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Update on the assessment of magnesium status

  • Maurice J. Arnaud (a1)
Abstract

Magnesium (Mg) is the fourth most abundant mineral in the body and the most abundant intracellular divalent cation, with essential roles in many physiological functions. Consequently, the assessment of Mg status is important for the study of diseases associated with chronic deficiency. In spite of intense research activities there is still no simple, rapid, and accurate laboratory test to determine total body Mg status in humans. However, serum Mg < 0·75 mmol/l is a useful measurement for severe deficiency, and for values between 0·75 and 0·85 mmol/l a loading test can identify deficient subjects. The loading test seems to be the gold standard for Mg status, but is unsuitable in patients with disturbed kidney and intestinal functions when administered orally. There is also a need to reach a consensus on a standardized protocol in order to compare results obtained in different clinical units. Other cellular Mg measurements, such as total or ionized Mg, frequently disagree and more research and systematic evaluations are needed. Muscle Mg appears to be a good marker, but biopsies limit its usefulness, as is the case with bone Mg, the most important but heterogeneous Mg compartment. The development of new and non invasive techniques such as nuclear magnetic resonance (NMR) may provide valuable tools for routinely analysing ionized Mg in tissues. With the development of molecular genetics techniques, the recent discovery of Transient Receptor Potential Melastatin channels offers new possibilities for the sensitive and rapid evaluation of Mg status in humans.

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Corresponding author
*Corresponding author: Maurice J. Arnaud, fax +1 404 5981968, email maurice.arnaud@bluewin.ch
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1 N-EL Saris , E Mervaala , H Karppanen , JA Khawaja & A Lewenstam (2000) Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta 294, 126.

3 KB Franz (2004) A functional biological marker is needed for diagnosing magnesium deficiency. J Am Coll Nutr 23, 738S741S.

7 WS Watson , TE Hilditch , PW Horton , DL Davies & R Lindsay (1979) Magnesium metabolism in blood and the whole body in man using 28magnesium. Metabolism 28, 9095.

10 M Sabatier , F Pont , MJ Arnaud & JR Turnlund (2003) A compartmental model of magnesium metabolism in healthy men based on two stable isotope tracers. Am J Physiol Regul Integr Comp Physiol 285, R656R663.

11 K Dewitte , D Stöckl , M Van de Velde & LM Thienpont (2000) Evaluation of intrinsic and routine quality of serum total magnesium measurement. Clin Chim Acta 292, 5568.

13 A Arnold , J Tovey , P Mangat , W Penny & S Jacobs (1995) Magnesium deficiency in critically ill patients. Anaesthesia 50, 203205.

14 RT Fiser , A Torres Jr, AW Butch & JL Valentine (1998) Ionized magnesium concentrations in critically ill children. Crit Care Med 26, 20482052.

15 A Emelyanov , G Fedoseev & PJ Barnes (1999) Reduced intracellular magnesium concentrations in asthmatic patients. Eur Respir J 13, 3840.

17 JA Woodard , M Shannon , PG Lacouture & A Woolf (1990) Serum magnesium concentrations after repetitive magnesium cathartic administration. Am J Emerg Med 8, 297300.

18 NL Eibl , H-P Kopp , HR Nowak , CJ Schnack , PG Hopmeier & G Schernthaner (1995) Hypomagnesemia in Type II diabetes: effect of a 3-month replacement therapy. Diabetes Care 18, 188192.

22 A Sjögren , CH Florén & A Nilsson (1988) Evaluation of magnesium status in Crohn's disease as assessed by intracellular analysis and intravenous magnesium infusion. Scand J Gastroenterol 23, 555561.

23 AG Kazaks , JY Uriu-Adams , TE Albertson & JS Stern (2006) Multiple measures of magnesium status are comparable in mild asthma and control subjects. J Asthma 43, 783788.

27 JL Nadler , S Malayan , H Luong , S Shaw , RD Natarajan & RK Rude (1992) Intracellular free magnesium deficiency plays a key role in increased platelet reactivity in Type II diabetes mellitus. Diabetes Care 15, 835841.

