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Update on the assessment of magnesium status

  • Maurice J. Arnaud (a1)

Magnesium (Mg) is the fourth most abundant mineral in the body and the most abundant intracellular divalent cation, with essential roles in many physiological functions. Consequently, the assessment of Mg status is important for the study of diseases associated with chronic deficiency. In spite of intense research activities there is still no simple, rapid, and accurate laboratory test to determine total body Mg status in humans. However, serum Mg < 0·75 mmol/l is a useful measurement for severe deficiency, and for values between 0·75 and 0·85 mmol/l a loading test can identify deficient subjects. The loading test seems to be the gold standard for Mg status, but is unsuitable in patients with disturbed kidney and intestinal functions when administered orally. There is also a need to reach a consensus on a standardized protocol in order to compare results obtained in different clinical units. Other cellular Mg measurements, such as total or ionized Mg, frequently disagree and more research and systematic evaluations are needed. Muscle Mg appears to be a good marker, but biopsies limit its usefulness, as is the case with bone Mg, the most important but heterogeneous Mg compartment. The development of new and non invasive techniques such as nuclear magnetic resonance (NMR) may provide valuable tools for routinely analysing ionized Mg in tissues. With the development of molecular genetics techniques, the recent discovery of Transient Receptor Potential Melastatin channels offers new possibilities for the sensitive and rapid evaluation of Mg status in humans.

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*Corresponding author: Maurice J. Arnaud, fax +1 404 5981968, email
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1Saris N-EL, Mervaala E, Karppanen H, Khawaja JA & Lewenstam A (2000) Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta 294, 126.
2Elin RJ (1991) Laboratory tests for the assessment of magnesium status in humans. Magnes Trace Elem 92, 172181.
3Franz KB (2004) A functional biological marker is needed for diagnosing magnesium deficiency. J Am Coll Nutr 23, 738S741S.
4Arnaud MJ (1977) Autoradiographic study in the rat of the transit of magnesium from mineral water. Acta Pharmacologica et Toxicologica 21, 154155.
5Danielson BG, Johansson G & Ljunghall S (1979) Magnesium metabolism in healthy subjects. Scand J Urol Nephrol Suppl 51, 4973.
6Avioli LV & Berman M (1966) Mg28 kinetics in man. J Appl Physiol 21, 16881694.
7Watson WS, Hilditch TE, Horton PW, Davies DL & Lindsay R (1979) Magnesium metabolism in blood and the whole body in man using 28magnesium. Metabolism 28, 9095.
8Gold SW, Riediger H, Matthes S, Kuhn D, Graef V, Temme H, Katz N & Roka L (1991) Homeostasis of magnesium in man after an oral supplementation: results of a placebo-controlled blind study. In Magnesium. A Relevant Ion, pp. 227236 [Lasserre B and Durlach J, editors]. London: John Libbey.
9Abrams SA & Ellis KJ (1998) Multicompartmental analysis of magnesium and calcium kinetics during growth: relationships with body composition. Magnes Res 11, 307313.
10Sabatier M, Pont F, Arnaud MJ & Turnlund JR (2003) A compartmental model of magnesium metabolism in healthy men based on two stable isotope tracers. Am J Physiol Regul Integr Comp Physiol 285, R656R663.
11Dewitte K, Stöckl D, Van de Velde M & Thienpont LM (2000) Evaluation of intrinsic and routine quality of serum total magnesium measurement. Clin Chim Acta 292, 5568.
12Alfrey AC, Miller NL & Butkus D (1974) Evaluation of body magnesium stores. J Lab Clin Med 84, 153162.
13Arnold A, Tovey J, Mangat P, Penny W & Jacobs S (1995) Magnesium deficiency in critically ill patients. Anaesthesia 50, 203205.
14Fiser RT, Torres A Jr, Butch AW & Valentine JL (1998) Ionized magnesium concentrations in critically ill children. Crit Care Med 26, 20482052.
15Emelyanov A, Fedoseev G & Barnes PJ (1999) Reduced intracellular magnesium concentrations in asthmatic patients. Eur Respir J 13, 3840.
16Lukaski HC & Nielsen FH (2002) Dietary magnesium depletion affects metabolic responses during submaximal exercise in postmenopausal women. J Nutr 132, 930935.
17Woodard JA, Shannon M, Lacouture PG & Woolf A (1990) Serum magnesium concentrations after repetitive magnesium cathartic administration. Am J Emerg Med 8, 297300.
