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13th Annual C. Walton Lillehei Memorial Lecture – Invisible problems in cardiovascular surgery: What we can learn from prospective observational studies?*

  • James S. Tweddell (a1)
Corresponding author
Correspondence to: Dr J. S. Tweddell, MD, The Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin and the Herma Heart Center, Children's Hospital of Wisconsin, 900 W. Wisconsin Avenue, Milwaukee, Wisconsin 53226, United States of America; E-mail:
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Presented at: The Children's Hospital of Philadelphia Cardiology 2012, 16th Annual Update on Pediatric and Congenital Cardiovascular Disease, Orlando, Florida, February 22–26, 2012.

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1. Tweddell JS, Hoffman GM, Fedderly RT, et al. Phenoxybenzamine improves systemic oxygen delivery after the Norwood procedure. Ann Thorac Surg 1999; 67: 161167; discussion 167–168.
2. Tweddell JS, Hoffman GM, Mussatto KA, et al. Improved survival of patients undergoing palliation of hypoplastic left heart syndrome: lessons learned from 115 consecutive patients. Circulation 2002; 106 (Suppl 1): I82I89.
3. Hoffman GM, Tweddell JS, Ghanayem NS, et al. Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the Norwood procedure. J Thorac Cardiovasc Surg 2004; 127: 738745.
4. Tweddell JS, Ghanayem NS, Mussatto KA, et al. Mixed venous oxygen saturation monitoring after stage 1 palliation for hypoplastic left heart syndrome. Ann Thorac Surg 2007; 84: 13011310; discussion 1310–1301.
5. Hoffman GM, Mussatto KA, Brosig CL, et al. Systemic venous oxygen saturation after the Norwood procedure and childhood neurodevelopmental outcome. J Thorac Cardiovasc Surg 2005; 130: 10941100.
6. Ghanayem NS, Hoffman GM, Mussatto KA, et al. Perioperative monitoring in high-risk infants after stage 1 palliation of univentricular congenital heart disease. J Thorac Cardiovasc Surg 2010; 140: 857863.
7. Hoffman GM, Ghanayem NS, Kampine JM, et al. Venous saturation and the anaerobic threshold in neonates after the Norwood procedure for hypoplastic left heart syndrome. Ann Thorac Surg 2000; 70: 15151520; discussion 1521.
8. Hoffman GM, Ghanayem NS, Mussatto KA, Berens RJ, Tweddell JS. Postoperative two-site NIRs predicts complications and mortality after stage 1 palliation of HLHS. Anesthesiology 2007; 107: A234.
9. Hoffman GM, Ghanayem NS, Stuth EA, Berens RJ, Tweddell JS. NIRS-derived somatic and cerebral saturation difference provides non-invasive real-time hemodynamic assessment of cardiogenic shock and risk of anaerobic metabolism. Anesthesiology 2004; 99: A-1514.
10. Hoffman GM, Mussatto KA, Brosig CL, Tweddell JS, Ghanayem NS. Cerebral oxygenation and neurodevelopmental outcome in hypoplastic left heart syndrome. Anesthesiology 2008; 109: A7.
11. Hoffman GM, Ghanayem NS, Mussatto KA, et al. Perioperative somatic near-infrared spectroscopy predicts postoperative renal function following neonatal cardiac surgery. Circulation 2005; 112 (Suppl 2): II-367.
12. Stampfer MJ, Colditz GA. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med 1991; 20: 4763.
13. Grady D, Rubin SM, Petitti DB, et al. Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Intern Med 1992; 117: 10161037.
14. Psaty BM, Heckbert SR, Atkins D, et al. The risk of myocardial infarction associated with the combined use of estrogens and progestins in postmenopausal women. Arch Intern Med 1994; 154: 13331339.
15. Sidney S, Petitti DB, Quesenberry CP Jr. Myocardial infarction and the use of estrogen and estrogen–progestogen in postmenopausal women. Ann Intern Med 1997; 127: 501508.
16. Cauley JA, Cummings SR, Black DM, Mascioli SR, Seeley DG. Prevalence and determinants of estrogen replacement therapy in elderly women. Am J Obstet Gynecol 1990; 163 (Pt 1): 14381444.
