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Testosterone, sex hormone-binding globulin, calculated free testosterone, and oestradiol in male vegans and omnivores

Published online by Cambridge University Press:  09 March 2007

Timothy J. A. Key ,
Liane Roe ,
Margaret Thorogood ,
John W. Moore ,
Graham M. G. Clark  and
Dennis Y. Wang
Timothy J. A. Key
Affiliation:
Cancer Epidemiology Unit, Imperial Cancer Research Fund, Gibson Building, Radcliffe Infirmary, Oxford OX2 6HE
Liane Roe
Affiliation:
General Practice Research Group, Imperial Cancer Research Fund, Department of Community Medicine & General Practice, Gibson Building, Radcliffe Infirmary, Oxford OX2 6HE
Margaret Thorogood
Affiliation:
General Practice Research Group, Imperial Cancer Research Fund, Department of Community Medicine & General Practice, Gibson Building, Radcliffe Infirmary, Oxford OX2 6HE
John W. Moore
Affiliation:
Clinical Endocrinology Laboratory, Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London WC2A 3PX
Graham M. G. Clark
Affiliation:
Clinical Endocrinology Laboratory, Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London WC2A 3PX
Dennis Y. Wang
Affiliation:
Clinical Endocrinology Laboratory, Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London WC2A 3PX
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Abstract

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Total testosterone (T), total oestradiol (E2) and sex hormone-binding globulin (SHBG) concentrations were measured in plasma samples from fifty-one male vegans and fifty-seven omnivores of similar age. Free T concentration was estimated by calculation, in comparison with the omnivores, the vegans had 7% higher total T (P = 0.250), 23% higher SHBG (P = 0.001), 3% lower free T (P = 0.580), and 11% higher E2 (P = 0.194). In a subset of eighteen vegans and twenty-two omnivores for whom 4 d diet records were available, there were statistically significant correlations between T and polyunsaturated fatty acids (r 0.37), SHBG and fat (r 0.43 for total fat, 0.46 for saturated fatty acids and 0.33 for polyunsaturated fatty acids), and SHBG and alcohol (r–0.39). It is concluded that a vegan diet causes a substantial increase in SHBG but has little effect on total or free T or on E2.

Keywords

Sex hormonesVegansFatAlcohol

Information

Type
Hormones and Metabolism
Information
British Journal of Nutrition , Volume 64 , Issue 1 , July 1990 , pp. 111 - 119
Copyright
Copyright © The Nutrition Society 1990