18Eibl NL, Kopp H-P, Nowak HR, Schnack CJ, Hopmeier PG & Schernthaner G (1995) Hypomagnesemia in Type II diabetes: effect of a 3-month replacement therapy. Diabetes Care 18, 188192.
19Wälti MK, Zimmermann MB, Spinas GA & Hurrell RF (2003) Low plasma magnesium in type 2 diabetes. Swiss Med Wkly 133, 289292.
20Corica F, Allegra A, Ientile R & Buemi M (1997) Magnesium concentration in plasma, erythrocytes, and platelets in hypertensive and normotensive obese patients. Am J Hypertens 10, 13111313.
21Gajos G, Solarska K, Siembab L, Nessler B, Nessler J, Stepniewski M & Piwowarska W (1998) The importance of magnesium depletion in end stage heart disease and the efficacy of its acute intravenous supplementation with magnesium ascorbate. Proceedings for the XIIIth World Congress of Cardiology, Rio de Janeiro, Brazil, April 26–30, Monduzzi Editore, pp. 587–591.
22Sjögren A, Florén CH & Nilsson A (1988) Evaluation of magnesium status in Crohn's disease as assessed by intracellular analysis and intravenous magnesium infusion. Scand J Gastroenterol 23, 555561.
23Kazaks AG, Uriu-Adams JY, Albertson TE & Stern JS (2006) Multiple measures of magnesium status are comparable in mild asthma and control subjects. J Asthma 43, 783788.
24Fox CH, Ramsoomair D, Mahoney MC, Carter C, Young B & Graham R (1999) An investigation of hypomagnesemia among ambulatory urban African Americans. J Fam Pract 48, 636639.
25Bock JL, Wenz B & Gupta RK (1985) Changes in intracellular Mg adenosine triphosphate and ionized Mg2+ during blood storage: detection by 31P nuclear magnetic resonance spectroscopy. Blood 65, 15261530.
26Deuster PA, Trostmann UH, Bernier LL & Dolev E (1987) Indirect vs direct measurement of magnesium and zinc in erythrocytes. Clin Chem 33, 529532.
27Nadler JL, Malayan S, Luong H, Shaw S, Natarajan RD & Rude RK (1992) Intracellular free magnesium deficiency plays a key role in increased platelet reactivity in Type II diabetes mellitus. Diabetes Care 15, 835841.
28Gürlek A, Bayraktar M & Özaltin N (1998) Intracellular magnesium depletion relates to increased urinary magnesium loss in Type I diabetes. Horm Metab Res 30, 99102.
29Engelen W, Bouten A, De Leeuw I & De Block C (2000) Are low magnesium levels in type 1 diabetes associated with electromyographical signs of polyneuropathy? Magnes Res 13, 197203.
30Şimşek E, Karabay M & Kocabay K (2005) Assessment of magnesium status in newly diagnosed diabetic children: measurement of erythrocyte magnesium level and magnesium tolerance testing. Truk J Pediatr 47, 132137.
31Thomas J, Millot JM, Sebille S, Delabroise AM, Thomas E, Manfait M & Arnaud MJ (2000) Free and total magnesium in lymphocytes of migraine patients – effect of magnesium-rich mineral water intake. Clin Chim Acta 295, 6375.
32Cox IM, Campbell MJ & Dowson D (1991) Red blood cell magnesium and chronic fatigue syndrome. The Lancet 337, 757760.
33Malon A, Brockmann C, Fijalkowska J, Rob P & Maj-Zurawska M (2004) Ionized magnesium in erythrocytes – the best magnesium parameter to observe hypo- or hypermagnesemia. Clin Chim Acta 349, 6773.
34Darlu P, Rao DC, Henrotte JG & Lalouel JM (1982) Genetic regulation of plasma and red blood cell magnesium concentrations in man. I. Univariate and bivariate path analyses. Am J Hum Genet 34, 874887.
35Lalouel JM, Darlu P, Henrotte JG & Rao DC (1983) Genetic regulation of plasma and red blood cell magnesium concentration in man. II. Segregation analysis. Am J Hum Genet 35, 938950.
36Henrotte JG, Pla M & Dausset J (1990) HLA- and H-2-associated variations of intra- and extracellular magnesium content. Proc Natl Acad Sci U S A 87, 18941898.
37Feuillet-Coudray C, Coudray C, Wolf FI, Henrotte JG, Rayssiguier Y & Mazur A (2004) Magnesium metabolism in mice selected for high and low erythrocyte magnesium levels. Metabolism 53, 660665.
