Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 130
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Ahtesh, Fatah Stojanovska, Lily Shah, Nagendra and Mishra, Vijay Kumar 2016. Effect of Flavourzyme®on Angiotensin-Converting Enzyme Inhibitory Peptides Formed in Skim Milk and Whey Protein Concentrate during Fermentation byLactobacillus helveticus. Journal of Food Science, Vol. 81, Issue. 1, p. M135.


    Bongard, V Arveiler, D Dallongeville, J Ruidavets, J-B Wagner, A Simon, C Marécaux, N and Ferrières, J 2016. Food groups associated with a reduced risk of 15-year all-cause death. European Journal of Clinical Nutrition, Vol. 70, Issue. 6, p. 715.


    Chim-Chi, Y. Olivera-Castillo, L. Betancur-Ancona, D. and Chel-Guerrero, L. 2016. Protein hydrolysate fractions from sea cucumber (Isostichopus badionotus) inhibit angiotensin-converting enzyme. Journal of Aquatic Food Product Technology,


    Dave, Lakshmi Hayes, Maria Mora, Leticia Montoya, Carlos Moughan, Paul and Rutherfurd, Shane 2016. Gastrointestinal Endogenous Protein-Derived Bioactive Peptides: An in Vitro Study of Their Gut Modulatory Potential. International Journal of Molecular Sciences, Vol. 17, Issue. 4, p. 482.


    Gangopadhyay, Nirupama Wynne, Kieran O’Connor, Paula Gallagher, Eimear Brunton, Nigel P. Rai, Dilip K. and Hayes, Maria 2016. In silico and in vitro analyses of the angiotensin-I converting enzyme inhibitory activity of hydrolysates generated from crude barley (Hordeum vulgare) protein concentrates. Food Chemistry, Vol. 203, p. 367.


    Hayes, Maria Mora, Leticia Hussey, Karen and Aluko, Rotimi E. 2016. Boarfish protein recovery using the pH-shift process and generation of protein hydrolysates with ACE-I and antihypertensive bioactivities in spontaneously hypertensive rats. Innovative Food Science & Emerging Technologies,


    Petrat-Melin, Bjørn Kristiansen, Gitte H. Le, Thao T. Poulsen, Nina A. Larsen, Lotte B. and Young, Jette F. 2016. In vitro gastrointestinal digestion of purified bovine kappa-casein variants A, B, and E: Effects on antioxidant and angiotensin 1-converting enzyme inhibitory capacity. International Dairy Journal, Vol. 57, p. 44.


    Santiago-López, Lourdes Hernández-Mendoza, Adrián Vallejo-Cordoba, Belinda Mata-Haro, Verónica and González-Córdova, Aarón F 2016. Food-derived immunomodulatory peptides. Journal of the Science of Food and Agriculture, Vol. 96, Issue. 11, p. 3631.


    Sharma, Ranjan 2016. Handbook of Functional Beverages and Human Health.


    Sultan, Saira Huma, Nuzhat Butt, Masood Sadiq Aleem, Muhammad and Abbas, Munawar 2016. Therapeutic potential of dairy bioactive peptides: A Contemporary Perspectives. Critical Reviews in Food Science and Nutrition, p. 00.


    Ackaah-Gyasi, Nana Akyaa Zhang, Yi and Simpson, Benjamin K. 2015. Advances in Food Biotechnology.


    Bhat, Zuhaib Fayaz Kumar, Sunil and Bhat, Hina Fayaz 2015. Antihypertensive Peptides of Animal Origin: A Review. Critical Reviews in Food Science and Nutrition, p. 00.


    Connolly, Alan O’Keeffe, Martina B. Piggott, Charles O. Nongonierma, Alice B. and FitzGerald, Richard J. 2015. Generation and identification of angiotensin converting enzyme (ACE) inhibitory peptides from a brewers’ spent grain protein isolate. Food Chemistry, Vol. 176, p. 64.


