Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-10T19:48:35.972Z Has data issue: false hasContentIssue false

Treatment of Obsessive-Compulsive Syndromes in Schizophrenia

Published online by Cambridge University Press:  07 November 2014

Abstract

While obsessive-compulsive (OC) symptoms in schizophrenia have been reported for many years, they have achieved only limited recognition and, perhaps for this reason, few studies their pharmacological treatment have been carried out. One suggested treatment approach is the use of different agents for different symptoms. In this article, we review the small number of published studies and case reports regarding this multi-pharmacological method of treatment for OC symptoms in schizophrenia. While each study used a somewhat different patient population and provided varying and limited information concerning patient sample, study design, and results, some tentative conclusions and treatment recommendations may be drawn from their findings.

Type
Feature Articles
Copyright
Copyright © Cambridge University Press 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Stengel, E. A study on some clinical aspects of the relationship between obsessional neurosis and psychotic reaction types. J Ment Science. 1945;91:166187.Google Scholar
2.Rosen, I. The clinical significance of obsessions in schizophrenia. J Ment Science. 1957;103:773788.Google Scholar
3.Fenton, WS, McGlashan, TH. The prognostic significance of obsessive-compulsive symptoms in schizophrenia. Am J Psychiatry. 1986;143:437441.Google Scholar
4.Berman, I, Kalinowski, A, Berman, SM, Lengua, J, Green, AL. Obsessive and compulsive symptoms in chronic schizophrenia. Compr Psychiatry. 1995;36:610.Google Scholar
5.Van Praag, HM, Asnis, GM, Kahn, RS, et al. Monoamines and abnormal behavior: a multi-aminergic perspective. Br J Psychiatry. 1990;157:723734.Google Scholar
6.Anonymous, Treatment of syndromes of symptoms in psychiatry. Lancet. 1988;2:373374. Editorial.Google Scholar
7.Yaryura-Tobias, JA, Neziroglu, MA, Bergman, L. Clomipramine for obsessive-compulsive neurosis: an organic approach. Curr Ther Res. 1976;20:541548.Google Scholar
8.Stroebel, CF, Szarek, BL, Glueck, BC. Use of clomipramine in treatment of obsessive compulsive symptomatology. J Clin Psychopharmacol. 1984;4:98100.Google Scholar
9.Zohar, J, Kaplan, Z, Benjamin, J. Clomipramine treatment of obsessive compulsive symptomatology in schizophrenic patients. J Clin Psychiatry. 1993;54:385388.Google Scholar
10.Bark, N, Lindenmayer, JP. Ineffectiveness of clomipramine for obsessive compulsive symptoms in a patient with schizophrenia. Am J Psychiatry. 1992;149:136137. Letter.Google Scholar
11.Zohar, J, Zohar-Kadouch, RC, Kindler, S. Current concepts in the pharmacological treatment of obsessive compulsive disorder. Drugs. 1992;43:210218.Google Scholar
12.Silver, H, Nassar, A. Fluvoxamine improves negative symptoms in treated chronic schizophrenia: an add-on, double-blind, placebo-controlled study. Biol Psych. 1992;31:698704.Google Scholar
13.Hwang, MY, Opler, LA. Schizophrenia with obsessive-compulsive features: assessment and treatment. Psychiatric Annals. 1994;24(9).Google Scholar
14.Lindenmayber, JP, Vakharia, M, Kanofsky, D. Fluoxetine in chronic schizophrenia. J Clin Psychopharm. 1990;1:76. Letter.CrossRefGoogle Scholar
15.Reznik, I, Sirota, P. Combined fluvoxamine and neuroleptic therapy for schizophrenic patients with obsessive compulsive disorder. Israel J Psychiatry. 1996;33:269270.Google Scholar
16.Baker, RW, Chengappa, KNR, Baird, JW, Steingard, S, Christ, MAG, Schooler, NR. Emergence of obsessive compulsive symptoms during treatment with clozapine. J Clin Psych. 1992;53:439441.Google Scholar
17.Patel, B, Tandon, R. Development of obsessive-compulsive symptoms during clozapine treatment. Am J Psychiatry. 1990;150:836. Letter.Google Scholar
18.Allen, L, Tejera, C. Treatment of clozapine-induced obsessive-compulsive symptoms with sertraline. Am J Psychiatry. 151:10961097. Letter.Google Scholar
19.Siris, SG, Bermanzohn, PC, Mason, SE, Shuwall, MA. Maintenance imipramine for secondary depression in schizophrenia: a controlled trial. Arch Gen Psychiatry. 1994;51:109115.CrossRefGoogle ScholarPubMed
20.Siris, SG, Morgan, V, Fagerstrom, R, Rifkin, A, Cooper, TB. Adjunctive imipramine in the treatment of post-psychotic depression in schizophrenia: a controlled trial. Arch Gen Psychiatry. 1987;44:533539.CrossRefGoogle Scholar
21.Kramer, MS, Vogel, WH, DiJohnson, C, et al. Antidepressants in “depressed” schizophrenic inpatients: a controlled trial. Arch Gen Psychiatry. 1989;46:922928.Google Scholar
22.Siris, SG. Adjunctive medications in the maintenance treatment of schizophrenia and their conceptual implications. Br J Psychiatry. 1993;163:6678.Google Scholar
23.Pulman, J, Yassa, R, Anath, J. Clomipramine treatment of repetitive behavior. Can J Psychiatry. 1984;29:254255.CrossRefGoogle ScholarPubMed