Published online by Cambridge University Press: 20 January 2022
1. I will remind the reader that few gene mutations are 100 percent penetrant. Most common diseases are a product of multiple genes in addition to environmental factors that may or may not be known. If someone has the 4/4 variant of APOE, they have an 80 percent risk of Alzheimer’s dementia by their late 60s. They may not alter that genetic fact about themselves, but they may re-order life plans with that knowledge.
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3. In a public health context, think how quickly we were able to identify the original COVID virus, as well as the emerging variants we are now encountering.
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