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ADHD: increased dopamine receptor availability linked to attention deficit and low neonatal cerebral blood flow

  • Hans C Lou (a1), Pedro Rosa (a1), Ole Pryds (a1), Hanne Karrebæk (a2), Jytte Lunding (a2), Paul Cumming (a1) and Albert Gjedde (a1)...
Abstract

Attention-deficit–hyperactivity disorder (ADHD), while largely thought to be a genetic disorder, has environmental factors that appear to contribute significantly to the aetiopathogenesis of the disorder. One such factor is pretern birth with vulnerable cerebrovascular homeostasis. We hypothesised that cerebral ischaemia at birth could contribute to persistent deficient dopaminergic neurotransmission, which is thought to be the pathophysiological basis of the disorder. We examined dopamine D2/3 receptor binding with positron emission tomography (PET) using [11C] raclopride as a tracer, and continuous reaction times (RT) with a computerized test of variables (TOVA) in six adolescents (12–14 years of age, one female) who had been examined with cerebral blood flow (CBF) measurements at preterm birth and had a subsequent history of attention deficit. We found that high dopamine receptor availability (‘empty receptors’) was linked with increased RT and RT variability, supporting the concept of a dopaminergic role in symptomatology. High dopamine receptor availability was predicted by low neonatal CBF, supporting the hypothesis of cerebral ischaemia as a contributing factor in infants susceptible to ADHD.

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Corresponding author
Centre of Functionally Integrative Neuroscience and PET Centre, Aarhus University Hospital, DK-8000 Aarhus, Denmark. E-mail: hclou@inet.uni2.dk
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Developmental Medicine and Child Neurology
  • ISSN: 0012-1622
  • EISSN: 1469-8749
  • URL: /core/journals/developmental-medicine-and-child-neurology
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