References

Abdulla, M., Andersson, I., Asp, N.-G., Berthelsen, K., Birkhed, D., Dencker, I., Johansson, C.-G., Jagerstad, M., Kolar, K., Nair, B. M., Nilsson-Ehle, P., Norden, A., Rassner, S., Akesson, B. & Ockerman, P.-A. (1981). Nutrient intake and health status of vegans. Chemical analyses of diets using the duplicate portion sampling technique. American Journal of Clinical Nutrition 34, 2464–2477.CrossRefGoogle ScholarPubMed
Adlercreutz, H., Hockerstedt, K., Bannwart, C., Bloigu, S., Hamalainen, E., Fotsis, T. & Ollus, A. (1987). Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). Journal of Steroid Biochemistry 27, 1135–1144.CrossRefGoogle ScholarPubMed
Anderson, D. C. (1974). Sex-hormone-binding globulin. Clinical Endocrinology 3, 69–96.CrossRefGoogle ScholarPubMed
Barrett-Connor, E. & Khaw, K.-T. (1987). Cigarette smoking and increased endogenous estrogen levels in men. American Journal of Epidemiology 126, 187–192.CrossRefGoogle ScholarPubMed
Belanger, A., Locong, A., Noel, C., Cusan, L., Dupont, A., Prevost, J., Caron, S. & Sevigny, J. (1989). Influence of diet on plasma steroid and sex plasma binding globulin levels in adult men. Journal of Steroid Biochemistry 32, 829–833.CrossRefGoogle ScholarPubMed
Bishop, D. T., Meikle, A. W., Slattery, M. L., Stringham, J. D., Ford, M. H. & West, D. W. (1988). The effect of nutritional factors on sex hormone levels in male twins. Genetic Epidemiology 5, 43–59.CrossRefGoogle ScholarPubMed
Carter, G. D., Holland, S. M., Alaghband-Zadeh, J., Rayman, G., Dorrington-Ward, P. & Wise, P. H. (1983). Investigation of hirsutism: testosterone is not enough. Annals of Clinical Biochemistry 20, 262–263.CrossRefGoogle ScholarPubMed
Dai, W. S., Kuller, L. H., LaPorte, R. E., Gutai, J. P., Falvo-Gerard, L. & Caggiula, A. (1981). The epidemiology of plasma testosterone levels in middle-aged men. American Journal of Epidemiology 114, 804–816.CrossRefGoogle ScholarPubMed
Deslypere, J. P. & Vermeulen, A. (1984). Leydig cell function in normal men: effect of age, life-style, residence, diet, and activity. Journal of Clinical Endocrinology and Metabolism 59, 955–962.CrossRefGoogle ScholarPubMed
Dunn, J. F., Nisula, B. C. & Rodbard, D. (1981). Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. Journal of Clinical Endocrinology and Metabolism 53, 58–68.CrossRefGoogle ScholarPubMed
Goldin, B. R., Adlercreutz, H., Gorbach, S. L., Warram, J. H., Dwyer, J. T., Swenson, L. & Woods, M. N. (1982). Estrogen excretion patterns and plasma levels in vegetarian and omnivorous women. New England Journal of Medicine 307, 1542–1547.CrossRefGoogle ScholarPubMed
Hamalainen, E., Adlercreutz, H., Puska, P. & Pietinen, P. (1984). Diet and serum sex hormones in healthy men. Journal of Steroid Biochemistry 20, 459–464.CrossRefGoogle ScholarPubMed
Heller, R. F., Wheeler, M. J., Micallef, J., Miller, N. E. & Lewis, B. (1983). Relationship of high density lipoprotein cholesterol with total and free testosterone and sex hormone binding globulin. Acta Endocrinologica 104, 253–256.Google ScholarPubMed
Henderson, B. E., Ross, R. K., Pike, M. C. & Casagrande, J. T. (1982). Endogenous hormones as a major factor in human cancer. Cancer Research 42, 3232–3239.Google Scholar
Hill, P. B. & Wynder, E. L. (1979). Effect of a vegetarian diet and dexamethasone on plasma prolactin, testosterone and dehydroepiandrosterone in men and women. Cancer Letters 7, 273–282.CrossRefGoogle ScholarPubMed
Hill, P., Wynder, E., Garbaczewski, L., Garnes, H., Walker, A. R. P. & Helman, P. (1980). Plasma hormones and lipids in men at different risk for coronary heart disease. American Journal of Clinical Nutrition 33, 1010–1018.CrossRefGoogle ScholarPubMed
Howie, B. J. & Shultz, T. D. (1985). Dietary and hormonal interrelationships among vegetarian Seventh-Day Adventists and nonvegetarian men. American Journal of Clinical Nutrition 42, 127–134.CrossRefGoogle ScholarPubMed
