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New Developments in the Surgery for Parkinson's Disease

Published online by Cambridge University Press:  02 December 2014

Christopher Honey ,
R.E. Gross  and
A.M. Lozano
Christopher Honey
Affiliation:
Division of Neurosurgery, Department of Surgery, University of British Columbia
R.E. Gross
Affiliation:
University of Toronto
A.M. Lozano
Affiliation:
University of Toronto
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Abstract

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Despite optimization of medical therapy, a large number of patients with Parkinson's disease continue to be disabled. For this group, alternate treatment strategies such as neurosurgical intervention can be considered. Recent advances in neurosurgical techniques and in understanding the pathophysiology of motor disturbances in PD have made surgery safer and more effective. Functional neurosurgical procedures to lesion or electrically modulate dysfunctional basal ganglia circuits or to protect or restore dopaminergic transmission are being increasingly used. These procedures are having a profound impact on the motor disturbances of PD and are producing important improvements in quality of life of patients.

Résumé

RÉSUMÉ

Malgré des améliora-tions importantes dans le traitement de la maladie de Parkinson (MP), un grand nombre de patients demeurent invalides. Pour ce groupe de patients, d'autres stratégies de traitement comme la neurochirurgie peuvent être con-sidérées. Les progrès techniques récents en neurochirurgie et dans la compréhension de la physiopathologie des troubles moteurs dans la MP ont diminué les risques de la chirurgie et ont augmenté son efficacité. Les interven-tions neurochirurgicales fonctionnelles pour créer une lésion ou moduler électriquement les circuits dysfonction-nels ou pour protéger ou rétablir la transmission dopaminergique sont de plus en plus utilisées. Ces interventions ont un impact important sur les troubles moteurs dans la MP et procurent aux patients des améliorations impor-tantes de leur qualité de vie.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 26 , Issue S2 , August 1999 , pp. S45 - S52
Copyright
Copyright © The Canadian Journal of Neurological 1999

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