Skip to main content
    • Aa
    • Aa
  • Access
  • Cited by 21
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Ferreira, M.A. Silva, D.M. de Morais, A.C. Mota, J.F. and Botelho, P.B. 2016. Therapeutic potential of green tea on risk factors for type 2 diabetes in obese adults - a review. Obesity Reviews,

    Janssens, Pilou L.H.R. Hursel, Rick and Westerterp-Plantenga, Margriet S. 2016. Nutraceuticals for body-weight management: The role of green tea catechins. Physiology & Behavior, Vol. 162, p. 83.

    Türközü, Duygu and Acar Tek, Nilüfer 2015. A Minireview of Effects of Green Tea on Energy Expenditure. Critical Reviews in Food Science and Nutrition, p. 00.

    Lorenz, Mario Paul, Friedemann Moobed, Minoo Baumann, Gert Zimmermann, Benno F. Stangl, Karl and Stangl, Verena 2014. The activity of catechol-O-methyltransferase (COMT) is not impaired by high doses of epigallocatechin-3-gallate (EGCG) in vivo. European Journal of Pharmacology, Vol. 740, p. 645.

    Dreher, Mark 2012. Innovation in Healthy and Functional Foods.

    Ruxton, C. H. S. and Mason, P. 2012. Is black tea consumption associated with a lower risk of cardiovascular disease and type 2 diabetes?. Nutrition Bulletin, Vol. 37, Issue. 1, p. 4.

    Brown, A. L. Lane, J. Holyoak, C. Nicol, B. Mayes, A. E. and Dadd, T. 2011. Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial. British Journal of Nutrition, Vol. 106, Issue. 12, p. 1880.

    Hursel, R. Viechtbauer, W. Dulloo, A. G. Tremblay, A. Tappy, L. Rumpler, W. and Westerterp-Plantenga, M. S. 2011. The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis. Obesity Reviews, Vol. 12, Issue. 7, p. e573.

    Miller, Rosalind J. Jackson, Kim G. Dadd, Tony Mayes, Andrew E. Louise Brown, A. and Minihane, Anne M. 2011. The impact of the catechol- O-methyltransferase genotype on the acute responsiveness of vascular reactivity to a green tea extract. British Journal of Nutrition, Vol. 105, Issue. 08, p. 1138.

    Hursel, R and Westerterp-Plantenga, M S 2010. Thermogenic ingredients and body weight regulation. International Journal of Obesity, Vol. 34, Issue. 4, p. 659.

    Sánchez-Salgado, Juan Carlos Castillo-España, Patricia Ibarra-Barajas, Maximiliano Villalobos-Molina, Rafael and Estrada-Soto, Samuel 2010. Cochlospermum vitifolium induces vasorelaxant and antihypertensive effects mainly by activation of NO/cGMP signaling pathway. Journal of Ethnopharmacology, Vol. 130, Issue. 3, p. 477.

    Westerterp-Plantenga, M.S. 2010. Green tea catechins, caffeine and body-weight regulation. Physiology & Behavior, Vol. 100, Issue. 1, p. 42.

    Hursel, Rick and Westerterp-Plantenga, Margriet 2009. Weight Control and Slimming Ingredients in Food Technology.

    Hursel, R Viechtbauer, W and Westerterp-Plantenga, M S 2009. The effects of green tea on weight loss and weight maintenance: a meta-analysis. International Journal of Obesity, Vol. 33, Issue. 9, p. 956.

    Wei, Shu-Qin Xu, Hairong Xiong, Xu Luo, Zhong-Cheng Audibert, Francois and Fraser, William D. 2009. Tea consumption during pregnancy and the risk of pre-eclampsia. International Journal of Gynecology & Obstetrics, Vol. 105, Issue. 2, p. 123.

    Gardner, E J Ruxton, C H S and Leeds, A R 2007. Black tea – helpful or harmful? A review of the evidence. European Journal of Clinical Nutrition, Vol. 61, Issue. 1, p. 3.

    Mukamal, Kenneth J. MacDermott, Kristen Vinson, Joe A. Oyama, Noriko Manning, Warren J. and Mittleman, Murray A. 2007. A 6-month randomized pilot study of black tea and cardiovascular risk factors. American Heart Journal, Vol. 154, Issue. 4, p. 724.e1.

    Stanner, S. 2007. Does adding milk remove the benefits of your daily cuppa?. Nutrition Bulletin, Vol. 32, Issue. 2, p. 101.

    Hodgson, Jonathan M and Croft, Kevin D 2006. Dietary flavonoids: effects on endothelial function and blood pressure. Journal of the Science of Food and Agriculture, Vol. 86, Issue. 15, p. 2492.

