Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 19
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Kim, Jung Eun O’Connor, Lauren E. Sands, Laura P. Slebodnik, Mary B. and Campbell, Wayne W. 2016. Effects of dietary protein intake on body composition changes after weight loss in older adults: a systematic review and meta-analysis. Nutrition Reviews, Vol. 74, Issue. 3, p. 210.


    Liu, Yi-Lien Lu, Chia-Wen Shi, Leiyu Liou, Yiing-Mei Lee, Long-Teng and Huang, Kuo-Chin 2015. Low Intensive Lifestyle Modification in Young Adults With Metabolic Syndrome A Community-Based Interventional Study in Taiwan. Medicine, Vol. 94, Issue. 22, p. e916.


    Nowson, Caryl Lim, Karen Grimes, Carley O’Halloran, Siobhan Land, Mary Webster, Jacqui Shaw, Jonathan Chalmers, John Smith, Wayne Flood, Victoria Woodward, Mark and Neal, Bruce 2015. Dietary Salt Intake and Discretionary Salt Use in Two General Population Samples in Australia: 2011 and 2014. Nutrients, Vol. 7, Issue. 12, p. 10501.


    Varady, Krista A. Dam, Vi T. Klempel, Monica C. Horne, Matthew Cruz, Rani Kroeger, Cynthia M. and Santosa, Sylvia 2015. Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles. Scientific Reports, Vol. 5, p. 7561.


    Clifton, P.M. Condo, D. and Keogh, J.B. 2014. Long term weight maintenance after advice to consume low carbohydrate, higher protein diets – A systematic review and meta analysis. Nutrition, Metabolism and Cardiovascular Diseases, Vol. 24, Issue. 3, p. 224.


    Sinnett, Stephanie Lowndes, Joshua Nguyen, Von Lv, Nan and Rippe, James 2014. High Fructose Corn Syrup and Sucrose Sweetened Milk Improve Dietary Quality during Weight Loss by Displacing Energy Dense, Nutrient Poor Foods. Food and Nutrition Sciences, Vol. 05, Issue. 11, p. 1005.


    Margerison, Claire Riddell, Lynnette J. Wattanapenpaiboon, Naiyana and Nowson, Caryl A. 2013. Dietary sources and meal distribution of sodium and potassium in a sample of Australian adults. Nutrition & Dietetics, Vol. 70, Issue. 4, p. 294.


    Fogelholm, Mikael Anderssen, Sigmund Gunnarsdottir, Ingibjörg and Lahti-Koski, Marjaana 2012. Dietary macronutrients and food consumption as determinants of long-term weight change in adult populations: a systematic literature review. Food & Nutrition Research, Vol. 56,


    Lowndes, Joshua Kawiecki, Diana Pardo, Sabrina Nguyen, Von Melanson, Kathleen J Yu, Zhiping and Rippe, James M 2012. The effects of four hypocaloric diets containing different levels of sucrose or high fructose corn syrup on weight loss and related parameters. Nutrition Journal, Vol. 11, Issue. 1,


    Bladbjerg, Else-Marie Larsen, Thomas M. Due, Anette Stender, Steen Astrup, Arne and Jespersen, Jørgen 2011. Effects on markers of inflammation and endothelial cell function of three ad libitum diets differing in type and amount of fat and carbohydrate: a 6-month randomised study in obese individuals. British Journal of Nutrition, Vol. 106, Issue. 01, p. 123.


    Schwingshackl, L. Strasser, B. and Hoffmann, G. 2011. Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis. Annals of Nutrition and Metabolism, Vol. 58, Issue. 4, p. 290.


    Schwingshackl, L. Strasser, B. and Hoffmann, G. 2011. Effects of Monounsaturated Fatty Acids on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. Annals of Nutrition and Metabolism, Vol. 59, Issue. 2-4, p. 176.


    Abete, Itziar Astrup, Arne Martínez, J Alfredo Thorsdottir, Inga and Zulet, Maria A 2010. Obesity and the metabolic syndrome: role of different dietary macronutrient distribution patterns and specific nutritional components on weight loss and maintenance. Nutrition Reviews, Vol. 68, Issue. 4, p. 214.


    Flechtner-Mors, Marion Boehm, Bernhard O. Wittmann, Regina Thoma, Ulrike and Ditschuneit, Herwig H. 2010. Enhanced weight loss with protein-enriched meal replacements in subjects with the metabolic syndrome. Diabetes/Metabolism Research and Reviews, Vol. 26, Issue. 5, p. 393.


