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Fetal valproate syndrome and autism: additional evidence of an association

Published online by Cambridge University Press:  09 April 2001

Gail Williams
Affiliation:
University of Louisville Child Evaluation Center, Louisville, KY, USA.
John King
Affiliation:
Department of Pediatrics, Naval Medical Center, San Diego, CA, USA.
Michael Cunningham
Affiliation:
Children's Craniofacial Center, Division of Genetics and Development, University of Washington, Seattle, USA.
Mark Stephan
Affiliation:
Department of Pediatrics, Madigan Army Medical Center, Tacoma, WA, USA.
Bronwyn Kerr
Affiliation:
Department of Genetics, Royal Manchester Children's Hospital, Pendlebury, Manchester, UK.
Joseph H Hersh
Affiliation:
University of Louisville Child Evaluation Center, Louisville, KY, USA.
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Abstract

Autism has been described in association with a variety of medical and genetic conditions. We previously reported on a patient whose clinical phenotype was compatible with both fetal valproate syndrome (FVS) and autism. Here we present five additional patients with FVS and autism. In all five of our patients, there was evidence of cognitive deficits, manifestations of autism, and typical phenotypic characteristics of FVS. The association between this known teratogen and autism has both clinical and research implications.

Type
Case Report
Copyright
© 2001 Mac Keith Press

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