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Vitamin B12 and gestational diabetes mellitus: a systematic review and meta-analysis

Published online by Cambridge University Press:  02 August 2022

Xue Chen Open the ORCID record for Xue Chen [Opens in a new window] ,
Yushan Du ,
Shuangbo Xia Open the ORCID record for Shuangbo Xia [Opens in a new window] ,
Zhiwen Li  and
Jufen Liu
Xue Chen
Affiliation:
School of Public Health, Bengbu Medical College, Bengbu, Anhui Province, 233030, People’s Republic of China Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of People’s Republic of China, Beijing, People’s Republic of China Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People’s Republic of China
Yushan Du
Affiliation:
Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of People’s Republic of China, Beijing, People’s Republic of China Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People’s Republic of China
Shuangbo Xia
Affiliation:
Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of People’s Republic of China, Beijing, People’s Republic of China Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People’s Republic of China
Zhiwen Li
Affiliation:
Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of People’s Republic of China, Beijing, People’s Republic of China Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People’s Republic of China
Jufen Liu*
Affiliation:
Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of People’s Republic of China, Beijing, People’s Republic of China Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People’s Republic of China
*
* Corresponding author: Dr J. Liu, fax +86 10 82801141, email liujufen@bjmu.edu.cn
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Abstract

The relationship between vitamin B12 and gestational diabetes mellitus (GDM) remains controversial. To comprehensively evaluate the relationship between vitamin B12 and GDM, and to provide more information on GDM prevention, this study provides a systematic review and meta-analysis of vitamin B12 and GDM. As of September 22, 2021, 304 articles were searched in PubMed, Web of Science, EMBASE, and Cochrane databases, of which 15 studies met the inclusion criteria. Results presented there was no association between maternal vitamin B12 concentration during the first trimester with GDM, however, low vitamin B12 concentration in the second or third trimester of pregnancy was related to an increased risk of GDM. Compared with the non-GDM group, the vitamin B12 concentration in the GDM group was remarkably decreased (MD: –10·79; 95%CI: –21·37, –0·21), and vitamin B12 deficiency increased the risk for GDM (OR: 1·59; 95%CI: 1·10, 2·29). These effects were more significant among Asians. In addition, an increased ratio of high folate to low vitamin B12 in serum also increased the risk of GDM (OR: 1·87; 95% CI: 1·46, 2·41). These results suggest that more vitamin B12 may need to be provided during pregnancy.

Keywords

Gestational diabetes mellitusVitamin B12FolateMeta-analysis
Type
Systematic Review and Meta-Analysis
Information
British Journal of Nutrition , Volume 129 , Issue 8 , 28 April 2023 , pp. 1324 - 1331
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Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society

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