    Ikeda, Asami Ichino, Hayato Kiguchiya, Saori Chigwechokha, Petros Komatsu, Masaharu and Shiozaki, Kazuhiro 2015. Evaluation and Identification of Potent Angiotensin-I Converting Enzyme Inhibitory Peptide Derived from Dwarf Gulper Shark (Centrophorus atromarginatus). Journal of Food Processing and Preservation, Vol. 39, Issue. 2, p. 107.


    Jahan-Mihan, Alireza Rodriguez, Judith Christie, Catherine Sadeghi, Marjan and Zerbe, Tara 2015. The Role of Maternal Dietary Proteins in Development of Metabolic Syndrome in Offspring. Nutrients, Vol. 7, Issue. 11, p. 9185.


    Lollo, Pablo C.B. Morato, Priscila N. Moura, Carolina S. Almada, Carine N. Felicio, Taissa L. Esmerino, Erick A. Barros, Márcio E. Amaya-Farfan, Jaime Sant'Ana, Anderson S. Raices, Renata R.S. Silva, Márcia C. and Cruz, Adriano G. 2015. Hypertension parameters are attenuated by the continuous consumption of probiotic Minas cheese. Food Research International, Vol. 76, p. 611.


    Manzanares, Paloma Salom, Juan B. García-Tejedor, Aurora Fernández-Musoles, Ricardo Ruiz-Giménez, Pedro and Gimeno-Alcañíz, José V. 2015. Unraveling the mechanisms of action of lactoferrin-derived antihypertensive peptides: ACE inhibition and beyond. Food Funct., Vol. 6, Issue. 8, p. 2440.


    Mitsuhashi, Jun Nakayama, Tsutomu and Narai-Kanayama, Asako 2015. Mechanism of papain-catalyzed synthesis of oligo-tyrosine peptides. Enzyme and Microbial Technology, Vol. 75-76, p. 10.


    Saadi, Sami Saari, Nazamid Anwar, Farooq Abdul Hamid, Azizah and Ghazali, Hasanah Mohd 2015. Recent advances in food biopeptides: Production, biological functionalities and therapeutic applications. Biotechnology Advances, Vol. 33, Issue. 1, p. 80.


    Scavuzzi, Bruna Barreto, Fabiola and da Silva, Lucia 2015. Nutritional Intervention in Metabolic Syndrome.


    ×

Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme

  • Richard J. FitzGerald (a1) and H. Meisel (a2)
  • DOI: http://dx.doi.org/10.1017/S0007114500002221
  • Published online: 01 March 2007
Abstract

Numerous casein and whey protein-derived angiotensin-I-converting enzyme (ACE) inhibitory peptides/hydrolysates have been identified. Clinical trials in hypertensive animals and humans show that these peptides/hydrolysates can bring about a significant reduction in hypertension. These peptides/hydrolysates may be classified as functional food ingredients and nutraceuticals due to their ability to provide health benefits i.e. as functional food ingredients in reducing the risk of developing a disease and as nutraceuticals in the prevention/treatment of disease.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: R. J. FitzGerald
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

RP Ames (1983) Negative effects of diuretic drugs on metabolic risk factors for coronary heart disease. American Journal of Cardiology 51, 632638.

Y Ariyoshi (1993) Angiotensin-converting enzyme inhibitors derived from food proteins. Trends in Food Science and Technology 4, 139144.

PJ Bouchier , RJ FitzGerald and G O'Cuinn (1999) Hydrolysis of αS1- and β-casein-derived peptides with a broad specificity aminopeptidase and proline specific aminopeptidases from Latococcus lactis subsp cremoris AM2. FEBS Letters 445, 321324.

H Chiba and M Yoshikawa (1991) Bioactive peptides derived from food proteins. Kagaku to Seibutsu 29, 454458.

EG Erdos (1975) Angiotensin-I-converting enzyme. Circulation Research 36, 247255.