38Feuillet-Coudray C, Trzeciakiewicz A, Coudray C, Rambeau M, Chanson A, Rayssiguier Y, Opolski A, Wolf FI & Mazur A (2006) Erythrocyte magnesium fluxes in mice nutritionally and genetically low in magnesium status. Eur J Nutr 45, 171177.
39Basso LE, Ubbink JB & Delport R (2000) Erythrocyte magnesium concentration as an index of magnesium status: a perspective from a magnesium supplementation study. Clin Chim Acta 291, 18.
40Borella P, Facchinetti F, Rocchi E, Lorini R & Bargellini A (1994 a) Recommendations on the use of leukocytes to assess magnesium status. In Magnesium 1993, Chapter 8, pp. 7175 [Golf S, Dralle D and Vecchiet L, editors]. London: John Libbey Ltd.
41Borrella P, Bargellini A & Ambrosini G (1994 b) Magnesium supplementation in adults with marginal deficiency: response in blood indices, urine and saliva. Magnes Bull 16, 14.
42Ryan MP & Ryan MF (1979) Lymphocyte electrolyte alterations during magnesium deficiency in the rat. Ir J Med Sci 148, 108109.
43Ryan MP, Ryan MF & Counihan TB (1980) The effects of diuretics on lymphocyte magnesium and potassium. Acta Med Scand Suppl 647, 153161.
44Ryan MP, Ryan MF & Counihan TB (1981) The effect of diuretics on lymphocyte magnesium and potassium. Acta Med Scand Suppl 647, 153161.
45Sjögren A, Floren CH & Nilsson A (1986) Magnesium deficiency in IDDM related to level of glycosylated hemoglobin. Diabetes 35, 459463.
46Gallai V, Sarchielli P, Morucci P & Abbritti G (1994) Magnesium content of mononuclear blood cells in migraine patients. Headache 34, 160165.
47Dyckner T & Wester PO (1985) Skeletal muscle magnesium and potassium determinations: correlation with lymphocyte contents of magnesium and potassium. J Am Coll Nutr 4, 619625.
48Kisters K, Tepel M, barenbrock M, Westermann G, Rahn KH, Zidek W & Spieker C (1997) Magnesium status in normotensive and essential hypertensive patients: different cell models. Med Sci Res 25, 397398.
49Cohen L & Kitzes R (1983) Magnesium sulphate and digitalis-toxic arrhythmias. J Am Med Assoc 249, 28082810.
50Sacks GS, Brown RO, Dickerson RN, Bhattacharya S, Lee PD, Mowatt-Larssen C, Ilardi G & Kudsk KA (1997) Mononuclear blood cell magnesium content and serum magnesium concentration in critically ill hypomagnesemic patients after replacement therapy. Nutrition 13, 303308.
51Elin RJ & Hosseini JM (1985) Magnesium content of mononuclear blood cells. Clin Chem 31, 377380.
52Corica F, Ientile R, Allegra A, Romano G, Cangemi F, Di Benedetto A, Buemi M, Cucinotta D & Ceruso D (1996) Magnesium levels in plasma, erythrocyte, and platelet in hypertensive and normotensive patients with type 2 diabetes mellitus. Biol Trace Elem Res 51, 1321.
53Allegra A, Corsonello A, Buemi M, D'Angelo R, Di Benedettot A, Bonanzinga S, Cucinotta D, Ientile R & Corica F (1997) Plasma, erythrocyte and platelet magnesium levels in type 1 diabetic patients with microalbuminuria and clinical proteinuria. J Trace Elements Med Biol 11, 154157.
54Resnick LM, Gupta RK, Bhargava KK, Gruenspan H, Alderman MH & Laragh JH (1991) Cellular ions in hypertension, diabetes, and obesity. A nuclear magnetic resonance spectroscopic study. Hypertension 17, 951957.
55Rubenowitz E, Landin K & Rylander R (1994) Magnesium in drinking water and in skeletal muscle and sublingual cells. Magnes Bull 16, 8186.
56Caddell JL & Scheppner R (1978) The postmortem diagnosis of magnesium deficiency: studies in an animal model for the human infant. J Forensic Sci 23, 335344.
57Caddell JL, Heineman E & Reed GF (1984) An evaluation of the parenteral magnesium load test in weanling rats. J Nutr 114, 12601265.
58Guillard O, Mettey R, Lecron JC & Pineau A (1992) Congenital hypomagnesemia: alternative to tissue biopsies for monitoring body magnesium status. Clin Biochem 25, 463465.
