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GAB Aergic Changes in 11C-Flumazenil PET in the Drug-Naïve Stiff-Person Syndrome

  • Mi-Jung Kim (a1), Young-Min Lim (a1), Jae Seung Kim (a2) and Kwang Kuk Kim (a1)
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Abstract
Copyright
Corresponding author
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88 olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Republic of Korea. email: kkkim@amc.seoul.kr
References
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1. Dalakas, MC, Li, M, Fujii, M, Jacobowitz, DM. Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodies. Neurology. 2001;57(5):780–4.
2. Perani, D, Garibotto, V, Panzacchi, A, et al. PET evidence of central GABAergic changes in stiff-person syndrome. Mov Disord. 2007;22(7):1030–3.
3. Galldiks, N, Thiel, A, Haense, C, Fink, GR, Hilker, R. 11C-flumazenil positron emission tomography demonstrates reduction of both global and local cerebral benzodiazepine receptor binding in a patient with Stiff Person Syndrome. J Neurol. 2008;255(9):1361–4.
4. Levy, LM, Levy-Reis, I, Fujii, M, Dalakas, MC. Brain gamma-aminobutyric acid changes in stiff-person syndrome. Arch Neurol. 2005;62(6):970–4.
5. Hammers, A. Flumazenil positron emission tomography and other ligands for functional imaging. Neuroimaging Clin N Am. 2004;14(3):537–51.
6. Raju, R, Rakocevic, G, Chen, Z, et al. Autoimmunity to GABAA-receptor-associated protein in stiff-person syndrome. Brain. 2006;129(Pt12):3270–6
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Canadian Journal of Neurological Sciences
  • ISSN: 0317-1671
  • EISSN: 2057-0155
  • URL: /core/journals/canadian-journal-of-neurological-sciences
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