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Stereotactic Radiotherapy: An Emerging Treatment for Spinal Metastases

Published online by Cambridge University Press:  02 December 2014

Max Dahele*
Affiliation:
Department of Radiation Oncology, VU University Medical Centre, Amsterdam, The Netherlands
Michael G. Fehlings
Affiliation:
Division of Neurosurgery and Spinal Program, Toronto Western Hospital
Arjun Sahgal
Affiliation:
Department of Radiation Oncology, Princess Margaret Hospital and Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, Ontario, Canada
*
Department of Radiation Oncology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
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Abstract

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Aim:

The purpose of this concise update is to describe the emerging treatment of stereotactic body radiotherapy (SBRT) for spinal metastases.

Rationale:

Spinal metastases are common and can present complex clinical challenges that conventional treatment cannot always meet satisfactorily. Examples include a history of prior irradiation at the same site or radio-resistant tumor histology. Stereotactic body radiotherapy makes it possible to deliver high doses of radiation with the aim of improving tumor control and palliation. It is increasingly being offered to selected patients including those requiring re-irradiation and post-operative treatment.

Conclusion:

It is important that specialists managing patients with spinal metastases are aware of the potential advantages of SBRT and how this can complement and extend existing treatment approaches, including spinal decompression and stabilization.

Type
Original Article
Copyright
Copyright © The Canadian Journal of Neurological 2011

References

1Sciubba, DM, Petteys, RJ, Dekutoski, MB, et al.Diagnosis and management of metastatic spine disease. J Neurosurg Spine. 2010;13:94108.Google Scholar
2Fisher, CG, Dipaola, CP, Ryken, TC, et al.A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the spine oncology study group. Spine (Phila Pa 1976). 2010;35E12219.Google Scholar
3Gerszten, PC, Monaco, EA, 3rd, Quader, M, et al.Setup accuracy of spine radiosurgery using cone beam computed tomography image guidance in patients with spinal implants. J Neurosurg Spine. 2010;12:41320.Google Scholar
4Sahgal, A, Ma, L, Gibbs, I, et al.Spinal cord tolerance for stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2010;77:54853.Google Scholar
5Sahgal, A, Larson, DA, Chang, EL.Stereotactic body radiosurgery for spinal metastases: a critical review. Int J Radiat Oncol Biol Phys. 2008;71:65265.Google Scholar
6Gerszten, PC, Burton, SA, Ozhasoglu, C, Welch, WC.Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution. Spine. 2007;32:1939.CrossRefGoogle ScholarPubMed
7Sze, WM, Shelley, M, Held, I, et al.Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy - a systematic review of the randomised trials. Cochrane Database Syst Rev. 2004;(2):CD004721.Google Scholar
8Mizumoto, M, Harada, H, Asakura, H, et al.Radiotherapy for patients with metastases to the spinal column: a review of 603 patients at Shizuoka Cancer Center Hospital. Int J Radiat Oncol Biol Phys. 2011;79:20813.Google Scholar
9Milano, MT, Katz, AW, Muhs, AG, et al.A prospective pilot study of curative-intent stereotactic body radiation therapy in patients with 5 or fewer oligometastatic lesions. Cancer. 2008;112:6508.Google Scholar
10Sahgal, A, Bilsky, M, Chang, EL, et al.Stereotactic body radiotherapy for spinal metastases: current status, with a focus on its application in the postoperative patient. J Neurosurg Spine. 2010 Dec 24. [Epub ahead of print].Google Scholar