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No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial – reply by Rogers et al.

  • Peter J. Rogers (a1), Katherine M. Appleton (a2), David Kessler (a3), Tim J. Peters (a3), David Gunnell (a4), Robert C. Hayward (a5), Susan V. Heatherley (a5), Leonie M. Christian (a5), Sarah A. McNaughton (a6) and Andy R. Ness (a7)...
Extract

We recently reported a null outcome from a study of n-3 long-chain PUFA supplementation in depressed mood(1).

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References
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1Rogers, PJ, Appleton, KM, Kessler, D, Peters, TJ, Gunnell, D, Hayward, RC, Heatherley, SV, Christian, LM, McNaughton, SA & Ness, AR (2008) No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial. Br J Nutr 99, 421431.
2Richardson, AJ (2008) n-3 Fatty acids and mood: the devil is in the detail. Br J Nutr 99, 221223.
3Appleton, KM, Rogers, PJ & Ness, AR (2008) Is there a role for n-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? Nutr Res Rev 21, (In the Press).
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18Hibbeln, JR, Nieminen, LRG, Blasbalg, TL, Riggs, JA & Lands, WEM (2006) Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity. Am J Clin Nutr 83, Suppl. 6, 1483S1493S.
19Hirashima, F, Parow, AM, Stoll, AL, Demopulos, CM, Damico, KE, Rohan, ML, Eskesen, JG, Zuo, CS, Cohen, BM & Renshaw, PF (2004) Omega-3 fatty acid treatment and T2 whole brain relaxation times in bipolar disorder. Am J Psychiatry 161, 19221924.
20Chalon, S, Delion-Vancassel, S, Blezung, C, Guilloteau, D, Leguisquet, AM, Besnard, JC & Durand, G (1998) Dietary fish oil affects monoaminergic neurotransmission and behaviour in rats. J Nutr 128, 25122519.
21Rogers, PJ (2001) A healthy body, a healthy mind: long-term impact of diet on mood and cognitive function. Proc Nutr Soc 60, 135143.
22Appleton, KM, Hayward, RC, Gunnell, D, Peters, TJ, Rogers, PJ, Kessler, D & Ness, AR (2006) Effects of n-3 long-chain polyunsaturated fatty acids on depressed mood: systematic review of published trials. Am J Clin Nutr 84, 13081316.
23Zhang, J & Li, Y (2008) No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial – comments by Zhang and Li. Br J Nutr doi: 10.1017/S0007114508975644.
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26Owen, AJ, Batterham, MJ, Probst, YC, Grenyer, BFS & Tapsell, LC (2005) Low vitamin E levels in major depression: diet or disease? Eur J Clin Nutr 59, 304306.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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