    Pettman, Tahna L. Buckley, Jonathan D. Misan, Gary M.H. Coates, Alison M. and Howe, Peter R.C. 2009. Health benefits of a 4-month group-based diet and lifestyle modification program for individuals with metabolic syndrome. Obesity Research & Clinical Practice, Vol. 3, Issue. 4, p. 221.


    Sacks, Frank M. Bray, George A. Carey, Vincent J. Smith, Steven R. Ryan, Donna H. Anton, Stephen D. McManus, Katherine Champagne, Catherine M. Bishop, Louise M. Laranjo, Nancy Leboff, Meryl S. Rood, Jennifer C. de Jonge, Lilian Greenway, Frank L. Loria, Catherine M. Obarzanek, Eva and Williamson, Donald A. 2009. Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates. New England Journal of Medicine, Vol. 360, Issue. 9, p. 859.


    Brehm, Bonnie J and DʼAlessio, David A 2008. Benefits of high-protein weight loss diets: enough evidence for practice?. Current Opinion in Internal Medicine, Vol. 7, Issue. 6, p. 566.


    Brehm, Bonnie J and DʼAlessio, David A 2008. Benefits of high-protein weight loss diets: enough evidence for practice?. Current Opinion in Endocrinology, Diabetes and Obesity, Vol. 15, Issue. 5, p. 416.


    NOAKES, Manny KEOGH, Jennifer and CLIFTON, Peter 2007. Obesity and type 2 diabetes mellitus. Nutrition & Dietetics, Vol. 64, Issue. s4 The Role of, p. S156.


    ×

Long-term weight maintenance and cardiovascular risk factors are not different following weight loss on carbohydrate-restricted diets high in either monounsaturated fat or protein in obese hyperinsulinaemic men and women

  • Jennifer B. Keogh (a1), Natalie D. Luscombe-Marsh (a2), Manny Noakes (a1), Gary A. Wittert (a2) and Peter M. Clifton (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114507252687
  • Published online: 01 February 2007
Abstract

The aim of this study was to determine after 52 weeks whether advice to follow a lower carbohydrate diet, either high in monounsaturated fat or low fat, high in protein had differential effects in a free-living community setting. Following weight loss on either a high monounsaturated fat, standard protein (HMF; 50 % fat, 20 % protein (67 g/d), 30 % carbohydrate) or a high protein, moderate fat (HP) (40 % protein (136 g/d), 30 % fat, 30 % carbohydrate) energy-restricted diet (6000 kJ/d) subjects were asked to maintain the same dietary pattern without intensive dietary counselling for the following 36 weeks. Overall weight loss was 6·2 (sd 7·3) kg (P < 0·01 for time with no diet effect, 7·6 (sd 8·1) kg, HMF v. 4·8 (sd 6·6) kg, HP). In a multivariate regression model predictors of weight loss at the end of the study were sex, age and reported percentage energy from protein (R2 0·22, P < 0·05 for the whole model). Fasting plasma insulin decreased (P < 0·01, with no difference between diets), 13·9 (sd 4·6) to 10·2 (sd 5·2) mIU/l, but fasting plasma glucose was not reduced. Neither total cholesterol nor LDL-cholesterol were different but HDL was higher, 1·19 (sd 0·26) v. 1·04 (sd 0·29) (P < 0·001 for time, no diet effect), while TAG was lower, 1·87 (sd 1·23) v. 2·22 (sd 1·15) mmol/l (P < 0·05 for time, no diet effect). C-reactive protein decreased (3·97 (sd 2·84) to 2·43 (sd 2·29) mg/l, P < 0·01). Food records showed that compliance to the prescribed dietary patterns was poor. After 1 year there remained a clinically significant weight loss and improvement in cardiovascular risk factors with no adverse effects of a high monounsaturated fat diet.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Long-term weight maintenance and cardiovascular risk factors are not different following weight loss on carbohydrate-restricted diets high in either monounsaturated fat or protein in obese hyperinsulinaemic men and women
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Long-term weight maintenance and cardiovascular risk factors are not different following weight loss on carbohydrate-restricted diets high in either monounsaturated fat or protein in obese hyperinsulinaemic men and women
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Long-term weight maintenance and cardiovascular risk factors are not different following weight loss on carbohydrate-restricted diets high in either monounsaturated fat or protein in obese hyperinsulinaemic men and women
      Available formats
      ×
Copyright
Corresponding author
*Ms Jennifer Keogh, P.O. Box 10041 BC, Adelaide, SA 5000, Australia, fax +61 08 8303 8899, jennifer.keogh@csiro.au
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