59Alfrey AC & Miller NL (1973) Bone magnesium pools in uremia. J Clin Invest 52, 30193027.
60Jeppesen BB (1986) Magnesium status in patients with acute myocardial infarction: a pilot study. Magnesium 5, 95100.
61Fiaccadori E, Del Canale S, Coffrini E, Melej R, Vitali P, Guariglia A & Borghetti A (1988) Muscle and serum magnesium in pulmonary intensive care unit patients. Crit Care Med 16, 751760.
62Gustafson T, Boman K, Rosenhall L, Sandström T & Wester PO (1996) Skeletal muscle magnesium and potassium in asthmatics treated with oral beta2-agonists. Eur Respir J 9, 237240.
63Landin K, Bonevik H, Rylander R & Sandström BM (1989) Skeletal muscle magnesium and drinking water magnesium level. Magnes Bull 11, 177179.
64Ladefoged K & Hagen K (1988) Correlation between concentrations of magnesium, zinc, and potassium in plasma, erythrocytes and muscle. Clin Chim Acta 177, 157166.
65Clague JE, Edwards RHT & Jackson MJ (1992) Intravenous magnesium loading in chronic fatigue syndrome. The Lancet 340, 124125.
66Brinley FJ & Scarpa A (1975) Ionized magnesium concentration in axoplasm of dialyzed squid axons. FEBS Lett 15, 8285.
67Brinley FJ, Scarpa A & Tiffert T (1977) The concentration of ionized magnesium in barnacle muscle fibres. J Physiol 266, 545565.
68Achilles W, Scheidt B, Hoppe H & Cumme GA (1977) An ion exchange method to determine free metal concentrations, adapted for use in biological fluids: methods and determination of Mg2+. Acta Biol Med Ger 36, 1728.
69Grima JM & Brand JD (1977) Activity and interference effects in measurement of ionized calcium with ion-selective electrodes. Clin Chem 23, 20482054.
70Niemela JE, Snader BM & Elin RJ (1996) Determination of ionized magnesium in platelets and correlation with selected variables. Clin Chem 42, 744748.
71Cecco SA, Hristova EN, Rehak NN & Elin RJ (1997) Clinically important inter-method differences for physiologically abnormal ionized magnesium results. Am J Clin Pathol 108, 564569.
72Csako G, Rehak NN & Elin RJ (1997) Falsely high ionized magnesium results by ion-selective electrode method in severe hypomagnesemia. Eur J Clin Chem Biochem 35, 701709.
73Cook LA & Mimouni FB (1997) Whole blood ionized magnesium in the healthy neonate. J Am Coll Nutr 16, 181183.
74Hristova EN, Rehak NN, Cecco S, Ruddel M, Herion D, Eckardt M, Linnoila M & Elin RJ (1997) Serum ionized magnesium in chronic alcoholism: is it really decreased? Clin Chem 43, 394399.
75Huijgen HJ, Sanders R, Cecco SA, Rehak NN, Sanders GT & Elin RJ (1999) Serum ionized magnesium: comparison of results obtained with three ion-selective analyzers. Clin Chem Lab Med 37, 465470.
76Corica F, Corsonello A, Ientile R, Cucinotta D, Di Benedettoet A, Perticone F, Dominguez LJ & Barbagallo M (2006) Serum ionized magnesium levels in relation to metabolic syndrome in Type II diabetic patients. J Am Coll Nutr 25, 210215.
77Huijgen HJ, Sanders R, van Olden RW, Klous MG, Gaffar FR & Sanders GTB (1998) Intracellular and extracellular blood magnesium fractions in hemodialysis patients; is ionized fraction a measure of magnesium excess? Clin Chem 44, 639648.
78Greenway DC, Hindmarsh JT, Wang J, Khodadeen JA & Hébert PC (1996) Reference interval for whole blood ionized magnesium in a healthy population and the stability of ionized magnesium under varied laboratory conditions. Clin Biochem 29, 515520.
79Hoshino K, Ogawa K, Kitazawa R, Nakamura Y & Uehara R (1998) Ionized magnesium level in whole blood of healthy Japanese children. Acta Paediatr Jpn 40, 116121.
80Millot JM, Sebille S, Beljebbar M, Peirera M, Delabroise AM, Sabatier M, Caron J, Manfait M & Arnaud MJ (2001) Short-term effects of magnesium-rich natural mineral water intake by healthy volunteers on total and ionized magnesium concentrations in plasma and blood cells. J Trace Elem Exp Med 14, 329.
