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Etoposide-related cardiotoxicity in a child with haemophagocytic lymphohistiocytosis

  • Heather Escoto (a1), Jeremy Ringewald (a2) and Ram Kalpatthi (a1)
  • DOI:
  • Published online: 25 February 2010

We report a male child with haemophagocytic lymphohistiocytosis who developed myocardial infarction after receiving etoposide. He recovered well with supportive measures and after discontinuation of etoposide. We discuss the possible mechanisms and differential diagnoses of myocardial infarction in our patient.

Corresponding author
Correspondence to: Ram Kalpatthi, MD, Division of Pediatric Hematology Oncology, Children’s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108. Tel: 816-234-3265; Fax: 816-855-1700; E-mail:
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1.B Ozben , R Kurt , H Oflaz , Acute anterior myocardial infarction after chemotherapy for testicular seminoma in a young patient. Clin Appl Thromb Hemost 2007; 13: 439442.

3.CL Airey , DJ Dodwell , JK Joffe , WG Jones . Etoposide-related myocardial infarction. Clin Oncol (R Coll Radiol) 1995; 7: 135.

4.J Aisner , DA Van Echo , M Whitacre , PH Wiernik . A phase I trial of continuous infusion VP16-213 (etoposide). Cancer Chemother Pharmacol 1982; 7: 157160.

7.Y Takeoka , M Nakamae , H Nakamae , Two cases of ampulla (takotsubo-shaped) cardiomyopathy associated with hemophagocytic lymphohistiocytosis. Acta Haematol 2007; 117: 205210.

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Cardiology in the Young
  • ISSN: 1047-9511
  • EISSN: 1467-1107
  • URL: /core/journals/cardiology-in-the-young
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