Hostname: page-component-76fb5796d-wq484 Total loading time: 0 Render date: 2024-04-26T21:56:22.964Z Has data issue: false hasContentIssue false
  • English
  • Français

Satiety and substrate mobilization after oral fat stimulation

Published online by Cambridge University Press:  08 March 2007

Astrid J. P. G. Smeets  and
Margriet S. Westerterp-Plantenga
Astrid J. P. G. Smeets*
Affiliation:
Maastricht University, Department of Human Biology, PO Box 616, 6200 MD, Maastricht, The Netherlands, and Wageningen Centre for Food Sciences, PO Box 557, 6700 AN, Wageningen, The Netherlands
Margriet S. Westerterp-Plantenga
Affiliation:
Maastricht University, Department of Human Biology, PO Box 616, 6200 MD, Maastricht, The Netherlands, and Wageningen Centre for Food Sciences, PO Box 557, 6700 AN, Wageningen, The Netherlands
*
*Corresponding author: Astrid Smeets, fax +31 3670976, email astrid.smeets@hb.unimaas.nl
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The aim of the study was to provoke cephalic and metabolic responses by oral fat stimulation with different high-fat meals in the postprandial state. A randomized parallel design was executed with three groups of subjects (twenty-six women and ten men; twelve subjects per group). Oral fat stimulation was achieved by the modified sham feeding (MSF) technique. Five hours after a high-fat breakfast, the subjects were given one of three test meals in random order: a high-fat lunch, water or the same lunch as the MSF. The main fat sources in the high-fat lunch and MSF were olive oil, linoleic oil and oleic oil. For 3h after the test meal, blood samples were taken for analysis of metabolite, and visual analogue scales of appetite profile were completed. A cephalic response appeared to be achieved by MSF in that we observed a relative increase in insulin and glucose; this response lasted up until 90min, indicating possible vagal stimulation. NEFA increased significantly after MSF compared with water ingestion in the case of olive oil (p<0·0001) and linoleic oil (p<0·05), but not with oleic oil. MSF provoked a significantly higher increase in triacylglycerol and glycerol levels compared with water ingestion in the case of linoleic oil (p<0·05). Satiety was significantly increased in the eating condition and in the MSF condition (p<0·0002, all oils) compared with water ingestion. We conclude that cephalic and perhaps vagal stimulation by different fats increased the concentrations of the metabolites and stimulated satiety, with linoleic oil showing the strongest response.

Keywords

Fat perceptionCephalic responseSatiety
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 4 , April 2006 , pp. 795 - 801
Copyright
Copyright © The Nutrition Society 2006

