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Similarities of Guamanian ALS/PD to Post-Encephalitic Parkinsonism/ALS: Possible Viral Cause

Published online by Cambridge University Press:  18 September 2015

Arthur J. Hudson  and
George P.A. Rice
Arthur J. Hudson*
Affiliation:
Department of Clinical Neurological Sciences, University Hospital, London, Ontario
George P.A. Rice
Affiliation:
Department of Clinical Neurological Sciences, University Hospital, London, Ontario
*
Dept. of Clinical Neurological Sciences, University Hospital, 339 Windermere Rd., London, Ontario, Canada N6A 5A5
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Abstract:

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Guamanian amyotrophic lateral sclerosis with parkinsonism-dementia (ALS/PD) has been the subject of intensive study since its discovery in 1947 because of its extraordinarily high incidence in a small ethnic group (Chamorros) whose dietary lack and customs have suggested possible causes. As yet, these and other suspected causes have eluded proof. Because of marked similarities between Guamanian ALS/PD and late onset post-encephalitic (encephalitis lethargica) parkinsonism and ALS it is suggested that they have a common cause. The parkinsonism and ALS in the two disorders are clinically very similar and neuropathological studies have shown a very similar distribution of neurofibrillary tangles in neurons. Some clinical differences, such as ocular features in the post-encephalitic cases and dementia in Guamanian ALS/PD, can be explained by differences in the severity of infection and the interval between the encephalitis and onset of sequelae. Although unproven, influenza A (HswilNl strain) has long been suspected as the cause of encephalitis lethargica because of simultaneous pandemics of the two diseases in the 1920s. Because influenza A can persistently infect cells and has a marked propensity to mutate it is an optimal candidate among other RNA viruses for delayed nervous system infection as a possible cause of ALS/PD.

Type
Special Features
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 4 , November 1990 , pp. 427 - 433
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

REFERENCES

1.von Economo, C.Encephalitis lelhargica: its sequelae and treatment. London: Oxford University Press, 1931.Google Scholar
2.Mulder, DW, Kurland, LT, Iriarte LLC Neurologic diseases on the Island of Guam. U.S. Armed Forces Med J 1954; 5: 1724–1739.Google Scholar
3.Hirano, A, Kurland, LT, Krooth, RS, et al. Parkinsonism-dementia complex, an endemic disease on the Island of Guam. 1. Clinical features. Brain 1961; 84: 642–661.CrossRefGoogle Scholar
4.Armon, C, Kurland, LT.Classic and Western Pacific amyotrophic lateral sclerosis: epidemiologic comparisons. In: Hudson, AJ, ed. Amyotrophic lateral sclerosis: concepts in pathogenesis and etiology. Toronto: University of Toronto Press, 1990; 144–165.Google Scholar
5.Steele, JC, Guzman, TQ, Driver, MG, et al. Nutritional factors in amyotrophic lateral sclerosis on Guam: observations from Umatac. In: Hudson, AJ, ed. Amyotrophic lateral sclerosis: concepts in pathogenesis and etiology. Toronto: University of Toronto Press, 1990; 193–223.Google Scholar
6.Garruto, RM, Swyt, C, Yanagihara, R, et al. Intraneuronal co-localization of silicon with calcium and aluminum in amyotrophic lateral sclerosis and parkinsonism with dementia of Guam. New Engl J Med 1986; 315: 711–712.Google ScholarPubMed
7.Spencer, PS, Nunn, PB, Hugon, J, et al. Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin. Science 1987; 237: 517–522.CrossRefGoogle ScholarPubMed
8.Gajdusek, DC.Cycad toxicity not the cause of high-incidence amyotrophic lateral sclerosis/parkinsonism-dementia on Guam. Kii Peninsula of Japan, or in West New Guinea. In: Hudson, AJ, ed. Amyotrophic lateral sclerosis: concepts in pathogenesis and etiology, Toronto: University of Toronto Press, 1990; 317–325.Google Scholar
9.Grima, EA, Bergeron, C, Crapper McLachlan, DR.Evaluation of environmental factors in the etiopathogenesis of the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. In: Hudson, AJ, ed. Amyotrophic lateral sclerosis: concepts in pathogenesis and etiology. Toronto: University of Toronto Press, 1990; 224–262.Google Scholar
10.Gibbs, CJ Jr, Gajdusek, DC.Amyotrophic lateral sclerosis, Parkinson's disease, and the amyotrophic lateral sclerosis-parkinsonism-dementia complex on Guam: a review and summary of attempts to demonstrate infection as the aetiology. J Clin Pathol 1972; 25 (Suppl): 132–140.CrossRefGoogle Scholar
11.Duvoisin, RC, Yahr, MD.Encephalitis and parkinsonism. Arch Neurol 1965; 12: 227–239.Google ScholarPubMed
12.Kohne, DE, Gibbs, CJ, White, L, et al. Virus detection by nucleic acid hybridization: examination of normal and ALS tissues for the presence of poliovirus. J Gen Virol 1981; 56: 223–233.CrossRefGoogle ScholarPubMed
13.Viola, MV, Lazarus, M, Antel, J, et al. Nucleic acid probes in the study of amyotrophic lateral sclerosis. In: Rowland, Lewis P. ed. Human motor neuron diseases. New York: Raven Press, 1982; 317–329.Google Scholar
14.Pena, GE.Viruslike particles in amyotrophic lateral sclerosis. Electron microscopical study of a case. Ann Neurol 1977; 1: 290–297.CrossRefGoogle ScholarPubMed
15.Oshiro, LS, Cremer, NE, Norris, FH, et al. Viruslike particles in muscle from a patient with amyotrophic lateral sclerosis. Neurology 1976; 26: 57–60.CrossRefGoogle ScholarPubMed
16.Kascsak, RJ, Carp, RI, Vilcek, JT, et al. Virological studies in amyotrophic lateral sclerosis. Muscle & Nerve 1982; 5: 93–101.Google ScholarPubMed
17.Gibbs, CJ, Gajdusek, DC.An update on long-term in vivo and in vitro studies designed to identify a virus as the cause of amyotrophic lateral sclerosis, parkinsonism dementia, and Parkinson’s disease. In: Rowland, LP, ed. Human motor neuron diseases. New York: Raven Press, 1982; 343–353.Google Scholar
18.Weiner, LP, Stohlman, SA, Davis, RL.Attempts to demonstrate virus in amyotrophic lateral sclerosis. Neurology 1980; 30: 1319–1322.CrossRefGoogle ScholarPubMed
19.Maurizi, CP.Was a neurovirulent influenza virus the cause of amyotrophic lateral sclerosis and parkinsonism-dementia on Guam? Medical Hypotheses 1987; 23: 325–326.CrossRefGoogle ScholarPubMed
20.O’Brien, SJ, Roelke, ME, Marker, L, et al. Genetic basis for species vulnerability in the cheetah. Science 1985; 227: 1428–1434.CrossRefGoogle ScholarPubMed
21.Laing, P, Knight, JG, Hill, JM, et al. Influenza viruses induce autoantibodies to a brain-specific 37-KDa protein in rabbit. Proc Natl Acad Sci 1989; 86: 1998–2002.CrossRefGoogle ScholarPubMed
22.Matheson Commission. Epidemic encephalitis; etiology, epidemiology, treatment. New York: Columbia University Press, 1929; 179–399.Google Scholar
23.Ravenholt, RT, Foege, WH.1918 influenza, encephalitis lethargica, parkinsonism. Lancet 1982; 2: 860–864.CrossRefGoogle ScholarPubMed
24.Arnold, A, Edgren, DC, Palladino, VS.Amyotrophic lateral sclerosis. Fifty cases observed on Guam. J Nerv Ment Dis 1953; 117: 135–139.Google ScholarPubMed
25.Hirano, A, Malamud, N, Kurland, LT.Parkinsonism-dementia complex, endemic disease on the Island of Guam. II. Pathological features. Brain 1961; 84: 662–679.CrossRefGoogle ScholarPubMed
