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Molluscum contagiosum: characterization of viral DNA and clinical features

  • C. D. Porter (a1), M. F. Muhlemann (a2), J. J. Cream (a2) and L. C. Archard (a1)
Abstract
SUMMARY

Restriction endonuclease analysis of molluscum contagiosum virus DNA revealed two subtypes. In a study of 46 isolates from 41 patients, some with no other disorder and some with atopic dermatitis, the ratio of MCV I isolates to MCV II was 34:12. Multiple clustered lesions removed at the same time from an individual patient yielded only one type of MCV. Lesions induced by MCV I or MCV II were indistinguishable on the basis of size and form. Neither subtype was associated exclusively with lesions at certain sites or with other clinical features. Heterogeneity of DNA restriction endonuclease cleavage patterns amongst isolates of the same subtype was observed, this being greatest for MCV II.

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S. T. Brown , J. F. Nalley S. J. Kraus (1981). Molluscum contagiosum. Sexually Transmitted Diseases 8, 227234.

S. M. J. Chaney , K. G. Warren , J. Kettyls , A. Zbitnue & J. H. Subak-Sharpe (1983). A comparative analysis of restriction enzyme digests of the DNA of herpes simplex virus isolated from genital and facial lesions. Journal of General Virology 64, 357371.

G. Darai , H. Reisner , J. Scholz , P. Schnitzler & H. Lordacher De Ruiz (1986). Analysis of the genome of molluscum contagiosum virus by restriction endonuclease analysis and molecular cloning. Journal of Medical Virology 18, 29–39.

C. D. Porter & L. C. Archard (1987). Characterisation and physical mapping of molluscum contagiosum virus DNA and location of a sequence capable of encoding a conserved domain of epidermal growth factor. Journal of General Virology 68, 673682.

R. Postlethwaite (1970). Molluscum contagiosum: a review. Archives of Environmental Health 21, 432452.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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