopsies have been performed successfully in one animal within a period of 1 year. This material has been studied by light and electron microscopy.

2. A similar study was carried out in two healthy animals fed on an adequate diet. A description is given of liver ultrastructure in normal baby baboons, based on examination of these biopsies.

3. The hepatocytes of the malnourished animals contained excessive amounts of glycogen and showed a reduction in rough and smooth endoplasmic reticulum. Even at the height of an illness indistinguishable clinically from marasmic kwashiorkor, there was no excess of liver fat except in those animals whose diet contained sucrose. This may have been the result of stimulation of hepatic triglyceride synthesis by fructose.

4. In no specimen from the experimental group were there signs of serious progressive and irreversible liver cell damage which might have been expected if liver dysfunction were an important component of kwashiorkor.

5. Biopsies performed in one malnourished animal during recovery showed a return of liver ultrastructure to normal.

Type
Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 30 , Issue 2 , September 1973 , pp. 171 - 179
Copyright
Copyright © The Nutrition Society 1973

References

Becker, K. (1971). Klin. Wschr. 49, 558.CrossRefGoogle Scholar
Bras, G., Goldblatt, H. & Gyürgy, I. (1959). Br. J. exp. Path. 40, 172.Google Scholar
Camain, R., Rouiller, C. & Supin, H. (1959). Ann. Anat. Path. 4, 220.Google Scholar
Campbell, J. A. H. (1956). Archs Dis. Childh. 31, 310.CrossRefGoogle Scholar
Coltart, T. M. & Crossley, J. N. (1970). Clin Sci. 38, 427.CrossRefGoogle Scholar
Coward, D. G. & Whitehead, R. G. (1972). Br. J. Nutr. 28, 223.Google Scholar
Crossley, J. N. & Macdonald, I. (1970). Exp. mol Path. 12, 171.Google Scholar
Enwonwu, C. O. & Sreebny, L. M. (1970). Exp. mol Path. 12, 332.CrossRefGoogle Scholar
Enwonwu, C. O. & Sreebny, L. M. (1971). J. Nutr. 101, 501.CrossRefGoogle Scholar
Ericsson, J. L. E., Orrenius, S. & Holm, I. (1966). Exp. mol. Path. 5, 329.CrossRefGoogle Scholar
Fletcher, K. (1966). Am. J. clin. Nutr. 19, 170.CrossRefGoogle Scholar
Flores, H., Pak, N., Maccioni, A. & Monckeberg, F. (1970). Br. J. Nutr. 24, 1005.CrossRefGoogle Scholar
Fuller, R. W. & Diller, E. R. (1970). Metabolism 19, 226.Google Scholar
Garrow, J. S., Fletcher, K. & Halliday, D. (1965). J. clin Invest. 44, 417.CrossRefGoogle Scholar
Grimble, R. F. & Whitehead, R. G. (1971). Br. J. Nutr. 25, 253.Google Scholar
Higginson, J., Grobbelaar, B. G. & Walker, A. R. P. (1957). Am. J. Path. 33, 29.Google Scholar
Kornacker, M. S. & Lowenstein, J. M. (1965). Biochem. J. 95, 832.Google Scholar
Rohr, H. P., Hundstad, A. -C., Bianchi, L. & Eckert, H. (1970). Acta anat. 76, 102.Google Scholar
Schaffner, F. & Popper, H. (1963). Gastroenterology 44, 239.Google Scholar
Smith, C. E. (1962). J. Pediat. 61, 617.Google Scholar
Svoboda, D. & Higginson, J. (1964). Am. J. Path. 45, 353.Google Scholar
Theron, J. J. & Liebenberg, N. (1963). J. Path. Bact. 86, 353.CrossRefGoogle Scholar
Truswell, A. S., Hansen, J. D. L., Watson, C. E. & Wannenburg, P. (1969). Am. J. clin. Nutr. 22, 568.CrossRefGoogle Scholar
Waterlow, J. C. (1961–2). Proc. R. Soc. B 155, 96.Google Scholar
Waterlow, J. C. & Weisz, T. (1956). J. clin. Invest. 35, 346.CrossRefGoogle Scholar