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HTLV-1 Associated Myelopathy in Canada

Published online by Cambridge University Press:  18 September 2015

Christopher Power ,
Brian G. Weinshenker ,
Gregory A. Dekaban ,
G.C. Ebers ,
Gordon S. Francis  and
George P.A. Rice
Christopher Power
Affiliation:
Department of Clinical Neurological Sciences, and Robarts Research Institute, University of Western Ontario, University Hospital, London and the Montreal Neurological Hospital, Montreal
Brian G. Weinshenker
Affiliation:
Department of Clinical Neurological Sciences, and Robarts Research Institute, University of Western Ontario, University Hospital, London and the Montreal Neurological Hospital, Montreal
Gregory A. Dekaban
Affiliation:
Department of Clinical Neurological Sciences, and Robarts Research Institute, University of Western Ontario, University Hospital, London and the Montreal Neurological Hospital, Montreal
G.C. Ebers
Affiliation:
Department of Clinical Neurological Sciences, and Robarts Research Institute, University of Western Ontario, University Hospital, London and the Montreal Neurological Hospital, Montreal
Gordon S. Francis
Affiliation:
Department of Clinical Neurological Sciences, and Robarts Research Institute, University of Western Ontario, University Hospital, London and the Montreal Neurological Hospital, Montreal
George P.A. Rice*
Affiliation:
Department of Clinical Neurological Sciences, and Robarts Research Institute, University of Western Ontario, University Hospital, London and the Montreal Neurological Hospital, Montreal
*
Department of Clinical Neurological Sciences, University of Western Ontario, University Hospital, 339 Windermere Rd., London, Ontario, Canada N6A 5A5
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Abstract:

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We report the clinical and laboratory findings of six Canadian patients with progressive myelopathy associated with HTLV-1 infection. The diagnosis was suspected on clinical grounds and supported by serological studies and positive gene amplification. Only five had emigrated from an area endemic for HTLV-1 infection. Tropical spastic paraparesis should be considered in all patients with myelopathy, even those without standard serological markers of HTLV-1 infection. The pathogenesis of this condition and the serological and molecular biological means by which this diagnosis can be made are reviewed.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue 3 , August 1989 , pp. 330 - 335
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

References

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