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Opioid peptides encrypted in intact milk protein sequences

Published online by Cambridge University Press:  09 March 2007

Hans Meisel*
Affiliation:
Bundesanstalt für Milchforschung, Institut für Chemie und Physik, Kiel, Germany
R. J. FitzGerald
Affiliation:
Life Science Department, University of Limerick, Limerick, Ireland
*
*Corresponding author: H Meisel, phone +49 431 609 2260, fax +49 431 609 2300, email meisel@bafm.de
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Abstract

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Opioid agonistic and antagonistic peptides which are inactive within the sequence of the precursor milk proteins can be released and thus activated by enzymatic proteolysis, for example during gastrointestinal digestion or during food processing. Activated opioid peptides are potential modulators of various regulatory processes in the body. Opioid peptides can interact with subepithelial opioid receptors or specific luminal binding sites in the intestinal tract. Furthermore, they may be absorbed and then reach endogenous opioid receptors.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2000

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