81Gupta RK, Benovic JL & Rose ZB (1978) The determination of free magnesium level in the human blood cell by 31P NMR. J Biol Chem 253, 61726176.
82Huskens K, Main M, Malloy CR & Sherry AD (1997) The determination of magnesium in human blood plasma by 31P magnetic resonance spectroscopy using a macrocyclic reported ligand. Biochim Biophys Acta 1336, 434444.
83Wary C, Brillault-Salvat C, Bloch G, Leroy-Willig A, Roumenov D, Grognet JM, Leclerc JH & Carlier PG (1999) Effect of chronic magnesium supplementation on magnesium distribution in healthy volunteers evaluated by 31P-NMRS and ion selective electrodes. Br J Clin Pharmacol 48, 655662.
84Halvorson HR, Vande Linde AMQ, Helpern JA & Welch KMA (1992) Assessment of magnesium concentratoins by 31P NMR in vivo. NMR in Biomed 5, 5358.
85Rosenstein DL, Ryschon TW, Niemela JE, Elin RJ, Balaban RS & Rubinow DR (1995) Skeletal muscle intracellular ionized magnesium measured by 31P-NMR spectroscopy across the menstrula cycle. J Am Coll Nutr 14, 486490.
86Lodi R, Montagna P, Soriani S, Iotti S, Arnaldi C, Cortelli P, Pierangeli G, Patuelli A, Zaniol P & Barbiroli B (1997) Deficit of brain and skeletal muscle bioenergetics and low brain magnesium in juvenile migraine: an in vivo 31P magnetic resonance spectroscolpy interictal study. Pediatr Res 42, 866871.
87Silver BB (2004) Development of cellular magnesium nano-analysis in treatment of clinical magnesium deficiency. J Am Coll Nutr 23, 732S737S.
88Combs DK, Goodrich RD & Meiske JC (1982) Mineral concentrations in hair as indicators of mineral status: a review. J Anim Sci 54, 391398.
89Hall RF, Sanders WL, Bell MC & Reynolds RA (1971) Effects of season and grass tetany on mineral composition of Hereford cattle hair. Am J Vet Res 32, 16131619.
90Brochart M (1975) Delay and magnitude of plasma bone responses and of stable, residual, leachable hair fractions to two different levels of K, Na, Ca, Mg, P intake in rat. Ann Rech Vet 6, 337344.
91Assarian GS & Oberleas D (1977) Effect of washing procedures on trace-element content of hair. Clin Chem 23, 17711772.
92Ng SY (1999) Hair calcium and magnesium levels in patients with Fibromyalgia: a case centre study. J Manipulative Physiol Ther 22, 586593.
93Kozielec T, Durska G, Karakiewicz B & Kędzierska E (2004) Analysis of blood and hair to investigate the magnesium status of neonates and their mothers. Magnes Res 17, 8589.
94Kozielec T, Salacka A, Radomska K, Strecker D & Durska G (2001) The influence of magnesium supplementation on magnesium and calcium concentrations in hair of children with magnesium shortage. Magnes Res 14, 3338.
95Vellar OD (1979) Composition of human nail substance. Am J Clin Nutr 23, 12721274.
96Garland M, Morris JS, Rosner BA, Stampfer MJ, Spate VL, Baskett CJ, Willett WC & Hunter DJ (1993) Toenail trace element levels as biomarkers: reproducibility over a 6-year period. Cancer Epidemiol Biomarkers Prev 2, 493497.
97Graham LA, Caesar JJ & Burgen ASV (1960) Gastrointestinal absorption and excretion of Mg28 in man. Metabolism 9, 646659.
98Ryzen E, Elbaum N, Singer FR & Rude RK (1985) Parenteral magnesium tolerance testing in the evaluation of magnesium deficiency. Magnesium 4, 137147.
99Rujner J, Socha J, Syczewska M, Wojtasik A, Kunachowicz H & Stolarczyk A (2004) Magnesium status in children and adolescents with celiac disease without malabsorption symptoms. Clin Nutr 23, 10741079.
100Hébert P, Mehta N, Wang J, Hindmarsh T, Jones G & Cardinal P (1997) Functional magnesium deficiency in critically ill patients identified using a magnesium-loading test. Crit Care Med 25, 749755.
101Manuel y Keenoy B, Moorkens G, Vertommen J, Noe M, Nève J & De Leeuw I (2000) Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. J Am Coll Nutr 19, 374382.
102Rob PM, Dick K, Bley N, Seyfert T, Brinckmann CH, Höllriegel V, Friedrich HJ, Dibbelt L & Seelig MS (1999) Can one really measure magnesium deficiency using the short-term magnesium loading test? J Intern Med 246, 373378.
