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The Effects of Intermittent Insulin Therapy on the Autonomic Neuropathy in the Streptozotocin Diabetic Rat

Published online by Cambridge University Press:  18 September 2015

George Monckton  and
Enid Pehowich
George Monckton*
Affiliation:
Department of Medicine (Neurology) University of Alberta, Edmonton, Alberta, Canada
Enid Pehowich
Affiliation:
Department of Medicine (Neurology) University of Alberta, Edmonton, Alberta, Canada
*
Neurology Unit, 9-101 Clinical Sciences Building, The University of Alberta, 11282 - 84 Avenue, Edmonton, Alberta T6G 2G3
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An ultrastructural study of the dorsal sympathetic ganglia, chain, and myenteric plexus is described in the streptozotocin diabetic rat after intermittent insulin treatment. The observations described cover the first two weeks following induction of diabetes in which insulin was administered subcutaneously twice daily. Significant regenerative changes were seen with marked axonal sprouting noted at three days. Degenerative changes were seen to be less severe than those in untreated animals. It is concluded that the improvement in the neuropathic changes with insulin treatment supports a transient primary role of the streptozotocin in causing the neuropathy — but that the subsequent improvement seems to be related to the partial control of the diabetes.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 2 , May 1982 , pp. 79 - 84
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

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