28 A Gürlek , M Bayraktar & N Özaltin (1998) Intracellular magnesium depletion relates to increased urinary magnesium loss in Type I diabetes. Horm Metab Res 30, 99102.

31 J Thomas , JM Millot , S Sebille , AM Delabroise , E Thomas , M Manfait & MJ Arnaud (2000) Free and total magnesium in lymphocytes of migraine patients – effect of magnesium-rich mineral water intake. Clin Chim Acta 295, 6375.

32 IM Cox , MJ Campbell & D Dowson (1991) Red blood cell magnesium and chronic fatigue syndrome. The Lancet 337, 757760.

33 A Malon , C Brockmann , J Fijalkowska , P Rob & M Maj-Zurawska (2004) Ionized magnesium in erythrocytes – the best magnesium parameter to observe hypo- or hypermagnesemia. Clin Chim Acta 349, 6773.

36 JG Henrotte , M Pla & J Dausset (1990) HLA- and H-2-associated variations of intra- and extracellular magnesium content. Proc Natl Acad Sci U S A 87, 18941898.

37 C Feuillet-Coudray , C Coudray , FI Wolf , JG Henrotte , Y Rayssiguier & A Mazur (2004) Magnesium metabolism in mice selected for high and low erythrocyte magnesium levels. Metabolism 53, 660665.

38 C Feuillet-Coudray , A Trzeciakiewicz , C Coudray , M Rambeau , A Chanson , Y Rayssiguier , A Opolski , FI Wolf & A Mazur (2006) Erythrocyte magnesium fluxes in mice nutritionally and genetically low in magnesium status. Eur J Nutr 45, 171177.

39 LE Basso , JB Ubbink & R Delport (2000) Erythrocyte magnesium concentration as an index of magnesium status: a perspective from a magnesium supplementation study. Clin Chim Acta 291, 18.

45 A Sjögren , CH Floren & A Nilsson (1986) Magnesium deficiency in IDDM related to level of glycosylated hemoglobin. Diabetes 35, 459463.

46 V Gallai , P Sarchielli , P Morucci & G Abbritti (1994) Magnesium content of mononuclear blood cells in migraine patients. Headache 34, 160165.

47 T Dyckner & PO Wester (1985) Skeletal muscle magnesium and potassium determinations: correlation with lymphocyte contents of magnesium and potassium. J Am Coll Nutr 4, 619625.

49 L Cohen & R Kitzes (1983) Magnesium sulphate and digitalis-toxic arrhythmias. J Am Med Assoc 249, 28082810.

50 GS Sacks , RO Brown , RN Dickerson , S Bhattacharya , PD Lee , C Mowatt-Larssen , G Ilardi & KA Kudsk (1997) Mononuclear blood cell magnesium content and serum magnesium concentration in critically ill hypomagnesemic patients after replacement therapy. Nutrition 13, 303308.

52 F Corica , R Ientile , A Allegra , G Romano , F Cangemi , A Di Benedetto , M Buemi , D Cucinotta & D Ceruso (1996) Magnesium levels in plasma, erythrocyte, and platelet in hypertensive and normotensive patients with type 2 diabetes mellitus. Biol Trace Elem Res 51, 1321.

53 A Allegra , A Corsonello , M Buemi , R D'Angelo , A Di Benedettot , S Bonanzinga , D Cucinotta , R Ientile & F Corica (1997) Plasma, erythrocyte and platelet magnesium levels in type 1 diabetic patients with microalbuminuria and clinical proteinuria. J Trace Elements Med Biol 11, 154157.

54 LM Resnick , RK Gupta , KK Bhargava , H Gruenspan , MH Alderman & JH Laragh (1991) Cellular ions in hypertension, diabetes, and obesity. A nuclear magnetic resonance spectroscopic study. Hypertension 17, 951957.

56 JL Caddell & R Scheppner (1978) The postmortem diagnosis of magnesium deficiency: studies in an animal model for the human infant. J Forensic Sci 23, 335344.

58 O Guillard , R Mettey , JC Lecron & A Pineau (1992) Congenital hypomagnesemia: alternative to tissue biopsies for monitoring body magnesium status. Clin Biochem 25, 463465.

