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Pathological Diversity in Clinical Syndromes of Pituitary Hypersecretion: Its Significance in Evaluating their Surgical Treatment

Published online by Cambridge University Press:  18 September 2015

Harley S. Smyth
Harley S. Smyth*
Affiliation:
Division of Neurosurgery, The Wellesley Hospital, University of Toronto
*
The Wellesley Hospital of the 160 Wellesley St. E., Room 113, Toronto, Ontario, Ontario M4Y 1J3
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Abstract:

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Thorough pathological examination disclosed considerable diversity of abnormal cell types and correspondingly different surgical correction rates among patients with apparently similar syndromes of pituitary hypersecretion.The surgical correction of acromegaly in patients with densely granulated growth hormone tumours was threefold that in patients whose tumours showed sparse granulation. Two non-prolactinoma tumour types associated with hyperprolactinemia have aggressive growth patterns; their special therapeutic management is discussed. Of 33 patients with Cushing's disease solitary adenomas were found in only 14, while six patients had proven corticotroph cell hyperplasia. Elective hypophysectomy should replace selective adenomectomy in selected cases of Cushing's disease.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 12 , Issue S4 , November 1985 , pp. 358 - 362
Copyright
Copyright © Canadian Neurological Sciences Federation 1985

References

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