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Metabolism of heat-damaged proteins in the rat

Inhibition of amino acid uptake by ‘unavailable peptides’ isolated from enzymic digests of heat-damaged cod fillet

Published online by Cambridge University Press:  09 March 2007

C. Shorrock  and
J. E. Ford
C. Shorrock
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading RG2 9AT
J. E. Ford
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading RG2 9AT
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Abstract

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1. An extract containing ‘unavailable’ small peptides was isolated from an enzymic digest of heat-damaged cod fillet and examined for its influence on uptake of leucine in the rat small intestine, using the everted-sac technique.

2. The extract strongly inhibited the uptake of leucine. It had no effect on uptake of glucose or its metabolism to lactate.

3. The findings are discussed in relation to the concept (Buraczewski, Buraczewska & Ford, 1967) that the accumulation of ‘unavailable peptide’ material in the intestine, found in rats given heat-damaged protein, might hinder the absorption of amino acids by blocking a mechanism involved in their transport across the mucosal barrier.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 40 , Issue 2 , September 1978 , pp. 185 - 191
Copyright
Copyright © The Nutrition Society 1978

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