103Gullestad L, Midtvedt K, Dolva LO, Norseth J & Kjekshus J (1994) The magnesium loading test: reference values in healthy subjects. Scand J Clin Lab Invest 54, 2331.
104Nielsen FH, Milne DB, Gallagher S, Johnson L & Hoverson B (2007) Moderate magnesium deprivation results in calcium retention and altered potassium and phosphorus excretion by postmenopausal women. Magnes Res 20, 1931.
105Holm CN, Jepsen JM, Sjogaard G & Hessov I (1979) A magnesium load test in the diagnosis of magnesium deficiency. Hum Nutr Clin Nutr 41C, 301306.
106Rasmussen HS, McNair P, Goransson L, Balsolv S, Larsen OG & Aurup P (1988) Magnesium deficiency in patients with ischemic heart disease with and without acute myocardial infarction uncovered by an intravenous loading test. Arch Intern Med 148, 329332.
107Goto K, Yasue H, Okumura K, Matsuyama K, Kugiyama K, Miyagi H & Hijashi T (1990) Magnesium deficiency detected by intravenous loading tests in variant angina pectoris. Am J Cardiol 65, 709712.
108Gullestad L, Nes M, Ronneberg R, Midtvedt K, Falch D & Kjekshus J (1994 a) Magnesium status in healthy free-living elderly Norvegians. J Am Coll Nutr 13, 4550.
109Mazur A, Felgines C, Feillet C, Boirie Y, Bellanger J, Beaufrère B, Gueux E, Rock E & Rayssiguier Y (1997) Parenteral magnesium loading test in the assessment of magnesium status in healthy adult French subjects. Magnesium 10, 5964.
110Rubenowitz E, Axelsson G & Rylander R (1998) Magnesium in drinking water and body magnesium status measured using an oral loading test. Scand J Clin Lab Invest 58, 423428.
111Schwartz R & Giesecke CC (1979) Mass spectrometry of a volatile Mg chelate in the measurement of stable 26Mg when used as a tracer. Clin Chim Acta 97, 18.
112Feillet-Coudray C, Coudray C, Tressol J-Cl, Pépin D, Mazur A, Abrams S & Rayssiguier Y (2002) Exchangeable magnesium pool masses in healthy women: effects of magnesium supplement. Am J Clin Nutr 75, 7278.
113Wälti MK, Walcyyk T, Wimmermann MB, Fortunato G, Weber M, Spinas GA & Hurrell RF (2006) Urinary excretion of an intravenous 26Mg dose as an indicator of marginal magnesium deficiency in adults. Eur J Clin Nutr 60, 147154.
114Resnick LM, Gupta RK & Laragh JH (1984) Intracellular free magnesium in erythrocytes of essential hypertension: relation to blood pressure and serum divalent cations. Proc Natl Acad Sci 81, 65116515.
115Fischer PWF & Giroux A (1991) An evaluation of plasma and erythrocyte magnesium concentration and the activities of alkaline phosphatase and creatine kinase as indicators of magnesium status. Clin Biochem 24, 215218.
116Petrault I, Zimowska W, Mathieu J, Bayle D, Rock E, Favier A, Rayssiguier Y & Mazur A (2002) Changes in gene expression in rat thymocytes identified by cDNA array support the occurrence of oxidative stress in early magnesium deficiency. Biochim Biophys Acta 1586, 9298.
117Feillet-Coudray C, Coudray C, Gueux E, Mazur A & Rayssiguier Y (2003) A new in vitro blood load test using a magnesium stable isotope for assessment of magnesium status. J Nutr 133, 12201223.
118Paunier L, Radde IC, Kooh SW, Conen PE & Fraser D (1968) Primary hypomagnesemia with secondary hypocalcemia in an infant. Pediatrics 41, 385402.
119Chubanov V, Waldegger S, Mederos y Schnitzler M, Vitzthum H, Sassen MC, Seyberth HW, Konrad M & Gudermann T (2004) Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes by hypomagnesemia with secondary hypocalcemia. PNAS 101, 28942899.
120Konrad M, Schlingmann KP & Gudermann T (2004) Insights into the molecular nature of magnesium homeostasis. Am J Physiol Renal Physiol 286, F599F605.
121Voets T, Nilius B, Hoefs S, van der Kemp AWCM, Droogmans G, Bindels RJM & Hoenderop JGJ (2004) TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem 279, 1925.
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