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Fetal valproate syndrome and autism: additional evidence of an association

Published online by Cambridge University Press:  09 April 2001

Gail Williams
University of Louisville Child Evaluation Center, Louisville, KY, USA.
John King
Department of Pediatrics, Naval Medical Center, San Diego, CA, USA.
Michael Cunningham
Children's Craniofacial Center, Division of Genetics and Development, University of Washington, Seattle, USA.
Mark Stephan
Department of Pediatrics, Madigan Army Medical Center, Tacoma, WA, USA.
Bronwyn Kerr
Department of Genetics, Royal Manchester Children's Hospital, Pendlebury, Manchester, UK.
Joseph H Hersh
University of Louisville Child Evaluation Center, Louisville, KY, USA.
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Autism has been described in association with a variety of medical and genetic conditions. We previously reported on a patient whose clinical phenotype was compatible with both fetal valproate syndrome (FVS) and autism. Here we present five additional patients with FVS and autism. In all five of our patients, there was evidence of cognitive deficits, manifestations of autism, and typical phenotypic characteristics of FVS. The association between this known teratogen and autism has both clinical and research implications.

Case Report
© 2001 Mac Keith Press

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