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Is reversal of endothelial dysfunction by tea related to flavonoid metabolism?

  • Jonathan M. Hodgson (a1), Ian B. Puddey (a1), Valerie Burke (a1) and Kevin D. Croft (a1)
  • DOI: http://dx.doi.org/10.1079/BJN20051621
  • Published online: 01 March 2007
Abstract

Dietary flavonoids can improve endothelial function, but the response varies between individuals. Wide variability is also seen in flavonoid O-methylation, a major pathway of flavonoid metabolism. The O-methylation of flavonoids could alter activity, and thus influence any effect on endothelial function. The objective of the current analysis was to investigate whether variability in the endothelial function response to ingestion of tea, a rich source of flavonoids, is related to the degree of O-methylation of flavonoids. This relationship was investigated in two studies in which endothelium-dependent flow-mediated dilatation (FMD) of the brachial artery was assessed and urinary 4-O-methylgallic acid (4OMGA) excretion was used as a marker of the O-methylation of tea-derived flavonoids. In the first study, amongst participants consuming five cups of tea per day for 4 weeks, the degree of increase in 4OMGA excretion was inversely associated with the change in FMD responses (r −078, p=0·008). In the second study, there was a significant difference in the FMD responses to acute ingestion of three cups of tea between individuals with a low (<median) and high (>median) 4OMGA response (1·94 (sem 0·79) % and −0·25 (sem 0·53) %, respectively; p=0·03). That is, any improvement in FMD following ingestion of tea may be enhanced in individuals who O-methylate less of the absorbed flavonoids. The present results are consistent with the suggestion that differences in flavonoid metabolism may influence their effect on endothelial function. Thus, differences in flavonoid metabolism could be related to the level of benefit of dietary flavonoids on the risk of CVD.

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Corresponding author
*Corresponding author: Dr Jonathan M. Hodgson, University of Western Australia, fax +61 8 9224 0246, email jonathan@cyllene.uwa.edu.au
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MC Corretti , TJ Anderson EJ Benjamin Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force J Am Coll Cardiol (2002) 39 257265

AM Cuevas , V Guasch , O Castillo , V Irribarra , C Mizon , A San Martin , P Strobel , D Perez , AM Germain & F Leighton A highfat diet induces and red wine counteracts endothelial dysfunction in human volunteers. Lipids (2000) 35 143148

SJ Duffy , JF Keaney Jr M Holbrook , N Gokce , PL Swerdloff , B Frei & JA Vita Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease Circulation (2001) 104 151156

DF Fitzpatrick , SL Hirshfield , T Ricci , P Jantzen & RG Coffey Endothelium-dependent vasorelaxation caused by various plant extracts J Cardiovasc Pharmacol (1995) 26 9095

C Heiss , A Dejam , P Kleinbongard , T Schewe , H Sies & M Kelm Vascular effects of cocoa rich in flavan-3-ols JAMA (2003) 290 10301031

JM Hodgson , V Burke & IB Puddey Acute effects of tea on fasting and postprandial vascular function and blood pressure in humans. J Hypertens (2005) 23 4754

JM Hodgson , LW Morton , IB Puddey , LJ Beilin & KD Croft Gallic acid metabolites are markers of black tea intake in humans J Agric Food Chem (2000) 48 22762280

JM Hodgson , IB Puddey , V Burke , GF Watts & LJ Beilin Regular ingestion of black tea improves brachial artery vasodilator function. Clin Sci (2002) 102 195201

U Landmesser B Hornig & H Drexler Endothelial function: a critical determinant in atherosclerosis?“ Circulation (2004) 109 II27II33

H Lu , X Meng & CS Yang Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (2)- epigallocatechin gallate. Drug Metab Disp (2003) 31 572579

F Nanjo , K Goto , R Seto , M Suzuki , M Sakai & Y Hara Scavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical Free Rad Biol Med (1996) 21 895902

JH Stein , JG Keevil , DA Wiebe , S Aeschlimann JD Folts Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease Circulation (1999) 100 10501055

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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