59 AC Alfrey & NL Miller (1973) Bone magnesium pools in uremia. J Clin Invest 52, 30193027.

61 E Fiaccadori , S Del Canale , E Coffrini , R Melej , P Vitali , A Guariglia & A Borghetti (1988) Muscle and serum magnesium in pulmonary intensive care unit patients. Crit Care Med 16, 751760.

62 T Gustafson , K Boman , L Rosenhall , T Sandström & PO Wester (1996) Skeletal muscle magnesium and potassium in asthmatics treated with oral beta2-agonists. Eur Respir J 9, 237240.

64 K Ladefoged & K Hagen (1988) Correlation between concentrations of magnesium, zinc, and potassium in plasma, erythrocytes and muscle. Clin Chim Acta 177, 157166.

65 JE Clague , RHT Edwards & MJ Jackson (1992) Intravenous magnesium loading in chronic fatigue syndrome. The Lancet 340, 124125.

67 FJ Brinley , A Scarpa & T Tiffert (1977) The concentration of ionized magnesium in barnacle muscle fibres. J Physiol 266, 545565.

71 SA Cecco , EN Hristova , NN Rehak & RJ Elin (1997) Clinically important inter-method differences for physiologically abnormal ionized magnesium results. Am J Clin Pathol 108, 564569.

73 LA Cook & FB Mimouni (1997) Whole blood ionized magnesium in the healthy neonate. J Am Coll Nutr 16, 181183.

75 HJ Huijgen , R Sanders , SA Cecco , NN Rehak , GT Sanders & RJ Elin (1999) Serum ionized magnesium: comparison of results obtained with three ion-selective analyzers. Clin Chem Lab Med 37, 465470.

76 F Corica , A Corsonello , R Ientile , D Cucinotta , A Di Benedettoet , F Perticone , LJ Dominguez & M Barbagallo (2006) Serum ionized magnesium levels in relation to metabolic syndrome in Type II diabetic patients. J Am Coll Nutr 25, 210215.

78 DC Greenway , JT Hindmarsh , J Wang , JA Khodadeen & PC Hébert (1996) Reference interval for whole blood ionized magnesium in a healthy population and the stability of ionized magnesium under varied laboratory conditions. Clin Biochem 29, 515520.

79 K Hoshino , K Ogawa , R Kitazawa , Y Nakamura & R Uehara (1998) Ionized magnesium level in whole blood of healthy Japanese children. Acta Paediatr Jpn 40, 116121.

82 K Huskens , M Main , CR Malloy & AD Sherry (1997) The determination of magnesium in human blood plasma by 31P magnetic resonance spectroscopy using a macrocyclic reported ligand. Biochim Biophys Acta 1336, 434444.

83 C Wary , C Brillault-Salvat , G Bloch , A Leroy-Willig , D Roumenov , JM Grognet , JH Leclerc & PG Carlier (1999) Effect of chronic magnesium supplementation on magnesium distribution in healthy volunteers evaluated by 31P-NMRS and ion selective electrodes. Br J Clin Pharmacol 48, 655662.

84 HR Halvorson , AMQ Vande Linde , JA Helpern & KMA Welch (1992) Assessment of magnesium concentratoins by 31P NMR in vivo. NMR in Biomed 5, 5358.

85 DL Rosenstein , TW Ryschon , JE Niemela , RJ Elin , RS Balaban & DR Rubinow (1995) Skeletal muscle intracellular ionized magnesium measured by 31P-NMR spectroscopy across the menstrula cycle. J Am Coll Nutr 14, 486490.

86 R Lodi , P Montagna , S Soriani , S Iotti , C Arnaldi , P Cortelli , G Pierangeli , A Patuelli , P Zaniol & B Barbiroli (1997) Deficit of brain and skeletal muscle bioenergetics and low brain magnesium in juvenile migraine: an in vivo31P magnetic resonance spectroscolpy interictal study. Pediatr Res 42, 866871.

87 BB Silver (2004) Development of cellular magnesium nano-analysis in treatment of clinical magnesium deficiency. J Am Coll Nutr 23, 732S737S.

