1 JM Vaquerizas , SK Kummerfeld , SA Teichmann , et al. (2009) A census of human transcription factors: function, expression and evolution. Nat Rev 10, 252–263.
2 SE Malmberg & CM Adams (2008) Insulin signaling and the general amino acid control response. Two distinct pathways to amino acid synthesis and uptake. J Biol Chem 283, 19229–19234.
3 VC Arantes , VP Teixeira , MA Reis , et al. (2002) Expression of PDX-1 is reduced in pancreatic islets from pups of rat dams fed a low protein diet during gestation and lactation. J Nutr 132, 3030–3035.
4 GP Ravelli , ZA Stein & MW Susser (1976) Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 7, 349–353.
5 G Kaati , LO Bygren & S Edvinsson (2002) Cardiovascular and diabetes mortality determined by nutrition during parents' and grand parents' slow growth period. Eur J Hum Genet 10, 682–688.
6 RC Wek , HY Jiang & TG Anthony (2006) Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans 34, (Pt 1), 7–11.
7 MG Buse & SS Reid (1975) Leucine. A possible regulator of protein turnover in muscle. J Clin Invest 56, 1250–1261.
8 RM Fulks , JB Li & AL Goldberg (1975) Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. J Biol Chem 250, 290–298.
9 JB Li & LS Jefferson (1978) Influence of amino acid availability on protein turnover in perfused skeletal muscle. Biochimica et Biophysica Acta 544, 351–359.
10 L Hagenfeldt , S Eriksson & J Wahren (1980) Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects. Clin Sci (Lond) 59, 173–181.
11 MA McNurlan , EB Fern & PJ Garlick (1982) Failure of leucine to stimulate protein synthesis in vivo. Biochem J 204, 831–838.
12 WE Mitch , M Walser & DG Sapir (1981) Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man. J Clin Invest 67, 553–562.
13 DG Sapir & M Walser (1977) Nitrogen sparing induced early in starvation by infusion of branched-chain ketoacids. Metab: Clin Experi 26, 301–308.
14 RS Sherwin (1978) Effect of starvation on the turnover and metabolic response to leucine. J Clin Invest 61, 1471–1481.
15 JC Anthony , TG Anthony , SR Kimball , et al. (2000) Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J Nutr 130, 139–145.
16 SJ Crozier , SR Kimball , SW Emmert , et al. (2005) Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr 135, 376–382.
17 JC Anthony , F Yoshizawa , TG Anthony , et al. (2000) Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 130, 2413–2419.
18 R Murgas Torrazza , A Suryawan , MC Gazzaneo , et al. (2010) Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation. J Nutr 140, 2145–2152.
19 JC Floyd Jr, SS Fajans , S Pek , et al. (1970) Synergistic effect of certain amino acid pairs upon insulin secretion in man. Diabetes 19, 102–108.
20 PJ Garlick & I Grant (1988) Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids. Biochem J 254, 579–584.
21 JC Anthony , AK Reiter , TG Anthony , et al. (2002) Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes 51, 928–936.
22 JC Anthony , CH Lang , SJ Crozier , et al. (2002) Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. Am J Physiol 282, E1092–E1101.
23 JS Greiwe , G Kwon , ML McDaniel , et al. (2001) Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle. Am J Physiol 281, E466–E471.
24 CM Ingberg , S Sarnblad , M Palmer , et al. (2003) Body composition in adolescent girls with type 1 diabetes. Diabet Med 20, 1005–1011.
25 V Desikan , I Mileva , J Garlick , et al. (2010) The effect of oral leucine on protein metabolism in adolescents with type 1 diabetes mellitus. Int J Pediatr Endocrinol 2010, 493258.
26 IL Baptista , ML Leal , GG Artioli , et al. (2010) Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases. Muscle Nerve 41, 800–808.
27 T Sugawara , Y Ito , N Nishizawa , et al. (2009) Regulation of muscle protein degradation, not synthesis, by dietary leucine in rats fed a protein-deficient diet. Amino Acids 37, 609–616.
28 G Biolo , RY Fleming , SP Maggi , et al. (1995) Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am J Physiol 268, (1 Pt 1), E75–E84.
29 EL Glynn , CS Fry , MJ Drummond , et al. (2010) Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr 140, 1970–1976.
30 F Tremblay , M Krebs , L Dombrowski , et al. (2005) Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 54, 2674–2684.
31 F Tremblay & A Marette (2001) Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276, 38052–38060.
32 M Balage , J Dupont , I Mothe-Satney , et al. (2011) Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance. J Nutr Biochem 22, 219–226.
33 CS Katsanos , H Kobayashi , M Sheffield-Moore , et al. (2006) A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol 291, E381–E387.
34 I Rieu , M Balage , C Sornet , et al. (2006) Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia. J Physiol 575, (Pt 1), 305–315.
35 S Verhoeven , K Vanschoonbeek , LB Verdijk , et al. (2009) Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men. Am J Clin Nutr 89, 1468–1475.
36 CH Lang & RA Frost (2005) Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle. J Cell Physiol 203, 144–155.
37 CH Lang & RA Frost (2004) Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation. Am J Physiol 287, E721–E730.
38 I Rieu , C Sornet , J Grizard , et al. (2004) Glucocorticoid excess induces a prolonged leucine resistance on muscle protein synthesis in old rats. Experi Gerontol 39, 1315–1321.
39 AM Pruznak , AA Kazi , RA Frost , et al. (2008) Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle. J Nutr 138, 1887–1894.