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Prevalence of hepatitis C virus infection in patients with COPD

  • D. R. SILVA (a1), J. STIFFT (a2), H. CHEINQUER (a2) and M. M. KNORST (a1)
Abstract
SUMMARY

Some studies have suggested that chronic hepatitis C virus (HCV) infection may induce an accelerated decline of forced expiratory volume in 1 second (FEV1). We performed a cross-sectional study to determine the prevalence of HCV infection in a sample of chronic obstructive pulmonary disease (COPD) patients and in a control group of blood donors. The clinical characteristics of HCV-positive and HCV-negative patients were compared. Anti-HCV antibody was determined and confirmed by HCV-RNA. The prevalence of HCV infection in COPD patients was 7·5% (95% CI 6·52–8·48) and in blood donors was 0·41% (95% CI 0·40–0·42). The HCV-positive patients had a lower FEV1 (34·7±8·6%) and a higher BODE index (median=6) than HCV-negative patients (42·7±16·5%, median=4, respectively) (P=0·011 and 0·027, respectively). Our results suggest a high prevalence of chronic HCV infection in patients with COPD in comparison with the blood donors. HCV-positive patients have a more severe disease.

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Corresponding author
*Author for correspondence: D. R. Silva, M.D., Rua Ramiro Barcelos, 2350, Bairro Santa Cecília, Porto Alegre, RS, Brazil. (Email: denise.rossato@terra.com.br)
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1.PJ Barnes . Chronic obstructive pulmonary disease. New England Journal of Medicine 2000; 343: 269278.

3.H Kanazawa , K Hirata , J Yoshikawa . Accelerated decline of lung function in COPD patients with chronic hepatitis C virus infection. Chest 2003; 123: 596599.

11.J Wanger , Standardisation of measurement of lung volumes. European Respiratory Journal 2005; 26: 511522.

12.N Macintyre , Standardisation of the single-breath determination of carbon monoxide uptake in the lung. European Respiratory Journal 2005; 26: 720735.

16.HL Tillman , MP Manns . Mode of hepatitis C virus infection, epidemiology, and chronicity rate in the general population and risk groups [Abstract]. Digestive Diseases Sciences 1996; 41: 2740.

17.CE Ramarakoto , Seroprevalence of hepatitis C and associated risk factors in urban areas of Antananarivo, Madagascar. BMC Infectious Diseases 2008; 8: 2531.

18.E Martínez-Bauer , Hospital admission is a relevant source of hepatitis C virus acquisition in Spain [Abstract]. Journal of Hepatology 2008; 48: 2027.

19.M Karmochkine , A case-control study of risk factors for hepatitis C infection in patients with unexplained routes of infection. Journal of Viral Hepatitis 2006; 13: 775782.

20.X Forns , Nosocomial transmission of HCV in the liver unit of a tertiary care center. Hepatology 2005; 41: 115122.

21.J Moormann , Hepatitis C virus and the lung – implications for therapy. Chest 2005; 128: 28822892.

23.PT Diaz , HIV infection increases susceptibility to smoking-induced emphysema. Chest 2000; 117: 285S.

25.M Saetta , CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 1998; 157: 822826.

26.LM Fabbri , Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 2003; 167: 418424.

27.JP Moormann , Induction of p38 and gCIqR-dependent IL-8 expression in pulmonary fibroblasts by soluble hepatitis C core protein. Respiratory Research 2005; 6: 105115.

30.C Mallette , MA Flynn , K Promrat . Outcome of screening for hepatitis C virus infection based on risk factors. American Journal of Gastroenterology 2008; 103: 131137.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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