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    Amoozgar, Hamid Homayoon, Nahid Ajami, Gholamhossein Borzouee, Mohammad Cheriki, Sirous and Edraki, Mohammadreza 2016. Epidemiological Characteristics and Clinical Outcome of Syncope in Children; A Report from Shiraz, Iran. International Cardivascular Research Journal, Vol. 10, Issue. 1, p. 24.

    Anderson, Jeffrey B. Willis, Martha Lancaster, Heidi Leonard, Karen and Thomas, Cameron 2016. The Evaluation and Management of Pediatric Syncope. Pediatric Neurology, Vol. 55, p. 6.

    Grimaldi Capitello, Teresa Fiorilli, Caterina Placidi, Silvia Vallone, Roberta Drago, Fabrizio and Gentile, Simonetta 2016. What factors influence parents’ perception of the quality of life of children and adolescents with neurocardiogenic syncope?. Health and Quality of Life Outcomes, Vol. 14, Issue. 1,

    Ayers, Mark D. and Lawrence, David K. 2015. Near-infrared Spectroscopy to Assess Cerebral Perfusion during Head-up Tilt-table Test in Patients with Syncope. Congenital Heart Disease, Vol. 10, Issue. 4, p. 333.

    Silva, Neuza Carona, Carlos Crespo, Carla Bullinger, Monika and Canavarro, Maria Cristina 2014. The Portuguese DISABKIDS Asthma Module: a global index of asthma-specific quality of life for children and adolescents. Journal of Asthma, Vol. 51, Issue. 6, p. 645.


The effect of paediatric syncope on health-related quality of life

  • Jeffrey B. Anderson (a1), Richard J. Czosek (a1), Timothy K. Knilans (a1) and Bradley S. Marino (a1)
  • DOI:
  • Published online: 21 February 2012

Syncope is common in children and adolescents and most commonly represents neurocardiogenic syncope. No information has been reported regarding the effect of syncope on health-related quality of life in children.


This was a retrospective cohort study of patients seen in the Heart Institute Syncope Clinic at Cincinnati Children's Hospital Medical Center between July, 2009 and June, 2010. Health-related quality of life was assessed using the PedsQL™ tool. PedsQL™ scores were compared with both healthy historical controls and historical controls with chronic illnesses.


A total of 106 patients were included for analysis. In all, 90% were Caucasian and 63% were girls. The median age was 15.1 years (8.2–21.6). Compared with healthy controls, patients had lower PedsQL™ scores: Total score (75.2 versus 83.8, p < 0.0001); Physical Health Summary (78.8 versus 87.5, p < 0.0001); Psychosocial Health Summary (73.9 versus 81.9, p < 0.001), Emotional Functioning (68.9 versus 79.3, p < 0.001); and School Functioning (66.4 versus 81.1, p < 0.001). No difference was seen in Social Functioning (86.2 versus 85.2, p = 0.81). Patients also had lower PedsQL™ Total scores than patients with diabetes mellitus (p < 0.0001) and similar scores to patients with asthma, end-stage renal disease, obesity, and structural heart disease.


Children with syncope, although typically benign in aetiology, can have low health-related quality of life.

Corresponding author
Correspondence to: Dr J. Anderson, MD, MPH, The Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, ML 2003, Cincinnati, Ohio, United States of America. Tel: + 1 513 636 3865; Fax: + 1 513 636 3952; E-mail:
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Cardiology in the Young
  • ISSN: 1047-9511
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