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Immunological Associations in Familial and Non-Familial Alzheimer Patients and Their Families

Published online by Cambridge University Press:  18 September 2015

M.F. Frecker ,
W.E.M. Pryse-Philli  and
H.R. Strong
M.F. Frecker*
Affiliation:
Department of Community Medicine, Faculty of Medicine, Memorial University, St. John's
W.E.M. Pryse-Philli
Affiliation:
Division of Neurology, Faculty of Medicine, Memorial University, St. John's
H.R. Strong
Affiliation:
Department of Geriatric Psychiatry, Faculty of Medicine, Memorial University, St. John's
*
Department of Community Medicine (Genetics), Faculty of Medicine, Memorial University, St. John's, Newfoundland, Canada A1B 3V6
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Abstract:

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A number of autoimmune diseases and immune-related conditions were investigated in a series of 100 Alzheimer patients and their families. The group was divided into those who had familial dementia of the Alzheimer type and non-familial dementia of the Alzheimer type. HLA DR3 was associated with the familial dementia of the Alzheimer type patients. Adult exposure to tuberculosis appeared to be a risk factor for familial dementia of the Alzheimer type patients. Autoimmune diseases clustered among the non-familial dementia of the Alzheimer type patients, and also among their relatives. Asthma and infertility were also significantly increased among non-familial dementia of the Alzheimer type relatives. The analysis showed that (1) autoimmunity may be important in the sporadic form of Alzheimer disease; (2) it may be possible to confer a decreased risk for Alzheimer disease among relatives when many autoimmune diseases occur in the family; (3) it may be important to assess environmental risk factors for Alzheimer disease separately in patients with familial and sporadic disease; and (4) the efficacy of drug therapies may be dependent on whether the patients have a familial or sporadic form of Alzheimer disease.

Résumé:

RÉSUMÉ:

Nous avons étudié certaines maladies auto-immunes et certains troubles immunitaires chez une série de 100 patients atteints de la maladie d'Alzheimer et chez leurs familles. Le groupe était divisé en démence familiale de type Alzheimer (DFTA) et démence non familiale de type Alzheimer (DNFTA). Le HLA DR3 était associé à la DFTA. Une exposition à la tuberculose à l'âge adulte semblait être un facteur de risque pour les patients avec DFTA. 11 y avait aggrégation de maladies autoimmunes chez les patients avec DNFTA ainsi que dans leurs familles. La fréquence de l'asthme et de l'infertilité étaient également augmentées significativement dans les familles DNFTA. L'analyse a montré que 1) l'auto-immunité est peut-être un facteur important dans les formes sporadiques de la maladie d'Alzheimer; 2) il peut être possible de déterminer qui a un risque plus faible d'être atteint de la maladie d'Alzheimer dans les familles des patients quand plusieurs maladies auto-immunes sont présentes dans la famille; 3) il peut être important d'évaluer séparément les facteurs de risque environnementaux pour la maladie d'Alzheimer chez les patients qui ont une maladie familiale et chez ceux dont la maladie est spo-radique; 4) l'efficacité de la thérapie médicamenteuse peut dépendre du fait que les patients ont la forme familiale ou la forme sporadique de la maladie d'Alzheimer.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 21 , Issue 2 , May 1994 , pp. 112 - 119
Copyright
Copyright © Canadian Neurological Sciences Federation 1994