    Hodgson, JM 2006. EFFECTS OF TEA AND TEA FLAVONOIDS ON ENDOTHELIAL FUNCTION AND BLOOD PRESSURE: A BRIEF REVIEW. Clinical and Experimental Pharmacology and Physiology, Vol. 33, Issue. 9, p. 838.


Is reversal of endothelial dysfunction by tea related to flavonoid metabolism?

  • Jonathan M. Hodgson (a1), Ian B. Puddey (a1), Valerie Burke (a1) and Kevin D. Croft (a1)
  • DOI:
  • Published online: 01 March 2007

Dietary flavonoids can improve endothelial function, but the response varies between individuals. Wide variability is also seen in flavonoid O-methylation, a major pathway of flavonoid metabolism. The O-methylation of flavonoids could alter activity, and thus influence any effect on endothelial function. The objective of the current analysis was to investigate whether variability in the endothelial function response to ingestion of tea, a rich source of flavonoids, is related to the degree of O-methylation of flavonoids. This relationship was investigated in two studies in which endothelium-dependent flow-mediated dilatation (FMD) of the brachial artery was assessed and urinary 4-O-methylgallic acid (4OMGA) excretion was used as a marker of the O-methylation of tea-derived flavonoids. In the first study, amongst participants consuming five cups of tea per day for 4 weeks, the degree of increase in 4OMGA excretion was inversely associated with the change in FMD responses (r −078, p=0·008). In the second study, there was a significant difference in the FMD responses to acute ingestion of three cups of tea between individuals with a low (<median) and high (>median) 4OMGA response (1·94 (sem 0·79) % and −0·25 (sem 0·53) %, respectively; p=0·03). That is, any improvement in FMD following ingestion of tea may be enhanced in individuals who O-methylate less of the absorbed flavonoids. The present results are consistent with the suggestion that differences in flavonoid metabolism may influence their effect on endothelial function. Thus, differences in flavonoid metabolism could be related to the level of benefit of dietary flavonoids on the risk of CVD.

    • Send article to Kindle

      To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Is reversal of endothelial dysfunction by tea related to flavonoid metabolism?
      Your Kindle email address
      Available formats
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Is reversal of endothelial dysfunction by tea related to flavonoid metabolism?
      Available formats
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Is reversal of endothelial dysfunction by tea related to flavonoid metabolism?
      Available formats
Corresponding author
*Corresponding author: Dr Jonathan M. Hodgson, University of Western Australia, fax +61 8 9224 0246, email
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

MC Corretti , TJ Anderson EJ Benjamin Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force J Am Coll Cardiol (2002) 39 257265

AM Cuevas , V Guasch , O Castillo , V Irribarra , C Mizon , A San Martin , P Strobel , D Perez , AM Germain & F Leighton A highfat diet induces and red wine counteracts endothelial dysfunction in human volunteers. Lipids (2000) 35 143148

SJ Duffy , JF Keaney Jr M Holbrook , N Gokce , PL Swerdloff , B Frei & JA Vita Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease Circulation (2001) 104 151156

DF Fitzpatrick , SL Hirshfield , T Ricci , P Jantzen & RG Coffey Endothelium-dependent vasorelaxation caused by various plant extracts J Cardiovasc Pharmacol (1995) 26 9095

C Heiss , A Dejam , P Kleinbongard , T Schewe , H Sies & M Kelm Vascular effects of cocoa rich in flavan-3-ols JAMA (2003) 290 10301031

JM Hodgson , V Burke & IB Puddey Acute effects of tea on fasting and postprandial vascular function and blood pressure in humans. J Hypertens (2005) 23 4754

JM Hodgson , LW Morton , IB Puddey , LJ Beilin & KD Croft Gallic acid metabolites are markers of black tea intake in humans J Agric Food Chem (2000) 48 22762280

JM Hodgson , IB Puddey , V Burke , GF Watts & LJ Beilin Regular ingestion of black tea improves brachial artery vasodilator function. Clin Sci (2002) 102 195201

U Landmesser B Hornig & H Drexler Endothelial function: a critical determinant in atherosclerosis?“ Circulation (2004) 109 II27II33

H Lu , X Meng & CS Yang Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (2)- epigallocatechin gallate. Drug Metab Disp (2003) 31 572579

F Nanjo , K Goto , R Seto , M Suzuki , M Sakai & Y Hara Scavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical Free Rad Biol Med (1996) 21 895902

JH Stein , JG Keevil , DA Wiebe , S Aeschlimann JD Folts Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease Circulation (1999) 100 10501055

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *