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Yoghurt accelerates the recovery of defence mechanisms against Streptococcus pneumoniae in protein-malnourished mice

Published online by Cambridge University Press:  08 March 2007

Julio Villena ,
Silvia Racedo ,
Graciela Agüero  and
Susana Alvarez
Julio Villena
Affiliation:
Universidad Nacional de TucumánFacultad de Bioquímica, Química y Farmacia, Balcarce 747, CP 4000, San Miguel de Tucumán, TucumánArgentina
Silvia Racedo
Affiliation:
Centro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, CP 4000, San Miguel de Tucumán, TucumánArgentina
Graciela Agüero
Affiliation:
Universidad Nacional de TucumánFacultad de Bioquímica, Química y Farmacia, Balcarce 747, CP 4000, San Miguel de Tucumán, TucumánArgentina
Susana Alvarez*
Affiliation:
Universidad Nacional de TucumánFacultad de Bioquímica, Química y Farmacia, Balcarce 747, CP 4000, San Miguel de Tucumán, TucumánArgentina Centro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, CP 4000, San Miguel de Tucumán, TucumánArgentina
*
*Corresponding author: fax +54 381 4005600, email salvarez@cerela.org.ar
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Abstract

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Experiments studied the effect of yoghurt on the recovery of defence mechanisms against Streptococcus pneumoniae respiratory infection in malnourished mice. Weaned mice were malnourished with a protein-free diet (PFD) for 21d. Malnourished mice were made replete with a balanced diet (BD), yoghurt, or the BD with supplemental yoghurt (BD+Y) for 7, 14 or 21d. The normal control (NC) group was fed the BD whereas malnourished control (MC) mice consumed only the PFD. Mice were challenged with pneumococci at the end of each dietary treatment. MC mice showed increased susceptibility to pneumococcal infection. Blood leucocytes, phagocyte activity and serum and bronco-alveolar anti-pneumococcal IgG and IgA were significantly lower in the MC than in the NC group. Repletion of malnourished mice with the BD for 21d was necessary to obtain a response to infection similar to that of NC mice; however, administration of the BD+Y for 14d was enough to normalise the immune defence mechanisms. Histological examination of MC lungs showed progressive loss of alveolar architecture. Lung injuries were significantly less pronounced in NC mice. Mice treated with the BD+Y for 14d showed histological signs similar to the NC group. The present study showed that administration of yoghurt to malnourished mice induced an early recovery of the immunological parameters studied. Despite the uncertainties about the mechanisms involved and about the human relevance of the effects observed in animal models, the present study provides a strong rationale for the hypothesis that yoghurt consumption by malnourished hosts will accelerate the recovery of the immune mechanisms involved in the protection against respiratory infections

Keywords

YoghurtMalnourished miceRespiratory infectionsStreptococcus pneumoniaeProbiotics
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 3 , March 2006 , pp. 591 - 602
Copyright
Copyright © The Nutrition Society 2006

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