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Profiles of diurnal cortisol and DHEA regulation among children: Associations with maltreatment experiences, symptomatology, and positive adaptation

Published online by Cambridge University Press:  30 May 2022

Elizabeth D. Handley Open the ORCID record for Elizabeth D. Handley [Opens in a new window] ,
Fred A. Rogosch ,
Erinn B. Duprey Open the ORCID record for Erinn B. Duprey [Opens in a new window] ,
Justin Russotti Open the ORCID record for Justin Russotti [Opens in a new window]  and
Dante Cicchetti
Elizabeth D. Handley*
Affiliation:
Mt. Hope Family Center, University of Rochester, Rochester, NY, USA
Fred A. Rogosch
Affiliation:
Mt. Hope Family Center, University of Rochester, Rochester, NY, USA
Erinn B. Duprey
Affiliation:
Mt. Hope Family Center, University of Rochester, Rochester, NY, USA Children’s Institute, Rochester, NY, USA
Justin Russotti
Affiliation:
Mt. Hope Family Center, University of Rochester, Rochester, NY, USA
Dante Cicchetti
Affiliation:
Mt. Hope Family Center, University of Rochester, Rochester, NY, USA Institute of Child Development, University of Minnesota, Minneapolis, MN, USA
*
Corresponding author: Elizabeth D. Handley, email: elizabeth_handley@urmc.rochester.edu
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Abstract

Person-centered methods represent an important advance in the simultaneous examination of multiple indicators of neuroendocrine functioning and may facilitate a more nuanced understanding of the impact of child maltreatment on hypothalamic–pituitary–adrenal axis dysregulation. The aims of the present study were threefold: (a) identify naturally occurring patterns of diurnal cortisol and dehydroepiandrosterone (DHEA) regulation among a sample of N = 1,258 children with and without histories of maltreatment, (b) investigate which neuroendocrine profiles characterize children with exposure to maltreatment, and (c) examine which profiles are related to adaptive outcomes and symptomatology among children. Cortisol and DHEA were sampled three times per day (9 a.m., 12 p.m., and 4 p.m.) across 5 and 2 days, respectively. Four profiles of cortisol and DHEA regulation were identified. Among females, a pattern marked by high cortisol and low DHEA was associated with more pervasive maltreatment experiences. Furthermore, we found evidence of adaptive interpersonal resilience such that children with maltreatment exposure who evidenced this pattern of high cortisol and low DHEA were viewed as more likeable than maltreated children with other neuroendocrine patterns. Finally, results pointed to higher levels of internalizing symptoms among children who displayed a profile marked by average cortisol and high DHEA.

Keywords

child maltreatmentneuroendocrinecortisolDHEAperson-centered
Type
Regular Article
Information
Development and Psychopathology , Volume 35 , Issue 4 , October 2023 , pp. 1614 - 1626
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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