Hostname: page-component-848d4c4894-x24gv Total loading time: 0 Render date: 2024-05-01T05:14:55.029Z Has data issue: false hasContentIssue false

Interactions Between the Benzodiazepines, Methylxanthines and Adenosine

Published online by Cambridge University Press:  18 September 2015

J.W. Phillis*
Affiliation:
Department of Physiology, College of Medicine, University of Saskatchewan
P.H. Wu
Affiliation:
Department of Physiology, College of Medicine, University of Saskatchewan
*
Department of Physiology, University of Saskatchewan, Saskatoon, Canada S7N 0W0
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Experimental evidence is cited in support of the proposal that benzodiazepines exert their anxiolytic effects by inhibiting the uptake of adenosine by central neurons and glia.

Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

REFERENCES

Assumpcâo, J.A., Bernardi, N., Brown, J. and Stone, T.W. (1979). Selective antagonism by benzodiazepines of neuronal responses to excitatory amino acids in the cerebral cortex. Br. J. Pharmac. 67, 563568.CrossRefGoogle ScholarPubMed
Bender, A.S., Phillis, J.W., and Wu, P.H. (1980). Diazepam and nitrazepam inhibit adenosine uptake by rat brain synapto-somes. J. Pharm. Pharmac. 32, 293294.CrossRefGoogle Scholar
Braestrup, C, and Squires, R.F. (1978). Brain specific benzodizepine receptors. Brit. J. Psychiat. 133, 249260.CrossRefGoogle Scholar
Davies, L.P., Cook, A.F., Poonian, , and Taylor, K.M. (1980). Displacement of (3H) diazepam binding in rat brain by dipyridamole and by 1-methylisoguanosine, a marine natural product with muscle relaxant activity. Life Sci. 26, 10981095.CrossRefGoogle ScholarPubMed
Duka, T., Hòllt, V., and Herz, A., (1979). In vivo receptor occupation by benzodiazepines and correlation with the pharmacological effect. Brain Res. 179, 147156.CrossRefGoogle ScholarPubMed
Henn, F.A., and Henke, D.J. (1978). Cellular localization of (3H) diazepam receptors. Neuropharmacology 17, 985988.CrossRefGoogle ScholarPubMed
Klepner, C.A., Lippa, A.S., Benson, D.I., Sano, M.C., and Beer, B. (1979). Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors. Pharmac. Biochem. Behav. 11, 457462.CrossRefGoogle ScholarPubMed
Mah, H.D., and Daly, J.W. (1976). Adenosine-depedent formation of cyclic AMP in brain slices. Pharm. Res. Commun. 8, 6579.CrossRefGoogle ScholarPubMed
Marangos, P.J., Paul, S.M., Parma, A.M., Goodwin, F.K., Syapin, P., and Skolnick, P. (1979). Purinergic inhibition of diazepam binding to rat brain (in vitro). Life Sci. 24, 851858.CrossRefGoogle ScholarPubMed
Möhler, H., and Okada, T. (1978). The benzodiazepine receptor in normal and pathological human brain. Br. J. Psychiat. 133, 261268.CrossRefGoogle ScholarPubMed
Phillis, J.W. (1979). Diazepam potentiation of purinergic depression of central neurons. Can. J. Physiol. Pharmacol. 57, 432435.CrossRefGoogle ScholarPubMed
Phillis, J.W., Edstrom, J.P., Kosto-Poulos, G.K., and Kirkpatrick, J.R. (1979a). Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex. Can. J. Physiol Pharmacol. 57, 12891312.CrossRefGoogle ScholarPubMed
Phillis, J.W., Edstrom, J.P., Ellis, S.W., and Kirkpatrick, J.R. (1979b). Theophylline antagonizes fiurazepam-induced depression of cerebral cortical neurons. Can. J. Physiol. Pharmacol. 57, 917920.CrossRefGoogle ScholarPubMed
Phillis, J.W., Kostopoulos, G.K., and Limacher, J.J. (1974). Depression of corticospinal cells by various purines and pyrimidines. Can. J. Physiol. Pharmacol. 52, 12261229.CrossRefGoogle ScholarPubMed
Phillis, J.W., Bender, A.S., and Wu, P.H. (1980a). Benzodiazepines inhibit adenosine uptake into rat brain synaptosomes. Brain Res. in press.CrossRefGoogle ScholarPubMed
Phillis, J.W., Siemens, R.K., and Wu, P.H. (1980b). The effect of diazepam on adenosine and acetylcholine release from rat cerebral cortex: Further evidence for a purinergic mechanism in diazepam’s action. Br. J. Pharmac. in press.CrossRefGoogle Scholar
Sulakhe, P.V., and Phillis, J.W. (1975). The release of (3H)adenosine and its derivatives from cat sensorimotor cortex. Life Sci. 17, 551556.CrossRefGoogle ScholarPubMed
Tallman, J.F., Paul, S.M., Skolnick, P., and Gallager, D.W. (1980). Receptors for the age of anxiety: Pharmacology of the benzodiazepines. Science 207, 274281.CrossRefGoogle ScholarPubMed
Traversa, U., and Newman, M. (1979). Stereospecific influence of oxazepam hemi-succinate on cyclic AMP accumulation elicited by adenosine in cerebral cortical slices. Biochem. Pharmacol. 28, 23632365.CrossRefGoogle Scholar