References

Ahren, B & Holst, JJThe cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes (2001) 50 (5), 1030–1038.CrossRefGoogle ScholarPubMed
Blundell, JEHill, AJ & Rogers, PJHunger and the satiety cascade – their importance for food acceptance in the late 20th century In Food acceptability. pp. 233–250 [DMH Thompson, editor].Amsterdam: Elsevier Applied Science. (1988)Google Scholar
Drewnowski, aEnergy intake and sensory properties of food. Am J Clin Nutr (1995) 62, 1081S–1085S.CrossRefGoogle ScholarPubMed
Drewnowski, ATaste preference and food intake. Ann Rev Nutr (1997) 17, 237–253.CrossRefGoogle ScholarPubMed
Evans, K, Clark, ML & Frayn, KNEffects of an oral and intravenous fat load on adipose tissue and forearm lipid metabolism. Am J Physiol (1999) 276, E241–E248.Google ScholarPubMed
Evans, K, Kuusela, PJ, Cruz, ML, Wilhelmova, I, Fielding, BA & Frayn, KNRapid chylomicron appearance following sequential meals: effects of second meal composition. Br J Nutr (1998) 79, 425–429.CrossRefGoogle ScholarPubMed
Fielding, BA, Callow, J, Owen, RM, Samra, JS, Matthews, DR & Frayn, KNPostprandial lipemia: the origin of an early peak studied by specific dietary fatty acid intake during sequential meals. Am J Clin Nutr (1996) 63, 36–41.CrossRefGoogle ScholarPubMed
Gilbertson, TA, Fontenot, DT, Liu, L, Zhang, H & Monroe, WTFatty acid modulation of K + channels in taste receptor cells: gustatory cues for dietary fat. Am J Physiol (1997) 272, C1203–C1210.CrossRefGoogle ScholarPubMed
Heath, RB, Jones, R, Frayn, KN & Robertson, MDVagal stimulation exaggerates the inhibitory ghrelin response to oral fat in humans. J Endocrinol (2004) 180, 273–281.CrossRefGoogle ScholarPubMed
Hopman, WP, Jansen, JB, Rosenbusch, G & Lamers, CBCephalic stimulation of gallbladder contraction in humans: role of cholecystokinin and the cholinergic system. Digestion (1987) 38, 197–203.CrossRefGoogle ScholarPubMed
Jackson, KG, Robertson, MD, Deane, LO, Fielding, BA, Frayn, KN & Williams, CMThe effect of modified sham-feeding meals of varying fat content on postprandial triacylglycerol, insulin and glucose response. Proc Nutr Soc (2000) 59, 14A.Google Scholar
Jackson, KG, Robertson, MD, Fielding, BA, Frayn, KN & Williams, CMSecond meal effects: modified sham feeding does not provoke the release of stored triacylglycerol from a previous highfat meal. Br J Nutr (2001) 85, 149–156.CrossRefGoogle Scholar
Jackson, KG, Robertson, MD, Fielding, BA, Frayn, KN & Williams, CMOlive oil increases of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second meal is fed. Am J Clin Nutr (2002) 76, 942–949.CrossRefGoogle Scholar
James, PT, Rigby, N & Leach, RThe obesity epidemic, metabolic syndrome and future prevention strategies. Eur J Cardiovasc Prev Rehabil (2004) 11, 3–8.CrossRefGoogle ScholarPubMed
Kamphuis, MM, Saris, WH & Westerterp-Plantenga, MSThe effect of addition of linoleic acid on food intake regulation in linoleic acid tasters and linoleic acid non-tasters. Br J Nutr (2003) 90, 199–206.CrossRefGoogle ScholarPubMed
Kelley, DESkeletal muscle triglycerides: an aspect of regional adiposity and insulin resistance. Ann N Y Acad Sci (2002) 967, 135–145.CrossRefGoogle ScholarPubMed
Kelley, DE, Goodpaster, B, Wing, RR & Simoneau, JASkeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol (1999) 277, E1130–E1141.Google ScholarPubMed
Kissebah, AH, Alfarsi, S, Adams, PW & Wynn, VRole of insulin resistance in adipose tissue and liver in the pathogenesis of endogenous hypertriglyceridaemia in man. Diabetologia (1976) 12, 563–571.CrossRefGoogle ScholarPubMed
Kohrt, WM, Kirwan, JP, Staten, MA, Bourey, RE, King, DS & Holloszy, JOInsulin resistance in aging is related to abdominal obesity. Diabetes (1993) 42, 273–281.CrossRefGoogle ScholarPubMed
