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Sporadic Creutzfeldt-Jakob Disease with Worsening Depression and Cognition

Published online by Cambridge University Press:  02 December 2014

Mark Hudon ,
Richard Farb ,
Taim Muayqil  and
Zaeem A. Siddiqi
Mark Hudon
Affiliation:
Division of Neurology, Department of Medicine, Walter C. Mackenzie Health Sciences Center, University of Alberta, Edmonton, Alberta, Canada
Richard Farb
Affiliation:
Division of Neurology, Department of Medicine, Walter C. Mackenzie Health Sciences Center, University of Alberta, Edmonton, Alberta, Canada
Taim Muayqil
Affiliation:
Division of Neurology, Department of Medicine, Walter C. Mackenzie Health Sciences Center, University of Alberta, Edmonton, Alberta, Canada
Zaeem A. Siddiqi
Affiliation:
Division of Neurology, Department of Medicine, Walter C. Mackenzie Health Sciences Center, University of Alberta, Edmonton, Alberta, Canada
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A 58-year-old male presented with a one-year history of low mood, early morning awakening from sleep, apathy, difficulty with memory, concentration and organization. This had been associated with intrusive concerns of a recent social stressor. He was no longer able to work and was on medical disability. Except for a 20kg weight loss there were no other constitutional or neurological symptoms. He had hypertension and hypercholesterolemia and was on atorvastatin and aspirin. He scored 28/30 on mini-mental status examination (MMSE) with errors on object recall; however he could recall forgotten items after cueing. He had difficulty with concentration, was apathic andhad a negative outlook to the future. His neurological examination and a detailed hematological work up including chemistry, cell counts, vitamin B12, folate, and renal, hepatic and thyroid function tests were normal. A brain magnetic resonance image (MRI) showed mild cerebral atrophy. Based on a formal neuropsychological assessment he was diagnosed with depression and started on Venlafaxine.

Type
Neuroimaging Highlight
Information
Canadian Journal of Neurological Sciences , Volume 34 , Issue 4 , November 2007 , pp. 464 - 466
Copyright
Copyright © The Canadian Journal of Neurological 2007

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