Hostname: page-component-76fb5796d-wq484 Total loading time: 0 Render date: 2024-04-30T01:23:55.814Z Has data issue: false hasContentIssue false
  • English
  • Français

Molecular Genetics of Familial Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

P.H. George-Hyslop ,
J.L. Haines ,
R.J. Polinsky ,
R.E. Tanzi ,
L. Farrer ,
R.H. Myers  and
J.F. Gusella
P.H. George-Hyslop*
Affiliation:
Molecular Neurogenetics Laboratory, Research 3, Massachusetts General Hospital, Boston
J.L. Haines
Affiliation:
Molecular Neurogenetics Laboratory, Research 3, Massachusetts General Hospital, Boston
R.J. Polinsky
Affiliation:
Neuropharmacology Division, Medical Neurology Branch, NINCDS, Bethesda
R.E. Tanzi
Affiliation:
Molecular Neurogenetics Laboratory, Research 3, Massachusetts General Hospital, Boston
L. Farrer
Affiliation:
Neurogenetics Laboratory and School of Medicine, Boston University School of Medicine, Boston
R.H. Myers
Affiliation:
Neurogenetics Laboratory and School of Medicine, Boston University School of Medicine, Boston
J.F. Gusella
Affiliation:
Molecular Neurogenetics Laboratory, Research 3, Massachusetts General Hospital, Boston
*
Molecular Neurogenetics Lab, Research 3, Massachusetts General Hospital, 32 Fruit St., Boston MA, U.S.A. 02114
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The molecular genetic strategies aimed at isolating and characterizing the defective gene(s) in familial Alzheimer's disease, the inherent limitations of the techniques and recent progress in the field are reviewed. Three independent groups have found an apparent linkage to chromosome 21 but two other groups have not, suggesting that familial Alzheimer's disease may be etiologically heterogeneous.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue S4 , November 1989 , pp. 465 - 467
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

References

REFERENCES

1.Breitner, JC, Silverman, JS, Mohs, RC, et al. Familial aggregation in Alzheimer’s disease: comparison of risk among relatives of early and late onset cases and among male and female relatives in successive generations. Neurology 1988; 38: 207–212.CrossRefGoogle ScholarPubMed
2.Foncin, JF. Salmon, D, Supino-Viterbo, V. Demence Presenile D’Alzheimer Transmise Dans une Famille Etendu. Rev Neurol [Paris] 1985; 141: 194–202.Google Scholar
3.St.George-Hyslop, PH, Tanzi, RE, Polinsky, R, et al. Molecular genetics of autosomal dominant familial Alzheimer’s disease, In: Davies, P, Finch, CE, eds. Current Communications in Molecular Biology. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory (in press).Google Scholar
4.St.George-Hyslop, PH, Tanzi, RE, Polinsky, R, et al. The genetic defect causing familial Alzheimer’s disease maps on chromosome 21. Science 1987; 235: 885–890.CrossRefGoogle Scholar
5.Tanzi, RE, St. George-Hyslop, PH, Haines, JL, et al. The beta amyloid gene is not closely linked to the FAD defect. Nature 1988; 331: 528–530.CrossRefGoogle ScholarPubMed
6.David, F, Lucotte, G. Co-segregation between D21S1S11 and the FAD gene in a pedigree. Alz Dis Assoc Disorders 1988; 2: 287.CrossRefGoogle Scholar
7.Goate, A, Haynes, AR, Owen, MJ, et al. Predisposing locus for Alzheimer’s disease on chromosome 21. Lancet 1989; 1: 352–355.CrossRefGoogle ScholarPubMed
8.Van Broeckhoven, C, Van Hul, W, Backhoeven, H, et al. The familial Alzheimer’s disease gene is located close to the centromere of chromosome 21. Am J Hum Gen 1988; 43: 8205.Google Scholar
9.Roses, AD, Pericak-Vance, MA, Dawson, DV, et al. Standard likeli-hood and sibpair linkage analysis in late-onset Alzheimer’s disease. In: Davies, P, Finch, CE, eds. Current Communications in Molecular Biology. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory (in press).Google Scholar
10.Schellenberg, CD, Bird, TD, Wijsman, EM, et al. Absence of linkage of chromosome 21 q21 markers to familial Alzheimer’s disease. Science 1988; 241: 1507–1510.CrossRefGoogle ScholarPubMed
11.Heyman, A, Wilkinson, WF, Hurwitz, BJ, et al. Alzheimer’s disease: genetic aspects and associated clinical disorder. Ann Neurol 1983; 14: 507–515.CrossRefGoogle Scholar
12.Farrer, LA, O’Sullivan, DM, Cupples, LA, et al. Assessment of genetic risk of Alzheimer’s disease among first-degree relatives. Ann Neurol (in press).Google Scholar
13.Chandra, V, Philipose, V, Bell, PA, et al. Case control study of late onset “probable Alzheimer’s disease”. Neurology 1987; 37: 1295–1300.CrossRefGoogle ScholarPubMed
14.Nee, LE, Eldridge, R, Sunderland, T, et al. Dementia of the Alzheimer type: clinical and family study of 22 twin pairs. Neurology 1987; 37: 359–363.CrossRefGoogle ScholarPubMed