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The emergence of enterovirus D68 in England in autumn 2014 and the necessity for reinforcing enterovirus respiratory screening

  • A. I. CARRION MARTIN (a1) (a2), R. G. PEBODY (a2), K. DANIS (a1) (a3), J. ELLIS (a2), S. NIAZI (a2), S. DE LUSIGNAN (a4) (a5), K. E. BROWN (a2), M. ZAMBON (a2) and D. J. ALLEN (a2) (a6)...
Summary
SUMMARY

In autumn 2014, enterovirus D68 (EV-D68) cases presenting with severe respiratory or neurological disease were described in countries worldwide. To describe the epidemiology and virological characteristics of EV-D68 in England, we collected clinical information on laboratory-confirmed EV-D68 cases detected in secondary care (hospitals), between September 2014 and January 2015. In primary care (general practitioners), respiratory swabs collected (September 2013–January 2015) from patients presenting with influenza-like illness were tested for EV-D68. In secondary care 55 EV-D68 cases were detected. Among those, 45 cases had clinical information available and 89% (40/45) presented with severe respiratory symptoms. Detection of EV-D68 among patients in primary care increased from 0.4% (4/1074; 95% CI 0.1–1.0) (September 2013–January 2014) to 0.8% (11/1359; 95% CI 0.4–1.5) (September 2014–January 2015). Characterization of EV-D68 strains circulating in England since 2012 and up to winter 2014/2015 indicated that those strains were genetically similar to those detected in 2014 in USA. We recommend reinforcing enterovirus surveillance through screening respiratory samples of suspected cases.

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Corresponding author
*Author for correspondence: A. I. Carrión Martín, National Infection Service, Public Health England, 61 Colindale Avenue, London, UK. (Email: Isidro.carrion@phe.gov.uk)
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Present address: Pathogen Molecular Biology Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.

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Epidemiology & Infection
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