References

REFERENCES

1. Ishii, T, Haga, S, Shimizu, F. Identification of components of immunoglobulins in senile plaques by means of fluorescent antibody technique. Acta Neuropathol (Beri) 1975; 32: 157–162.CrossRefGoogle ScholarPubMed
2. Eikelenboom, P, Stam, FC. Immunoglobulins and complement factors in senile plaques. Acta Neuropathol (Beri) 1982; 57: 239–242.CrossRefGoogle ScholarPubMed
3. Itagaki, S, McGeer, PL, Akiyama, H. Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer’s disease brain tissue. Neurosci Lett 1988; 91: 259–264.CrossRefGoogle ScholarPubMed
4. McGeer, PL, Akiyama, H, Itagaki, S, McGeer, EG. Immune system response in Alzheimer’s disease. Can J Neurol Sci 1989; 16: 516–527.CrossRefGoogle ScholarPubMed
5. Ikeda, T, Yamamoto, K, Takahashi, K, Kaneyuki, H, Yamada, M. Interleukin-2 receptor in peripheral blood lymphocytes of Alzheimer’s disease patients. Acta Psychiatr Scand 1991; 84: 262–265.CrossRefGoogle ScholarPubMed
6. Bias, WB, Reveille, JD, Beaty, TH, Meyers, DA, Arnett, FC. Evidence that autoimmunity in man is a Mendelian dominant trait. Am J Hum Genet 1986; 39: 584–602.Google Scholar
7. McKhann, G, Drachman, D, Folstein, M, et al. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984; 34: 939–944.CrossRefGoogle ScholarPubMed
8. Berg, L, Hughes, CP, Cohen, LA, et al. Mild senile dementia of Alzheimer type: research diagnostic criteria, recruitment, and description of a study population. J Neurol Neurosurg Psychiatry 1982; 45: 962–968.CrossRefGoogle ScholarPubMed
9. Pfeffer, RI, Afifi, AA, Chance, JM. Prevalence of Alzheimer’s disease in a retirement community. Am J Epidemiol 1987; 125: 420–436.CrossRefGoogle Scholar
10. Folstein, MF, Folstein, SE, McHugh, PR. ‘Mini-Mental State–: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189–198.CrossRefGoogle ScholarPubMed
11. Rosen, WG, Terry, RD, Fuld, PA, Katzman, R, Peck, A. Pathological verification of ischemic score in differentiation of dementias. Ann Neurol 1980; 7: 486–488.CrossRefGoogle ScholarPubMed
12. Hamilton, M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967; 6: 278–296.CrossRefGoogle ScholarPubMed
13. Blessed, G, Tomlinson, BE, Roth, M. The association between quantitative measures of dementia and of senile changes in the cerebral grey matter of elderly subjects. Br J Psychiatry 1968; 114: 797–811.CrossRefGoogle Scholar
14. Dahlquist, G, Blom, L, Tuvemo, T, et al The Swedish childhood diabetes study - results from a nine year case register and a one year case-referent study indicating that Type 1 (insulin-dependent) diabetes mellitus is associated with both Type 2 (non-insulin-dependent) diabetes mellitis and autoimmune disorders. Diabetologia 1989; 32: 2–6.CrossRefGoogle Scholar
15. Arnett, FC, Edworthy, SM, Bloch, DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315–324.CrossRefGoogle ScholarPubMed
16. Dean, AG, Dean, JA, Burton, AH, Dicker, RC. Epi Info, Version 5: a word processing, database, and statistics program for epidemiology on microcomputers. USD, Incorporated, Stone Mountain, Georgia, 1990.Google Scholar
17. Skanes, VM, Barnard, J, Farid, N, et al. Class III alleles and high-risk MHC haplotypes in type I diabetes mellitus, Graves’ disease and Hashimoto’s thyroiditis. Mol Biol Med 1986; 3: 143–157.Google ScholarPubMed
18. Heyman, A, Wilkinson, WE, Hurwitz, BJ, et al. Alzheimer’s disease: genetic aspects and associated clinical disorders. Ann Neurol 1983; 14: 507–515.CrossRefGoogle ScholarPubMed
19. Chui, HC, Teng, EL, Henderson, VW, Moy, AC. Clinical subtypes of dementia of the Alzheimer type. Neurology 1985; 35: 1544–1550.CrossRefGoogle ScholarPubMed
20. Broe, GA, Henderson, AS, Creasey, H, et al. A case-control study of Alzheimer’s disease in Australia. Neurology 1990; 40: 1698–1707.CrossRefGoogle ScholarPubMed
21. Heston, LL, Mastri, AR, Anderson, VE, White, J. Dementia of the Alzheimer type: clinical genetics, natural history, and associated conditions. Arch Gen Psychiatry 1981; 38: 1085–1090.CrossRefGoogle ScholarPubMed
22. Fitch, N, Becker, R, Heller, A. The inheritance of Alzheimer’s disease: a new interpretation. Ann Neurol 1988; 23: 14–19.CrossRefGoogle ScholarPubMed
23. Edwards, JK, Larson, EB, Hughes, JP, Kukull, WA. Are there clinical and epidemiological differences between familial and non-familial Alzheimer’s disease? J Am Geriatr Soc 1991; 39: 477–483.CrossRefGoogle ScholarPubMed
24. Méndez, MF, Underwood, KL, Zander, BA, et al. Risk factors in Alzheimer’s disease: a clinicopathologic study. Neurology 1992; 42: 770–775.Google ScholarPubMed
25. Jorm, AF. Risk factors for Alzheimer’s disease. In: Jorm, AF, ed. The Epidemiology of Alzheimer’s Disease and Related Disorders. London: Chapman and Hall, 1990: 111–150.Google Scholar