17. Barrett-Connor E. Postmenopausal estrogen and prevention bias. Ann Intern Med 1991; 115: 455456.
18. Petitti DB. Coronary heart disease and estrogen replacement therapy. Can compliance bias explain the results of observational studies? Ann Epidemiol 1994; 4: 115118.
19. Beral V, Banks E, Reeves G. Evidence from randomised trials on the long-term effects of hormone replacement therapy. Lancet 2002; 360: 942944.
20. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. JAMA 2002; 288: 321333.
21. Ohye RG, Sleeper LA, Mahony L, et al. Comparison of shunt types in the Norwood procedure for single-ventricle lesions. N Engl J Med 2010; 362: 19801992.
22. Addonizio LJ. Pediatric ventricular assist devices – first steps for babies. N Engl J Med 2012; 367: 567568.
23. Almond CS, Buchholz H, Massicotte P, et al. Berlin heart EXCOR pediatric ventricular assist device investigational device exemption study: study design and rationale. Am Heart J 2011; 162: 425435; e426.
24. Foreman C. H100004, HUD Number: 2000-0064, Berlin Heart EXCOR Pediatric Assist Device (VAD), 2011.
25. Fraser CD, Jaquiss RDB, Rosenthal DN, et al. Prospective trial of a pediatric ventricular assist device. N Engl J Med 2012; 367: 532541.
26. Royston D, Bidstrup BP, Taylor KM, Sapsford RN. Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet 1987; 2: 12891291.
27. Henry DA, Moxey AJ, Carless PA, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2001; 1: CD001886.
28. Sedrakyan A, Treasure T, Elefteriades JA. Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: a systematic review and meta-analysis of randomized clinical trials. J Thorac Cardiovasc Surg 2004; 128: 442448.
29. Mangano DT, Tudor IC, Dietzel C. The risk associated with aprotinin in cardiac surgery. N Engl J Med 2006; 354: 353365.
30. Mangano DT, Miao Y, Vuylsteke A, et al. Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA 2007; 297: 471479.
31. Bekelman JE, Li Y, Gross CP. Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA 2003; 289: 454465.
32. Fergusson DA, Hebert PC, Mazer CD, et al. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med 2008; 358: 23192331.
33. Benson K, Hartz AJ. A comparison of observational studies and randomized, controlled trials. N Engl J Med 2000; 342: 18781886.
34. Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 2000; 342: 18871892.
35. Ioannidis JP, Haidich AB, Pappa M, et al. Comparison of evidence of treatment effects in randomized and nonrandomized studies. JAMA 2001; 286: 821830.
36. Tricoci P, Allen JM, Kramer JM, Califf RM, Smith SC Jr. Scientific evidence underlying the ACC/AHA clinical practice guidelines. JAMA 2009; 301: 831841.
37. Hammill BG, Hernandez AF, Peterson ED, Fonarow GC, Schulman KA, Curtis LH. Linking inpatient clinical registry data to Medicare claims data using indirect identifiers. Am Heart J 2009; 157: 9951000.
38. Dokholyan RS, Muhlbaier LH, Falletta JM, et al. Regulatory and ethical considerations for linking clinical and administrative databases. Am Heart J 2009; 157: 971982.
39. Hernandez AF, Hammill BG, Peterson ED, et al. Relationships between emerging measures of heart failure processes of care and clinical outcomes. Am Heart J 2010; 159: 406413.
40. Pasquali SK, Jacobs JP, Shook GJ, et al. Linking clinical registry data with administrative data using indirect identifiers: implementation and validation in the congenital heart surgery population. Am Heart J 2010; 160: 10991104.
41. Pasquali SK, Li JS, He X, et al. Comparative analysis of antifibrinolytic medications in pediatric heart surgery. J Thorac Cardiovasc Surg 2012; 143: 550557.
42. Kaltman JR, Andropoulos DB, Checchia PA, et al. Report of the Pediatric Heart Network and National Heart, Lung, and Blood Institute Working Group on the perioperative management of congenital heart disease. Circulation 2010; 121: 27662772.
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Cardiology in the Young
  • ISSN: 1047-9511
  • EISSN: 1467-1107
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