A Astrup , GK Grunwald , EL Melanson , WH Saris & JO Hill (2000) The role of low-fat diets in body weight control: a meta-analysis of ad libitum dietary intervention studies. Int J Obes Relat Metab Disord 24, 15451552.

A Avenell , J Broom , TJ Brown , A Poobalan , L Aucott , SC Stearns , WC Smith , RT Jung , MK Campbell & AM Grant (2004) Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement. Health Technol Assess 8, 1182.

WE Boden (2000) High-density lipoprotein cholesterol as an independent risk factor in cardiovascular disease: assessing the data from Framingham to the Veterans Affairs High-Density Lipoprotein Intervention Trial. Am J Cardiol 86, 19L22L.

GD Brinkworth , M Noakes , JB Keogh , ND Luscombe , GA Wittert & PM Clifton (2004a) Long-term effects of a high-protein, low-carbohydrate diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects. Int Obes Relat Metab Disord 28, 661670.

A Due , S Toubro , AR Skov & A Astrup (2004) Effect of normal-fat diets, either medium or high in protein, on body weight in overweight subjects: a randomised 1-year trial. Int J Obes Relat Metab Disord 28, 12831290.

GD Foster , HR Wyatt , JO Hill , BG McGuckin , C Brill , BS Mohammed , PO Szapary , DJ Rader , JS Edman & S Klein (2003) A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med 348, 20822090.

P Froom & U Goldbourt (2004) Secular decrease in blood pressure and reduction in mortality from cardiovascular disease in Israeli workers. J Hum Hypertens 18, 113118.

RJ Hill & PSW Davies (2001) The validity of self-reported energy intake as determined using the doubly labeled water technique. B J Nutr 85, 415430.

JE Hokanson & MA Austin (1996) Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk 3, 213219.

MP Lejeune , EM Kovacs & MS Westerterp-Plantenga (2005) Additional protein intake limits weight regain after weight loss in humans. Br J Nutr 93, 281289.

J Lindstrom , A Louheranta , M Mannelin , M Rastas , V Salminen , J Eriksson , M Uusitupa & J Tuomilehto (2003) Finnish Diabetes Prevention Study Group. The Finnish Diabetes Prevention Study. (DPS): lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care 26, 32303236.

AG Mainous 3rd, CJ Everett , H Liszka , DE King & BM Egan (2004) Prehypertension and mortality in a nationally representative cohort. Am J Cardiol 94, 14961500.

KA Meckling , C O'Sullivan & D Saari (2004) Comparison of a low-fat diet to a low-carbohydrate diet on weight loss, body composition, and risk factors for diabetes and cardiovascular disease in free-living, overweight men and women. J Clin Endocrinol Metab 89, 27172723.

M Miller (2000) Differentiating the effects of raising low levels of high-density lipoprotein cholesterol versus lowering normal triglycerides: further insights from the Veterans Affairs High-Density Lipoprotein Intervention Trial. Am J Cardiol 86, 23L27L.

PM Ridker , CH Hennekens , JE Buring & N Rifai (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342, 836843.

PM Ridker , PW Wilson & SM Grundy (2004) Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? Circulation 109, 28182825.

PM Ridker , CP Cannon , D Morrow , N Rifai , LM Rose , CH McCabe , MA Pfeffer & E Braunwald (2005) Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Investigators. C-reactive protein levels and outcomes after statin therapy. N Engl J Med 352, 2028.

L Stern , N Iqbal , P Seshadri , KL Chicano , DA Daily , J McGrory , M Williams , EJ Gracely & FF Samaha (2004) The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med 140, 778785.

LA Vazquez , F Pazos , JR Berrazueta , C Fernandez-Escalante , MT Garcia-Unzueta , J Freijanes & JA Amado (2005) Effects of changes in body weight and insulin resistance on inflammation and endothelial function in morbid obesity after bariatric surgery. J Clin Endocrinol Metab 90, 316322.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: