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Gabapentin

Published online by Cambridge University Press:  18 September 2015

J. Bruni*
Affiliation:
Division of Neurology, The Wellesley Hospital and the University of Toronto, Toronto.
*
Division of Neurology, The Wellesley Hospital, 160 Wellesley Street East, Toronto, Ontario, Canada M4Y 1J3
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Abstract:

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Gabapentin is a novel antiepileptic drug that has recently been introduced in Canada. Although its mechanism of action remains to be defined gabapentin is effective in a number of seizure models which predict its efficacy in partial and tonic-clonic seizures. Clinical studies support the clinical efficacy of gabapentin as adjunctive therapy in adults with epilepsy with partial and secondarily generalized tonic-clonic seizures. Gabapentin has a favorable pharmacokinetic profile and is generally well tolerated. More clinical data are required on the role of gabapentin in children and additional monotherapy experience is required before the role of gabapentin in the overall treatment of epilepsy can be better defined.

Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1996