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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Depping, Malte S. Wolf, Nadine D. Vasic, Nenad Sambataro, Fabio Thomann, Philipp A. and Wolf, R. Christian 2016. Common and distinct structural network abnormalities in major depressive disorder and borderline personality disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 65, p. 127.


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    Depping, Malte S. Wolf, Nadine D. Vasic, Nenad Sambataro, Fabio Thomann, Philipp A. and Christian Wolf, R. 2015. Specificity of abnormal brain volume in major depressive disorder: A comparison with borderline personality disorder. Journal of Affective Disorders, Vol. 174, p. 650.


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    Goodman, Marianne Carpenter, David Tang, Cheuk Y. Goldstein, Kim E. Avedon, Jennifer Fernandez, Nicolas Mascitelli, Kathryn A. Blair, Nicholas J. New, Antonia S. Triebwasser, Joseph Siever, Larry J. and Hazlett, Erin A. 2014. Dialectical behavior therapy alters emotion regulation and amygdala activity in patients with borderline personality disorder. Journal of Psychiatric Research, Vol. 57, p. 108.


    Richter, Julia Brunner, Romuald Parzer, Peter Resch, Franz Stieltjes, Bram and Henze, Romy 2014. Reduced cortical and subcortical volumes in female adolescents with borderline personality disorder. Psychiatry Research: Neuroimaging, Vol. 221, Issue. 3, p. 179.


    Giakoumaki, Stella G. Roussos, Panos Tsapakis, Eva-Maria Koiliari, Erasmia Pasparakis, Emmanouil Zouraraki, Chrysoula and Bitsios, Panos 2013. Cognitive and personality analysis of startle reactivity in a large cohort of healthy males. Biological Psychology, Vol. 94, Issue. 3, p. 582.


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Amygdalar Volume in Borderline Personality Disorder With and Without Comorbid Post-traumatic Stress Disorder: A Meta-analysis

  • Claudia P. de-Almeida (a1), Amy Wenzel (a2), Camila S. de-Carvalho (a1), Vania B. Powell (a1), César Araújo-Neto (a3), Lucas C. Quarantini (a1) and Irismar R. de-Oliveira (a1)
  • DOI: http://dx.doi.org/10.1017/S1092852912000466
  • Published online: 11 May 2012
Abstract
AbstractIntroduction

Four studies have found a smaller amygdalar volume in patients with borderline personality disorder (BPD) relative to controls, whereas four other studies have found similar amygdalar volume in BPD patients relative to controls. This study aims to compare amygdalar volumes of BPD patients with controls, and also to compare BPD patients with and without post-traumatic stress disorder (PTSD) with controls in order to determine whether PTSD can explain the heterogeneity of findings.

Method

Systematic review and meta-analysis of magnetic resonance imaging studies that measured amygdalar volumes in BPD patients and healthy controls.

Findings

A significant reduction of amygdalar volumes in BPD patients was confirmed (p < .001). However, data from the studies that discriminated BPD patients with and without PTSD indicated that amygdalar volumes were significantly smaller in BPD patients without PTSD relative to controls (left: p = .02; right: p = .05), but not in BPD patients with PTSD relative to controls (left: p = .08; right: p = .20).

Conclusion

This meta-analysis suggests that amygdalar volumes are reduced in patients with BPD. This pattern is confirmed in BPD patients without PTSD, but not in BPD patients with PTSD, raising the possibility that reduced amygdalar volume in BPD patients cannot be explained by comorbid PTSD.

Copyright
Corresponding author
*Address for correspondence: Irismar Reis de Oliveira, MD, PhD, Department of Neurosciences and Mental Health, Federal University of Bahia, Avenida Reitor Miguel Calmon, s/no, Vale do Canela, Salvador, Bahia, 40110-905, Brazil. Tel: 55-71-32417154, Fax: 55-71-32417154. Web site: http://www.trial-basedcognitivetherapy.com.(E-mail: irismar.oliveira@uol.com.br) [I.R. d-O](E-mail: claudinhapa@yahoo.com.br) [C.P. d-A](E-mail: awenzel@dramywenzel.com) [A.W](E-mail: camila_seixas@yahoo.com.br) [C.S. d-C](E-mail: vania_powell@yahoo.com.br) [V.B.P](E-mail: caaneto@gmail.com) [C.A-N](E-mail: quarantini@gmail.com) [L.C.Q]
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CNS Spectrums
  • ISSN: 1092-8529
  • EISSN: 2165-6509
  • URL: /core/journals/cns-spectrums
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