RJ FitzGerald and H Meisel (1999) Lactokinins: whey protein-derived ACE inhibitory peptides. Nahrung 43, 165167.

YS Kim , W Bertwhistle and YW Kim (1972) Peptide hydrolyses in the brush border and soluble fractions of small intestinal mucosa of rat and man. Journal of Clinical Investigation 51, 14191430.

S Maruyama , H Mitachi , H Tanaka , N Tomizuka and H Suzuki (1987) Studies on the active site and antihypertensive activity of angiotensin I-converting enzyme inhibitors derived from casein. Agricultural Biological Chemistry 51, 15811586.

S Maruyama , K Nakagomi , N Tomizuka and H Suzuki (1985) Angiotensin I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. II Isolation and bradykinin-potentiating activity on the uterus and the ileum of rats. Agricultural Biological Chemistry 49, 14051409.

S Maruyama and H Suzuki (1982) A peptide inhibitor of angiotensin I converting enzyme in the tryptic hydrolysate of casein. Agricultural Biological Chemistry 46, 13931394.

MM Mullally , H Meisel and RJ FitzGerald (1997) Angiotensin-I-converting enzyme inhibitory activities of gastric and pancreatic proteinase digests of whey proteins. International Dairy Journal 7, 299303.

MM Mullally , H Meisel and RJ FitzGerald (1997) Identification of a novel angiotensin-I-converting enzyme inhibitory peptide corresponding to a tryptic digest of bovine β-lactoglobulin. FEBS Letters 402, 99101.

H Nakamura (1987) Effects of antihypertensive drugs on plasma lipid. American Journal of Cardiology 60, 24E-28E.

Y Nakamura , N Yamamoto , K Sakai , A Okubo , S Yamazaki and T Takano (1995) Purification and characterization of angiotensin I-converting enzyme inhibitors from a sour milk. Journal of Dairy Science 78, 777783.

MA Ondetti and DW Cushman (1982) Enzymes of the renin–angiotensin system and their inhibitors. Annual Review of Biochemistry 51, 283308.

MA Ondetti , B Rubin and DW Cushman (1977) Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents. Science 196, 441444.

A Philanto-Leppälä , T Rokka and H Korhonen (1998) Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. International Dairy Journal 8, 325331.

S Sekiya , Y Kobayashi , E Kita , Y Imamura and S Toyama (1992) Antihypertensive effects of tryptic hydrolysate of casein on normotensive and hypertensive volunteers. Journal of the Japanese Society of Nutrition and Food Science 45, 513517.

S Seseko and Y Kaneko (1985) Cough associated with the use of captopril. Archives of Internal Medicine 145, 1524.

LT Skeegs , JE Kahn and NP Shumway (1956) The preparation and function of the angiotensin-converting enzyme. Journal of Experimental Medicine 103, 295299.

BR Steve , A Fernandez , C Kneer , JJ Cerda , MI Phillips and ER Woodward (1988) Human intestinal brush border angiotensin-converting enzyme activity and its inhibition by antihypertensive ramipril. Gastroenterology 94, 942994.

T Takano (1998) Milk derived peptides and hypertension reduction. International Dairy Journal 8, 375381.

T Unger , D Ganten , RE Lang and BA Scholkens (1985) Persistent tissue converting enzyme inhibition following chronic treatment with Hoe498 and MK421 in spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology 7, 3641.

P Velletri and BL Bean (1982) The effect of Captopril on rat aortic angiotensin-converting enzyme. Journal of Cardiovascular Pharmacology 4, 315325.

N Yamamoto , A Akino and T Takano (1994) Antihypertensive effects of peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790. Journal of Dairy Science 77, 917922.

N Yamamoto , M Maeno and T Takano (1999) Purification and characterisation of an antihypertensive peptide from yoghurt-like product fermented by Lactobacillus helveticus CPN4. Journal of Diary Science 82, 13881393.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: