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Expression of the Immediate Early Gene c-fos in Basal Ganglia: Induction by Dopaminergic Drugs

Published online by Cambridge University Press:  18 September 2015

H.A. Robertson ,
M.L. Paul ,
R. Moratalla  and
A.M. Graybiel
H.A. Robertson*
Affiliation:
Department of Pharmacology, Dalhousie University, Halifax
M.L. Paul
Affiliation:
Department of Pharmacology, Dalhousie University, Halifax
R. Moratalla
Affiliation:
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge
A.M. Graybiel
Affiliation:
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge
*
Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
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Abstract:

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Expression of the immediate early gene c-fos is increased in mammalian neurons by a number of stimuli and the usefulness of this gene as a marker of neuronal activation has been demonstrated in several systems. Directlyacting dopamine agonists of the D1-type (SKF 38393, CY 208-243) and indirectly-acting dopamine gonists (amphetamine, cocaine) all produce a rapid and transient increase in Fos protein levels in varying patterns in striatum and cerebral cortex. irectly-acting dopamine agonists only produce c-fos activation in denervated (supersensitive) striatum whereas cocaine and amphetamine activate c-fos in striatum in naive animals. Remarkably, D2 selective antagonists such as haloperidol, albeit in high doses, also activate c-fos expression. Activation of c-fos and other immediate early genes may play a part in the development of such long-term dopamine-related effects as dyskinetic movements and addiction.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S3 , August 1991 , pp. 380 - 383
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

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