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Invasive meningococcal disease in children in Jerusalem

  • C. STEIN-ZAMIR (a1), N. ABRAMSON (a1), G. ZENTNER (a1), H. SHOOB (a1), L. VALINSKY (a2) and C. BLOCK (a3)...
Abstract
SUMMARY

Neisseria meningitidis is an important cause of childhood meningitis and septicaemia. Between 1999 and 2005, 133 invasive meningococcal disease (IMD) cases occurred in Jerusalem, 112 (84·2%) of them in children aged 0–14 years. The annual incidence rate in Jerusalem was higher than the national average (2·45±0·6 vs. 1·13±0·16/100 000 population, P=0·002). Most of the children (82·1%) were from low socio-economic Arab and Jewish ultra-orthodox communities; mortality was higher among Arab than Jewish children (1·3 vs. 0·22/100 000 person-years, P=0·004). A cluster of 10 children with severe meningococcal sepsis (three fatalities) emerged in the winter of 2003–2004. Compared to the other 102 cases in 1999–2005 both meningococcaemia (100% vs. 51%, P=0·003) and mortality (30% vs. 6·9%, P=0·014) rates were higher. Serogroup B comprised 77·6% of the bacterial isolates. Pulsed-field gel electrophoresis showed considerable variability among cluster isolates, but significant resemblance in Arab cases throughout 1999–2005. The increased susceptibility of specific sub-populations to IMD necessitates further evaluation.

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Corresponding author
*Author for correspondence: Dr C. Stein-Zamir, Jerusalem District Health Office, 86 Jaffa Road, Jerusalem 94341, Israel. (Email: chen@lbjer.health.gov.il)
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1. CG Whitney , Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. New England Journal of Medicine 2003; 348: 17371746.

2. A Schuchat , for the Active Surveillance Team. Bacterial meningitis in the United States in 1995. New England Journal of Medicine 1997; 337: 970976.

3. AJ Pollard , ER Moxon . The meningococcus tamed? Archives of Disease in Childhood 2002; 87: 1317.

4. NE Rosenstein , The changing epidemiology of meningococcal disease in the United States, 1992–1996. Journal of Infectious Diseases 1999; 180: 18941901.

6. S Nadel , JS Kroll . Diagnosis and management of meningococcal disease: the need for centralized care. FEMS Microbiology Reviews 2007; 31: 7183.

7. NE Rosenstein , Meningococcal disease. New England Journal of Medicine 2001; 344: 13781388.

11. MN Tsolia , The evolving epidemiology of invasive meningococcal disease: a two-year prospective, population-based study in children in the area of Athens. FEMS Immunology and Medical Microbiology 2003; 36: 8794.

12. C Block , Forty years of meningococcal disease in Israel 1951–1990. Clinical Infectious Disease 1993; 17: 126132.

13. CJ Williams , Geographic correlation between deprivation and risk of meningococcal disease: an ecological study. BMC Public Health 2004; 4: 30.

16. I Pereiró , Risk factors for invasive disease among children in Spain. Journal of Infection 2004; 48: 320329.

17. S Deutch , Crowding as a risk factor of meningococcal disease in Danish preschool children: a nationwide population-based case-control study. Scandinavian Journal of Infectious Diseases 2004; 36: 2023.

23. CJ Hoebe , Space-time cluster analysis of invasive meningococcal disease. Emerging Infectious Diseases 2004; 10: 16211626.

24. JH Abramson . WINPEPI (PEPI-for-Windows): computer programs for epidemiologists. Epidemiologic Perspectives & Innovations 2004; 1: 6.

28. MJ Goldacre , SE Roberts , D Yeates . Case fatality rates for meningococcal disease in an English population, 1963–98: database study. British Medical Journal 2003; 327: 596597.

32. B Purcell , Effectiveness of antibiotics in preventing meningococcal disease after a case: systematic review. British Medical Journal 2004; 328: 1339.

35. SP Yazdankhah , BA Lindstedt , DA Caugant . Use of variable-number tandem repeats to examine genetic diversity of Neisseria meningitidis. Journal of Clinical Microbiology 2005; 43: 16991705.

37. J Holst , The concept of ‘tailor-made’, protein-based, outer membrane vesicle vaccines against meningococcal disease. Vaccine 2005; 23: 22022205.

38. J O'Hallahan , From secondary prevention to primary prevention: a unique strategy that gives hope to a country ravaged by meningococcal disease. Vaccine 2005; 23: 21972201.

41. MP Girard , A review of vaccine research and development: meningococcal disease. Vaccine 2006; 24: 46924700.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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