Kley, H. K., Solbach, H. G., McKinnan, J. C. & Kruskemper, H. L. (1979). Testosterone decrease and oestrogen increase in male patients with obesity. Acta Endocrinologica 91, 553–563.Google ScholarPubMed
Lindholm, J., Winkel, P., Brodthagen, U. & Gyntelberg, F. (1982). Coronary risk factors and plasma sex hormones. American Journal of Medicine 73, 648–651.CrossRefGoogle ScholarPubMed
Lockie, A. H., Carlson, E., Kipps, M. & Thomson, J. (1985). Comparison of four types of diet using clinical, laboratory and psychological studies. Journal of the Royal College of General Practitioners 35, 333–336.Google ScholarPubMed
Mendel, C. M., Murai, J. T., Siiteri, P. K., Monroe, S. E. & Inoue, M. (1989) Conservation of free but not total or non-sex hormone-binding-globulin-bound testosterone in serum from Nagase analbuminemic rats, Endocrinology 124, 3128–3130.CrossRefGoogle ScholarPubMed
Moore, J. W. & Bulbrook, R. D. (1988). The epidemiology and function of sex hormone-binding globulin. In Oxford Reviews of Reproductive Biology, vol. 10, pp. 180–236 [Clarke, J., editor]. Oxford: Oxford University Press.Google Scholar
Nanjee, M. N. & Wheeler, M. J. (1985) Plasma free testosterone - is an index sufficient? Annals of Clinical Biochemistry 22, 387–390.CrossRefGoogle ScholarPubMed
Paul, A. A. & Southgate, D. A. T. (1978). McCance and Widdowson's The Composition of Foods, 4th ed. London: H.M. Stationery Office.Google Scholar
Paul, A. A., Southgate, D. A. T. & Russell, J. (1980). First Supplement to McCance and Widdowson's The Composition of Foods. London: H.M. Stationery Office.Google Scholar
Rose, D. P. (1986). The biochemical epidemiology of prostatic carcinoma. Progress in Clinical and Biological Research 222, 43–68.Google ScholarPubMed
Rosenthal, M. B., Barnard, R. J., Rose, D. P., Inkeles, S., Hall, J. & Pritikin, N. (1985). Effects of a high-complex-carbohydrate, low-fat, low-cholesterol diet on levels of serum lipids and estradiol. American Journal of Medicine 78, 23–27.CrossRefGoogle ScholarPubMed
Ruutiainen, K., Sannikka, E., Santti, R., Erkkola, R. & Adlercreutz, H. (1987). Salivary testosterone in hirsutism: correlations with serum testosterone and the degree of hair growth. Journal of Clinical Endocrinology and Metabolism 64, 1015–1020.CrossRefGoogle ScholarPubMed
Sanders, T. A. B. & Key, T. J. A. (1987). Blood pressure, plasma renin activity and aldosterone concentrations in vegans and omnivore controls. Human Nutrition: Applied Nutrition 41A, 204–211.Google Scholar
Sparrow, D., Bosse, R. & Rowe, J. W. (1980). The influence of age, alcohol consumption, and body build on gonadal function in men. Journal of Clinical Endocrinology and Metabolism 51, 508–512.CrossRefGoogle ScholarPubMed
Stefanick, M. L., Williams, P. T., Krauss, R. M., Terry, R. B., Vranizan, K. M. & Wood, P. D. (1987). Relationships of plasma estradiol, testosterone, and sex hormone-binding globulin with lipoproteins, apolipoproteins, and high density lipoprotein subtractions in men. Journal of Clinical Endocrinology and Metabolism 64, 723–729.CrossRefGoogle Scholar
Tan, S. P., Wenlock, R. W. & Buss, D. H. (1985). Immigrant foods. Second Supplement to McCance and Widdowson's The Composition of Foods. London: H.M. Stationery Office.Google Scholar
Thorogood, M., Carter, R., Benfield, L., McPherson, K. & Mann, J. I. (1987). Plasma lipids and lipoprotein cholesterol concentrations in people with different diets in Britain. British Medical Journal 295, 351–353.CrossRefGoogle ScholarPubMed
Wharton, P. A. & Eaton, P. M. (1983). Sorrento Asian food tables: food tables, recipes and customs of mothers attending Sorrento Maternity Hospital, Birmingham, England. Human Nutrition: Applied Nutrition 37A, 378–402.Google Scholar
Wiles, S. J., Nettleton, P. A., Black, A. E. & Paul, A. A. (1980). The nutrient composition of some cooked dishes eaten in Britain: a supplementary food composition table. Journal of Human Nutrition 34, 189–223.Google Scholar