Konturek, SJ, Pepera, J, Zabielski, K, Konturek, PC, Pawlik, T, Szlachcic, A & Hahn, EGBrain-gut axis in pancreatic secretion and appetite control. J Physiol Pharmacol (2003) 54, 293–317..Google ScholarPubMed
Mattes, RDOral fat exposure alters postprandial lipid metabolism in humans. Am J Clin Nutr (1996) 63, 911–917.Google ScholarPubMed
Mattes, RDOral exposure to butter, but not fat replacers elevates postprandial triacylglycerol concentration in humans. J Nutr (2001)a 131, 1491–1496.CrossRefGoogle Scholar
Mattes, RDThe taste of fat elevates postprandial triacylglycerol. Physiol Behav (2001 b) 74, 343–348.CrossRefGoogle ScholarPubMed
Mattes, RDOral fat exposure increases the first phase triacylglycerol concentration due to release of stored lipid in humans. J Nutr (2002) 132, 3656–3662.CrossRefGoogle ScholarPubMed
Naim, M, Kare, MR & Merrie, AMEffects of oral stimulation on the cephalic phase of pancreatic exocrine in dogs. Physiol Behav (1978) 20, 563–570.CrossRefGoogle ScholarPubMed
Peel, AS, Zampelas, A, Williams, CM & Gould, BJA novel antiserum specific to apolipoprotein B-48: application in the investigation of postprandial lipidaemia in humans. Clin Sci (Lond) (1993) 85, 521–524.CrossRefGoogle ScholarPubMed
Perea, A, Clemente, F, Martinell, J, Villanueva-Penacarrillo, ML & Valverde, IPhysiological effect of glucagon in human isolated adipocytes. Horm Metab (1995) 27, 372–375.CrossRefGoogle ScholarPubMed
Rasmussen, H, Zawalich, KC, Ganesan, S, Calle, R & Zawalich, WSPhysiology and pathophysiology of insulin secretion. Diabetes Care (1990) 13, 655–666.CrossRefGoogle ScholarPubMed
Robertson, MD, Jackson, KG, Fielding, BA, Williams, CM & Frayn, KNModified sham feeding of a modest-fat meal suppresses plasma non-esterified fatty acids. Proc Nutr Soc (1999) 59, 123A.Google Scholar
Robertson, MD, Jackson, KG, Williams, CM, Fielding, BA & Frayn, KNProlonged effects of modified sham feeding on energy substrate mobilization. Am J Clin Nutr (2001) 73, 111–117.CrossRefGoogle ScholarPubMed
Robertson, MD, Mason, AO & Frayn, KNOro-sensory stimulation prior to fat ingestion impairs postprandial fat tolerance. Int J Obesity (2000) 24, S55.Google Scholar
Robertson, MD, Mason, AO & Frayn, KNTiming of vagal stimulation affects postprandial lipid metabolism in humans. Am J Clin Nutr (2002) 76, 71–77.CrossRefGoogle ScholarPubMed
Rolls, ET, Critchley, HD, Browning, AS, Hernadi, I & Lenard, LResponses to the sensory properties of fat of neurons in the primate orbitofrontal cortex. J Neurosci (1999) 19, 1532–1540.CrossRefGoogle Scholar
Schemmel, R, Mickelsen, O & Gill, JLDietary obesity in rats: body weight and body fat accretion in seven strains of rats. J Nutr (1970) 100, 1041–1048.CrossRefGoogle ScholarPubMed
Strubbe, JHParasympathetic involvement in rapid meal-associated conditioned insulin secretion in the rat. Am J Physiol (1992) 263, R615–R618.Google ScholarPubMed
Stunkard, AJ & Messick, SThe three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res (1985) 29, 71–83.CrossRefGoogle ScholarPubMed
Tittelbach, TJ & Mattes, RDOral stimulation influences postprandial triacylglycerol concentrations in humans: nutrient specificity. J Am Coll Nutr (2001) 20, 485–493.CrossRefGoogle ScholarPubMed
Tittelbach, TJ & Mattes, RDEffect of orosensory stimulation on postprandial thermogenesis in humans. Physiol Behav (2002) 75, 71–81.CrossRefGoogle ScholarPubMed
Vessby, B, Tengblad, S & Lithell, HInsulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men. Diabetologia (1994) 37, 1044–1050.CrossRefGoogle Scholar
Woods, SCGastrointestinal satiety signals. I: An overview of gastrointestinal signals that influence food intake. Am J Physiol Gastrointest Liver Physiol (2004) 286, G7–G13.CrossRefGoogle ScholarPubMed