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Vitamin K status is associated with childhood bone mineral content

  • Marieke J. H. van Summeren (a1), Silvia C. C. M. van Coeverden (a2), Leon J. Schurgers (a3), Lavienja A. J. L. M. Braam (a3), Florence Noirt (a4), Cuno S. P. M. Uiterwaal (a5), Wietse Kuis (a1) and Cees Vermeer (a3)...
Abstract

In adult bone, vitamin K contributes to bone health, probably through its role as co-factor in the carboxylation of osteocalcin. In children, the significance of vitamin K in bone-mass acquisition is less well known. The objective of this longitudinal study was to determine whether biochemical indicators of vitamin K status are related to (gains in) bone mineral content (BMC) and markers of bone metabolism in peripubertal children. In 307 healthy children (mean age 11·2 years), BMC of the total body, lumbar spine and femoral neck was determined at baseline and 2 years later. Vitamin K status (ratio of undercarboxylated (ucOC) to carboxylated (cOC) fractions of osteocalcin; UCR) was also measured at both time points. Markers of bone metabolism, sex steroids, vitamin D status and growth hormones were measured at baseline only. Large variations in the levels of the UCR were found at both time-points, indicating a substantial interindividual difference in vitamin K status. Improvement of vitamin K status over 2 years (n 281 children) was associated with a marked increase in total body BMC (r − 49·1, P < 0·001). The UCR was associated with pubertal stage, markers of bone metabolism, sex hormones and vitamin D status. A better vitamin K status was associated with more pronounced increase in bone mass in healthy peripubertal children. In order to determine the significance of these findings for childhood bone health, additional paediatric studies are needed.

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Corresponding author
*Corresponding author: Dr Marieke J. H. van Summeren, fax +31 302505349, email m.j.h.vansummeren@umcutrecht.nl
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1 LA Braam , MH Knapen , P Geusens , F Brouns , K Hamulyak , MJ Gerichhausen & C Vermeer (2003) Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcif Tissue Int 73, 2126.

3 MJ Shearer (2000) Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification. Curr Opin Clin Nutr Metab Care 3, 433438.

4 R Wallin , DC Sane & SM Hutson (2002) Vitamin K 2,3-epoxide reductase and the vitamin K-dependent gamma-carboxylation system. Thromb Res 108, 221226.

5 PV Hauschka , JB Lian & PM Gallop (1975) Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue. Proc Natl Acad Sci USA 72, 39253929.

6 PA Price , JW Poser & N Raman (1976) Primary structure of the gamma-carboxyglutamic acid-containing protein from bovine bone. Proc Natl Acad Sci USA 73, 33743375.

7 Y Koshihara & K Hoshi (1997) Vitamin K2 enhances osteocalcin accumulation in the extracellular matrix of human osteoblasts in vitro. J Bone Miner Res 12, 431438.

11 P Szulc , MC Chapuy , PJ Meunier & PD Delmas (1996) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study. Bone 18, 487488.

12 P Vergnaud , P Garnero , PJ Meunier , G Breart , K Kamihagi & PD Delmas (1997) Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J Clin Endocrinol Metab 82, 719724.

14 S Cockayne , J Adamson , S Lanham-New , MJ Shearer , S Gilbody & DJ Torgerson (2006) Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 166, 12561261.

15 H Luukinen , SM Kakonen , K Pettersson , K Koski , P Laippala , T Lovgren , SL Kivela & HK Vaananen (2000) Strong prediction of fractures among older adults by the ratio of carboxylated to total serum osteocalcin. J Bone Miner Res 15, 24732478.

18 M van Summeren , L Braam , F Noirt , W Kuis & C Vermeer (2007) Pronounced elevation of undercarboxylated osteocalcin in healthy children. Pediatr Res 61, 366370.

19 SCCMv Coeverden , JC Netelenbos , CMd Ridder , JC Roos , C Popp-Snijders & HA Delemarre-van de Waal (2002) Bone metabolism markers and bone mass in healthy pubertal boys and girls. Clin Endocrinol 57, 107116.

22 SC Van Coeverden , CM De Ridder , JC Roos , MA Van't Hof , JC Netelenbos & HA Delemarre-Van de Waal (2001) Pubertal maturation characteristics and the rate of bone mass development longitudinally toward menarche. J Bone Miner Res 16, 774781.

24 MHJ Knapen , AC Nieuwenhuijzen Kruseman , RS Wouters & C Vermeer (1998) Correlation of serum osteocalcin fractions with bone mineral density in women during the first 10 years after menopause. Calcif Tissue Int 63, 375379.

25 DA Nelson & WW Koo (1999) Interpretation of absorptiometric bone mass measurements in the growing skeleton: issues and limitations. Calcif Tissue Int 65, 13.

28 W Bounds , J Skinner , BR Carruth & P Ziegler (2005) The relationship of dietary and lifestyle factors to bone mineral indexes in children. J Am Diet Assoc 105, 735741.

29 R Paredes , G Arriagada , F Cruzat , A Villagra , J Olate , K Zaidi , WA van , JB Lian , GS Stein , JL Stein & M Montecino (2004) Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. Mol Cell Biol 24, 88478861.

30 Y Sato , Y Honda , M Kaji , T Asoh , K Hosokawa , I Kondo & K Satoh (2002) Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. Bone 31, 114118.

31 DA Bailey , HA McKay , RL Mirwald , PR Crocker & RA Faulkner (1999) A six-year longitudinal study of the relationship of physical activity to bone mineral accrual in growing children: the university of Saskatchewan bone mineral accrual study. J Bone Miner Res 14, 16721679.

32 K Manias , D McCabe & N Bishop (2006) Fractures and recurrent fractures in children; varying effects of environmental factors as well as bone size and mass. Bone 39, 652657.

33 PE Fournier , R Rizzoli , DO Slosman , G Theintz & JP Bonjour (1997) Asynchrony between the rates of standing height gain and bone mass accumulation during puberty. Osteoporos Int 7, 525532.

34 RA Faulkner , KS Davison , DA Bailey , RL Mirwald & AD Baxter-Jones (2006) Size-corrected BMD decreases during peak linear growth: implications for fracture incidence during adolescence. J Bone Miner Res 21, 18641870.

35 MHJ Knapen , LJ Schurgers & C Vermeer (2007) Vitamin K(2) supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int 18, 963972.

36 P Szulc , M Arlot , MC Chapuy , F Duboeuf , PJ Meunier & PD Delmas (1994) Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women. J Bone Miner Res 9, 15911595.

37 CJ Hernandez , GS Beaupre & DR Carter (2003) A theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of osteoporosis. Osteoporos Int 14, 843847.

38 SL Hui , CW Slemenda & CC Johnston (1990) The contribution of bone loss to postmenopausal osteoporosis. Osteoporos Int 1, 3034.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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