92 SY Ng (1999) Hair calcium and magnesium levels in patients with Fibromyalgia: a case centre study. J Manipulative Physiol Ther 22, 586593.

99 J Rujner , J Socha , M Syczewska , A Wojtasik , H Kunachowicz & A Stolarczyk (2004) Magnesium status in children and adolescents with celiac disease without malabsorption symptoms. Clin Nutr 23, 10741079.

100 P Hébert , N Mehta , J Wang , T Hindmarsh , G Jones & P Cardinal (1997) Functional magnesium deficiency in critically ill patients identified using a magnesium-loading test. Crit Care Med 25, 749755.

101 B Manuel y Keenoy , G Moorkens , J Vertommen , M Noe , J Nève & I De Leeuw (2000) Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. J Am Coll Nutr 19, 374382.

102 PM Rob , K Dick , N Bley , T Seyfert , CH Brinckmann , V Höllriegel , HJ Friedrich , L Dibbelt & MS Seelig (1999) Can one really measure magnesium deficiency using the short-term magnesium loading test? J Intern Med 246, 373378.

103 L Gullestad , K Midtvedt , LO Dolva , J Norseth & J Kjekshus (1994) The magnesium loading test: reference values in healthy subjects. Scand J Clin Lab Invest 54, 2331.

106 HS Rasmussen , P McNair , L Goransson , S Balsolv , OG Larsen & P Aurup (1988) Magnesium deficiency in patients with ischemic heart disease with and without acute myocardial infarction uncovered by an intravenous loading test. Arch Intern Med 148, 329332.

107 K Goto , H Yasue , K Okumura , K Matsuyama , K Kugiyama , H Miyagi & T Hijashi (1990) Magnesium deficiency detected by intravenous loading tests in variant angina pectoris. Am J Cardiol 65, 709712.

108 L Gullestad , M Nes , R Ronneberg , K Midtvedt , D Falch & J Kjekshus (1994 a) Magnesium status in healthy free-living elderly Norvegians. J Am Coll Nutr 13, 4550.

110 E Rubenowitz , G Axelsson & R Rylander (1998) Magnesium in drinking water and body magnesium status measured using an oral loading test. Scand J Clin Lab Invest 58, 423428.

111 R Schwartz & CC Giesecke (1979) Mass spectrometry of a volatile Mg chelate in the measurement of stable 26Mg when used as a tracer. Clin Chim Acta 97, 18.

113 MK Wälti , T Walcyyk , MB Wimmermann , G Fortunato , M Weber , GA Spinas & RF Hurrell (2006) Urinary excretion of an intravenous 26Mg dose as an indicator of marginal magnesium deficiency in adults. Eur J Clin Nutr 60, 147154.

114 LM Resnick , RK Gupta & JH Laragh (1984) Intracellular free magnesium in erythrocytes of essential hypertension: relation to blood pressure and serum divalent cations. Proc Natl Acad Sci 81, 65116515.

115 PWF Fischer & A Giroux (1991) An evaluation of plasma and erythrocyte magnesium concentration and the activities of alkaline phosphatase and creatine kinase as indicators of magnesium status. Clin Biochem 24, 215218.

116 I Petrault , W Zimowska , J Mathieu , D Bayle , E Rock , A Favier , Y Rayssiguier & A Mazur (2002) Changes in gene expression in rat thymocytes identified by cDNA array support the occurrence of oxidative stress in early magnesium deficiency. Biochim Biophys Acta 1586, 9298.

119 V Chubanov , S Waldegger , M Mederos y Schnitzler , H Vitzthum , MC Sassen , HW Seyberth , M Konrad & T Gudermann (2004) Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes by hypomagnesemia with secondary hypocalcemia. PNAS 101, 28942899.

120 M Konrad , KP Schlingmann & T Gudermann (2004) Insights into the molecular nature of magnesium homeostasis. Am J Physiol Renal Physiol 286, F599F605.

121 T Voets , B Nilius , S Hoefs , AWCM van der Kemp , G Droogmans , RJM Bindels & JGJ Hoenderop (2004) TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem 279, 1925.

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British Journal of Nutrition
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