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    Merckx, Joanna McCormack, Deirdre and Quach, Caroline 2016. Improving influenza vaccination in chronically ill children using a tertiary-care based vaccination clinic: Is there a role for the live-attenuated influenza vaccine (LAIV)?. Vaccine, Vol. 34, Issue. 6, p. 750.


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Estimated paediatric mortality associated with influenza virus infections, United States, 2003–2010

  • K. K. WONG (a1), P. CHENG (a2), I. FOPPA (a2), S. JAIN (a2), A. M. FRY (a2) and L. FINELLI (a2)
  • DOI: http://dx.doi.org/10.1017/S0950268814001198
  • Published online: 15 May 2014
Abstract
SUMMARY

Death certificate reports and laboratory-confirmed influenza deaths probably underestimate paediatric deaths attributable to influenza. Using US mortality data for persons aged <18 years who died during 28 September 2003 to 2 October 2010, we estimated influenza-attributable deaths using a generalized linear regression model based on seasonal covariates, influenza-certified deaths (deaths for which influenza was a reported cause of death), and occurrence during the 2009 pandemic period. Of 32 783 paediatric deaths in the death categories examined, 853 (3%) were influenza-certified. The estimated number of influenza-attributable deaths over the study period was 1·8 [95% confidence interval (CI) 1·3–2·8] times higher than the number of influenza-certified deaths. Influenza-attributable deaths were 2·1 (95% CI 1·5–3·4) times higher than influenza-certified deaths during the non-pandemic period and 1·1 (95% CI 1·0–1·8) times higher during the pandemic. Overall, US paediatric deaths attributable to influenza were almost twice the number reported by death certificate codes in the seasons prior to the 2009 pandemic.

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Corresponding author
*Author for correspondence: Dr K. K. Wong, 1600 Clifton Rd NE, MS E-03, Atlanta GA 30329, USA. (Email: vij4@cdc.gov)
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  • ISSN: 0950-2688
  • EISSN: 1469-4409
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