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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Cojutti, P. Maximova, N. Crichiutti, G. Isola, M. and Pea, F. 2015. Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation. Journal of Antimicrobial Chemotherapy, Vol. 70, Issue. 1, p. 198.

    Lyles, Rosie D. Trick, William E. Hayden, Mary K. Lolans, Karen Fogg, Louis Logan, Latania K. Shulman, Stanford T. Weinstein, Robert A. and Lin, Michael Y. 2015. Regional Epidemiology of Methicillin-ResistantStaphylococcus aureusAmong Critically Ill Children in a State With Mandated Active Surveillance. Journal of the Pediatric Infectious Diseases Society, p. piv050.


Changing epidemiology of methicillin-resistant Staphylococcus aureus colonization in paediatric intensive-care units

  • C. R. HERMOS (a1), T. J. SANDORA (a2) (a3), L. E. WILLIAMS (a2), N. MOSAMMAPARAST (a4) and A. J. McADAM (a2)
  • DOI:
  • Published online: 29 November 2012

Community-associated methicillin-resistant S. aureus (CA-MRSA) accounts for a growing proportion of hospital-onset infections, and colonization is a risk factor. This study aimed to determine changes in the prevalence of CA-MRSA colonization in paediatric intensive-care units (ICUs). A total of 495 paediatric patients colonized with MRSA from neonatal, medical, surgical, and cardiac ICUs between 2001 and 2009 were identified. Isolates were characterized by spa type, staphylococcal cassette chromosome (SCC) mec type and the presence of the genes encoding Panton–Valentine leukocidin (PVL). The proportion of patients colonized with MRSA remained stable (average 3·2%). The proportion of isolates with spa type 1, SCCmec type IV and PVL increased over time to maximums in 2009 of 36·1% (P < 0·001), 54·2% (P = 0·03) and 28·9% (P = 0·003), respectively. Antibiotic susceptibility patterns showed increasing proportions susceptible to clindamycin, gentamicin, tetracycline and trimethoprim-sulfamethoxazole (P values <0·001). In conclusion, the proportion of MRSA-colonized children in ICUs with CA-MRSA increased significantly over time.

Corresponding author
*Author for correspondence: Dr C. R. Hermos, 55 Lake Avenue North, Worcester, MA, USA. (Email:
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