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On the Urgent Need for Successful Randomized Controlled Trials in Neurosciences

Published online by Cambridge University Press:  02 December 2014

Samuel Wiebe  and
Michael D. Hill
Samuel Wiebe
Affiliation:
University of Calgary, Calgary, Alberta, Canada
Michael D. Hill
Affiliation:
University of Calgary, Calgary, Alberta, Canada
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Abstract

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Type
Editorial
Information
Canadian Journal of Neurological Sciences , Volume 38 , Issue 3 , May 2011 , pp. 383 - 384
Copyright
Copyright © The Canadian Journal of Neurological 2011

References

1 Sackett, DL. Bias in analytic research. J Chronic Dis. 1979;32: 51–63.CrossRefGoogle ScholarPubMed
2 MRC Streptomycin in Tuberculosis Trials Committee. Streptomycin treatment for pulmonary tuberculosis. Br Med J. 1948;ii:769–82.Google Scholar
3 Schulz, KF, Chalmers, I, Hayes, RJ, Altman, DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273(5):408–12.CrossRefGoogle ScholarPubMed
4 The EC/IC Bypass Study Group. Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke. N Engl J Med. 1985;313:1191–200.CrossRefGoogle Scholar
5 Sackett, DL, Hoey, J. Why randomized controlled trials fail but needn’t: a new series is launched. CMAJ. 2000 May 2;162(9): 1301–2.Google ScholarPubMed
6 Hebert, PC, Fergusson, DA. Are we keeping research participants safe enough? CMAJ. 2010 July 13;182(10):E428.CrossRefGoogle ScholarPubMed
7 Lehrer, J. The truth wears off. Is there something wrong with the scientific method? The New Yorker. 2010 December 13.Google Scholar
8 Ioannidis, JP. Contradicted and initially stronger effects in highly cited clinical research. JAMA. 2005 July 13;294(2):218–28.CrossRefGoogle ScholarPubMed