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In the province of Quebec, a population-based study of Guillain-Barré syndrome (GBS) was conducted at the time of a mass immunization campaign against meningococcal disease, in 2001.
The study population included residents aged 2 months to 20 years observed from November 1st, 2000 to December 31, 2002, representing 4 075 465 person-years of observation. GBS cases were identified in the provincial hospital database Med-Echo and medical records were reviewed.
Thirty-three incident GBS cases were identified, including 27 cases of acute inflammatory demyelinating polyradiculopathy. The overall GBS incidence rate was 0.8/100 000 person-years, higher in persons aged 1 to 4 years (2.1/100 000) than in those 5 years or more (0.6/100 000). There was a female preponderance and no significant seasonal variation. All patients survived.
Results could be used to interpret reports of adverse events associated with the introduction of new vaccines in this age-group in Canada.
Nous avons effectué une étude de population sur le syndrome de Guillain–Barré (SGB) dans la province de Québec au moment d’une campagne d’immunisation de masse contre le méningocoque en 2001.
Les résidents âgés de 2 mois à 20 ans ont été inclus dans l’étude entre le premier novembre 2000 et le 31 décembre 2002, soit 4,075,465 personnes–années d’observation. Les cas de SGB ont été identifiés dans la base de données hospitalières provincial Med–Écho et les dossiers médicaux ont été analysés.
33 nouveaux cas de SGB ont été identifiés dont 27 cas de polyradiculopathie démyélinisante inflammatoire aiguë. Le taux d’incidence global du SGB était de 0,8/100,000 personnes–années, un taux plus élevé chez les enfants de 1 à 4 ans (2,1/100,000) que chez les enfants âgés de 5 ans ou plus (0,6/100,000), avec une prédominance féminine. Aucune variation saisonnière significative n’a été observée. Tous les patients ont survécu.
Ces résultats pourraient être utilisés dans l’interprétation de rapports d’effets indésirables associés à l’introduction de nouveaux vaccins dans ce groupe d’âge au Canada.
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