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Polygenic risk, family cohesion, and adolescent aggression in Mexican American and European American families: Developmental pathways to alcohol use

Published online by Cambridge University Press:  31 August 2018

Kit K. Elam ,
Laurie Chassin  and
Danielle Pandika
Kit K. Elam*
Affiliation:
Arizona State University
Laurie Chassin
Affiliation:
Arizona State University
Danielle Pandika
Affiliation:
Arizona State University
*
Address correspondence and reprint requests to: Kit K. Elam, Assistant Professor, T. Denny Sanford School for Social and Family Dynamics, Arizona State University, 951 S. Cady Mall, Tempe, AZ 85287; E-mail: kit.elam@asu.edu.
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Abstract

Poor family cohesion and elevated adolescent aggression are associated with greater alcohol use in adolescence and early adulthood. In addition, evocative gene–environment correlations (rGEs) can underlie the interplay between offspring characteristics and negative family functioning, contributing to substance use. Gene–environment interplay has rarely been examined in racial/ethnic minority populations. The current study examined adolescents’ polygenic risk scores for aggression in evocative rGEs underlying aggression and family cohesion during adolescence, their contributions to alcohol use in early adulthood (n = 479), and differences between Mexican American and European American subsamples. Results suggest an evocative rGE between polygenic risk scores, aggression, and low family cohesion, with aggression contributing to low family cohesion over time. Greater family cohesion was associated with lower levels of alcohol use in early adulthood and this association was stronger for Mexican American adolescents compared to European American adolescents. Results are discussed with respect to integration of culture and racial/ethnic minority samples into genetic research and implications for alcohol use.

Type
Special Issue Articles
Information
Development and Psychopathology , Volume 30 , Special Issue 5: Cultural Development and Psychopathology , December 2018 , pp. 1715 - 1728
Copyright
Copyright © Cambridge University Press 2018 

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Footnotes

This research was supported by National Institute of Alcohol Abuse and Alcoholism Grants AA016213 and AA022097 (to L.C.) and the National Institute on Drug Abuse and National Institutes of Health: Office of the Director, and Office of Behavioral and Social Sciences Research Grant K01DA042828 (to K.K.E).

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