26. Van Duijn, CM, Hofman, A, Kay, DWK. Risk factors for Alzheimer’s disease: a collaborative re-analysis of case-control studies. Int J Epidemiol 1991; 20 (Suppl 2): S1-S73.Google ScholarPubMed
27. Breteler, MMB, van Duijn, CM, Chandra, V, et al. Medical history and the risk of Alzheimer’s disease: a collaborative re-analysis of case-control studies. Int J Epidemiol 1991; 20 (Suppl 2): S36-S42.Google ScholarPubMed
28. Wolf-Klein, GP, Silverstone, FA, Brod, MS, et al. Are Alzheimer patients healthier? J Am Geriatr Soc 1988; 36: 219–224.CrossRefGoogle ScholarPubMed
29. Small, GW, Rosenthal, MJ. Coexistence of Alzheimer’s disease and diabetes mellitus. J Am Geriatr Soc 1992; 40: 1075’1076.CrossRefGoogle ScholarPubMed
30. Graves, AM, White, E, Koepsell, TD, et al. A case-control study of Alzheimer’s disease. Ann Neurol 1990; 28: 766’774.CrossRefGoogle ScholarPubMed
31. Heyman, A, Wilkinson, WE, Stafford, JA, et al. Alzheimer’s disease: a study of epidemiological aspects. Ann Neurol 1984; 15: 335–341.CrossRefGoogle ScholarPubMed
32. Kokmen, E, Beard, CM, Chandra, V, et al. Clinical risk factors for Alzheimer’s disease: a population-based case-control study. Neurology 1991; 41: 1393–1397.CrossRefGoogle ScholarPubMed
33. Henschke, PJ, Bell, DA, Cape, RDT Alzheimer’s Disease and HLA. Tissue Antigens 1978; 12: 132–135.CrossRefGoogle ScholarPubMed
34. Cohen, D, Zeller, E, Eisdorfer, C, Walford, R. Alzheimer’s disease and the main histocompatibility complex (HLA system). Abstract. Gerontologist 1979; 19 (Suppl): 57.Google Scholar
35. Walford, RL, Hodge, SE. HLA distribution in Alzheimer’s disease. In: Terasaki, PI, ed. Histocompatabiiity testing. Los Angeles: UCLA School of Medicine, 1980: 727–729.Google Scholar
36. Majsky, A, Korinkova, P, Fortynova, J, Abrahamova, J, Vojtechovsky, M. Some critical remarks on the problem of HLA association with disease. Folia Haematol 1981; 108: 386–391.Google ScholarPubMed
37. Snowden, PR, Woodrow, JC, Copeland, JRM. HLA antigens in senile dementia and multiple infarct dementia. Age Ageing 1981; 10: 259–263.CrossRefGoogle ScholarPubMed
38. Reed, E, Thompson, D, Mayeaux, R, Suciu-Foca, N. HLA antigens in Alzheimer’s disease. Tissue Antigens 1983; 21: 164–167.CrossRefGoogle ScholarPubMed
39. Endo, H, Yamamoto, F, Kuzuya, F. HLA system in senile dementia of Alzheimer type and multi-infarct dementia in Japan. Arch Gerontol Geriatr 1986; 5: 51–56.CrossRefGoogle ScholarPubMed
40. Renvoize, EB, Hambling, MH, Pepper, MD, Rajah, SM. Possible association of Alzheimer’s disease with HLA-Bwl5 and cytomegalovirus infection. Lancet 1979; 1: 1238.CrossRefGoogle ScholarPubMed
41. Wilcox, CB, Caspary, EA, Behan, PO. Histocompatibility antigens in Alzheimer’s disease. Eur Neurol 1980; 19: 262–265.CrossRefGoogle ScholarPubMed
42. Reisner, E, Heyman, A, Weinberg, T, Dawson, D, Ciftan, E. Lack of association between Alzheimer’s disease and histocompatibility antigens. Tissue Antigens 1983; 21: 31–34.CrossRefGoogle ScholarPubMed
43. Whalley, LJ, Urbaniak, SJ, Darg, C, Peutherer, JF, Christie, JE. Histocompatibility antigens and antibodies to viral and other antigens in Alzheimer pre-senile dementia. Acta Psychiatr Scand 1980; 61: 1–7.CrossRefGoogle ScholarPubMed
44. Sulkava, R, Koskimies, S, Wikstrom, J, Palo, J. HLA antigens in Alzheimer’s disease. Tissue Antigens 1980; 16: 191–194.CrossRefGoogle ScholarPubMed
45. Small, GW, Matsuyama, SS. HLA-A2 as a possible marker for early-onset Alzheimer disease in men. Neurobiol Aging 1986; 7: 211–214.CrossRefGoogle ScholarPubMed
46. Payami, H, Kaye, J, Becker, W, Norman, D, Wetzsteon, P. HLA-A2. or a closely linked gene confers susceptibility to early-onset sporadic Alzheimer’s disease in men. Neurology 1991; 41: 1544–1548.CrossRefGoogle ScholarPubMed
47. White, JA, McGue, M, Heston, LL. Fertility and parental age in Alzheimer disease. J Gerontol 1986; 41: 40–43.CrossRefGoogle ScholarPubMed
48. House, E. Light at last: triumph over tuberculosis 1900–1975, Newfoundland and Labrador. John’s, St. Newfoundland: Jesperson Press, 1981.Google ScholarPubMed
49. Young, D, Lathigra, R, Hendrix, R, Sweetser, D, Young, RA. Stress proteins are immune targets in leprosy and tuberculosis. Proc Natl Acad Sci 1988; 85: 4267–4270.CrossRefGoogle ScholarPubMed
50. Crow, MK, Friedman, SM. Microbial superantigens and autoimmune disease. Bull Rheum Dis 1992; 41: 1–3.Google ScholarPubMed
51. Rogers, J, Kirby, LC, Hempelman, SR, et al. Clinical trial of indomethacin in Alzheimer’s disease. Neurology 1993; 43: 1609–1611.CrossRefGoogle ScholarPubMed
52. McGeer, PL, Rogers, J. Anti-inflammatory agents as a therapeutic approach to Alzheimer’s disease. Neurology 1992; 42: 447–449.Google ScholarPubMed