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XVI.—Strophanthus hispidus: its Natural History, Chemistry, and Pharmacology

Published online by Cambridge University Press:  17 January 2013

Thomas R. Fraser
Thomas R. Fraser
Affiliation:
Professor of Materia Medica in theUniversity of Edinburgh.
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Extract

In former papers on the pharmacological action of Strophanthus, dating from 1869, I selected for description, from the considerable number of experiments that had been made, merely those experiments which sufficed to illustrate the general features of the action, and especially such effects as seemed likely to form a basis for the application of Strophanthus to the treatment of disease.

I had intended to have followed, at no distant date, these preliminary and somewhat fragmentary notices by a more complete description of the pharmacological action, for which, indeed, nearly all the required experimental data had several years ago been obtained; but unavoidable circumstances prevented this intention from being fulfilled. In this part of the present paper the fuller description will be given; and if any excuse were required for doing so, it may perhaps be found in the circumstance that the anticipation of the therapeutic value of Strophanthus has been amply confirmed by the important position now occupied by it as a therapeutic agent.

Type
Research Article
Information
Earth and Environmental Science Transactions of The Royal Society of Edinburgh , Volume 36 , Issue 2 , 1892 , pp. 343 - 457
Copyright
Copyright © Royal Society of Edinburgh 1892

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References

page 344 note * Where it is not otherwise stated, the frog used in the experiments was the Rana temporaria. In only a few experiments R. esculenta was used.

page 345 note * Published in 1872 in a preliminary paper in Journal of Anatomy and Physiology, vol. vii. p. 142Google Scholar.

page 346 note * Published in 1872, Journal of Anatomy and Physiology, vol. vii. p. 147Google Scholar.

page 347 note * Published in 1872, Journal of Anatomy and Physiology, vol. vii. p. 146Google Scholar.

page 348 note * Trans. Roy. Soc. Edin., vol. xxxv. part iv., 1890Google Scholar.

page 352 note * Trans. Roy. Soc. Edin., vol. xxxv. part iv., 1890Google Scholar.

page 353 note * These data are derived from a research made by the author several years ago on the aconite alkaloids, but not yet published in detail.

page 364 note * During this experiment the temperature of the laboratory was nearly the same as during the immediately foregoing experiments.

page 381 note * Published in 1872 in Journal of Anatomy and Physiology, vol. vii. p. 152Google Scholar.

page 388 note * Published in Proc. Roy. Soc. Edin., vol. vii., 1869–1870, p. 101Google Scholar.

page 390 note * Published in 1872 in Journal of Anatomy and Physiology, vol. vii. p. 142Google Scholar.

page 390 note † Ibid., p. 145.

page 402 note * Archiv für Experimentelle Pathologie und Pharmalcologie, vol. xiii., 1881, p. 1Google Scholar.

page 403 note * This is when strophanthin is compared with Merck's purest digitalin. When experiments were made with the English digitalin, used in the experiments on blood-vessels (p. 420), strophanthin was found to act upon the heart three thousand times more powerfully than it.

page 456 note * In Experiments LXI., LXIII., and LXV. the speed of rotation of the drum was greater than in Experiments LXII., LXIV., and LXVI.