26.Dimsdale, H.Changes in the parkinsonian syndrome in the twentieth century. Quart J Med 1946; 15: 155–170.CrossRefGoogle ScholarPubMed
27.Brain, WR.Diseases of the Nervous System. London: Oxford University Press, 4th edition, 1951.Google Scholar
28.Hudson, AJ. Amyotrophic lateral sclerosis and its association with dementia, parkinsonism and other neurological disorders. A review. Brain 1981; 104: 217–247.CrossRefGoogle ScholarPubMed
29.Elizan, TS, Hirano, A, Abrams, BM, et al. Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam. Arch Neurol 1966; 14: 356–368.Google ScholarPubMed
30.von Braunmuhl, AV.Encephalitis epidemica und synaresislehre. Grundsatzliches zure anatomie und Pathogenese des posten-cephalitischen parkinsonismus. Archiv Psychiatrie 1949; 181: 543–576.Google Scholar
31.Greenfield, JG, Matthews, WB.Post-encephalitic parkinsonism with amyotrophy. J Neurol Neurosurg Psychiatry 1954; 17: 50–56.CrossRefGoogle ScholarPubMed
32.Greenfield, JG, Bosanquet, FD.The brain-stem lesions in parkinsonism. J Neurol Neurosurg Psychiatry 1953; 16: 213–226.CrossRefGoogle ScholarPubMed
33.Hirano, A, Zimmerman, HM.Alzheimer’s neurofibrillary changes: a topographic study. Arch Neurol 1962; 7: 227–242.CrossRefGoogle ScholarPubMed
34.McMenemey, WH, Barnard, RO, Jellinek, EH.Spinal amyotrophy. A late sequel of epidemic encephalitis (von Economo). Revue Roumaine du Neurologie 1967; 4: 251–259.Google Scholar
35.Gajdusek, DC.Hypothesis: interference with axonal transport of neurofilament as a common pathogenetic mechanism in certain diseases of the central nervous system. New Engl J Med 1985; 312: 714–719.CrossRefGoogle ScholarPubMed
36.Corsellis, JAN.Sub-acute sclerosing leuco-encephalitis: a clinical and pathological report of two cases. J. Ment Sci 1951; 97: 570–583.Google ScholarPubMed
37.Edgren, DC, Palladino, VS, Arnold, A.Japanese B and mumps encephalitis. A clinicopathological report of simultaneous outbreaks on the Island of Guam. Am J Trop Med Hyg 1958; 7: 471–480.CrossRefGoogle Scholar
38.Hammon, WMcD, Tigertt, WD, Sather, GE, et al. Epidemiologic studies of concurrent “virgin” epidemics of Japanese B encephalitis and of mumps on Guam, 1947–1948, with subsequent observations including dengue, through 1957. Am J Trop Med Hyg 1958; 7: 441–468.CrossRefGoogle ScholarPubMed
39.Crookshank, FG.Epidemic encephalomyelitis and influenza. Lancet 1919; 1: 79–80.CrossRefGoogle Scholar
40.Poskanzer, DC, Schab, RS.Cohort analysis of Parkinson’s syndrome: evidence for a single aetiology related to subclinical infection about 1920. J Chron Dis 1963; 16: 961–973.CrossRefGoogle ScholarPubMed
41.Gamboa, ET, Wolf, A, Yahr, MD, et al. Influenza virus antigen in postencephalitic parkinsonism brain: detection by immunofluorescence. Arch Neurol 1974; 31: 228–232.Google ScholarPubMed
42.Mattock, C, Marmot, M, Stern, G.Could Parkinson’s disease follow intra-uterine influenza?: a speculative hypothesis. J Neurol Neurosurg Psychiatry 1988; 51: 753–756.Google ScholarPubMed
43.Ebmeier, KP, Mutch, WJ, Calder, SA, et al. Does idopathic parkinsonism in Aberdeen follow intrauterine influenza? J Neurol Neurosurg Psychiatry 1989; 52: 911–913.CrossRefGoogle Scholar
44.Elizan, TS, Casals, J.No viral antigens detected in brain tissue from a case of acute encephalitis lethargica and another case of postencephalitic parkinsonism. J Neurol Neurosurg Psychiatry 1989; 52: 800–801.CrossRefGoogle Scholar
45.Singer, C, Weiner, WJ.Could Parkinson’s disease follow intra-uterine influenza? A speculative hypothesis. J Neurol Neurosurg Psychiatry 1989; 52: 931.CrossRefGoogle ScholarPubMed
46.Stuart-Harris, CH, Schild, GC, Oxford, JS.Influenza. The viruses and the diseases. London: Edward Arnold Ltd, 2nd edition, 1985.Google Scholar
47.Espir, MLE, Spalding, JMK. Three recent cases of encephalitis lethargica. Br Med J 1956; 1: 1141–1144.Google ScholarPubMed
48.Clough, CG, Plaitakis, A, Yahr, MD.Oculogyric crises and parkinsonism: a case of recent onset. Arch Neurol 1983; 40: 36–37.Google ScholarPubMed
49.Howard, RS, Lees, AJ.Encephalitis lethargica: a report of four recent cases. Brain 1987; 110: 19–33.Google ScholarPubMed
50.Johnson, J, Lucey, PA.Encephalitis lethargica, a contemporary cause of catatonic stupor: a report of 2 cases. Br J Psychiatry 1987; 151: 550–552.CrossRefGoogle Scholar
51.Hope-Simpson, RE, Golubev, DB.A new concept of the epidemic process of influenza A virus. Epidem Inf 1987; 99: 5–54.CrossRefGoogle ScholarPubMed
52.Stuart-Harris, CH.A neurotropic strain of human influenza virus. Lancet 1939; 1: 497–499.CrossRefGoogle Scholar
53.Armstrong, CL, Miranda, AF, Hsu, KC, et al. Susceptibility of human skeletal muscle culture to influenza virus infection. I. Cytopathology and immunofluorescence. J Neurol Sci. 1978; 35: 43–57.Google ScholarPubMed
54.Holland, JJ, Grabau, EA, Jones, CL, et al. Evolution of multiple genome mutations during long term persistent infection by vesicular stomatitis virus. Cell 1979; 16: 495–504.Google ScholarPubMed
55.Editorial. Puzzling diversity of rotaviruses. Lancet 1990; 1: 573–574.Google Scholar